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Abstract:

As shown in single-sensillum recordings, iodobenzene has a bimodal effect on the receptor cell tuned to benzoic acid (BA) of the female silk moth Bombyx mor. Exposure to iodobenzene causes an inhibition of the response to BA. With stimulation by iodobenzene alone, a reduction of basic nerve impulse firing during exposure is followed by a transient post-stimulus excitation (rebound). We suggest that inhibition suppresses excitation during exposure but fades afterwards more rapidly than excitation. Due to the spatial equivalence of the iodine and the acid residue, these effects might indicate opposing interactions of iodobenzene with the specific site for the key compound BA. This is supported by the fact that substitutions by smaller halogens are less effective in both inhibition and rebound. The inhibitory effect but not the rebound with iodobenzene alone was also observed in receptor cells tuned to key compounds other than benzoic acid, e.g. in the cell most sensitive to 2,6-dimethyl-5-heptene-2-ol (DMH-cell) occurring in the same sensillum as the BA-cell, or in the bombykol- and bombykal-cells of the male. At least in these cells the inhibitory effect might reflect the action of iodobenzene on a general site, e.g. the lipid matrix of the plasma membrane of the receptor cells. © The Author 2005. Published by Oxford University Press. All rights reserved.

Registro:

Documento: Artículo
Título:Inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth Bombyx mori L
Autor:de Brito Sanchez, M.G.; Kaissling, K.-E.
Filiación:Laboratorio de Fisiología de Insectos, FCEyN, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Max-Planck-Institut für Verhaltensphysiologie, 82319 Seewiesen/Starnberg, Germany
Centre de Recherches sur la Cognition Animale - UMR 5169, Université Paul-Sabatier, CNRS, 118 route de Narbonne, 31062 Toulouse Cedex 04, France
Palabras clave:Aniline; Benzoic acid receptor cell; Bombyx mori; Inhibition; Iodobenzene; Olfactory receptor; benzoic acid; halide; halogen; iodine; iodobenzene; linalool; action potential; antenna; article; controlled study; inhibition kinetics; nerve cell stimulation; nerve conduction; nonhuman; olfactory receptor; priority journal; rebound; receptor binding; receptor potential; sensory system electrophysiology; silkworm; stimulus response; Bombyx; Bombyx mori
Año:2005
Volumen:30
Número:5
Página de inicio:435
Página de fin:442
DOI: http://dx.doi.org/10.1093/chemse/bji038
Título revista:Chemical Senses
Título revista abreviado:Chem. Senses
ISSN:0379864X
CODEN:CHSED
CAS:benzoic acid, 532-32-1, 582-25-2, 65-85-0, 766-76-7; iodine, 7553-56-2; iodobenzene, 591-50-4; linalool, 78-70-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0379864X_v30_n5_p435_deBritoSanchez

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Citas:

---------- APA ----------
de Brito Sanchez, M.G. & Kaissling, K.-E. (2005) . Inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth Bombyx mori L. Chemical Senses, 30(5), 435-442.
http://dx.doi.org/10.1093/chemse/bji038
---------- CHICAGO ----------
de Brito Sanchez, M.G., Kaissling, K.-E. "Inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth Bombyx mori L" . Chemical Senses 30, no. 5 (2005) : 435-442.
http://dx.doi.org/10.1093/chemse/bji038
---------- MLA ----------
de Brito Sanchez, M.G., Kaissling, K.-E. "Inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth Bombyx mori L" . Chemical Senses, vol. 30, no. 5, 2005, pp. 435-442.
http://dx.doi.org/10.1093/chemse/bji038
---------- VANCOUVER ----------
de Brito Sanchez, M.G., Kaissling, K.-E. Inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth Bombyx mori L. Chem. Senses. 2005;30(5):435-442.
http://dx.doi.org/10.1093/chemse/bji038