Artículo

Pomilio, A.B.; Vitale, A.A.; Ciprian-Ollivier, J.; Cetkovich-Bakmas, M.; Gómez, R.; Vázquez, G. "Ayahoasca: An experimental psychosis that mirrors the transmethylation hypothesis of schizophrenia" (1999) Journal of Ethnopharmacology. 65(1):29-51
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Abstract:

The experimental psychosis observed after drinking Ayahoasca, a South American hallucinogenic beverage from the Amazon Indians, reproduces the pathologic transmethylation theory of schizophrenia. This theory postulates a decrease in the monoamine oxidase (MAO) activity, which results in the accumulation of methylated indolealkylamines, such as bufotenin (5-hydroxy- N,N-dimethyltryptamine), N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N- dimethyltryptamine. These substances are strong hallucinogens as has been previously confirmed experimentally. On the other hand, it is known that Ayahoasca is a beverage usually prepared by boiling two plants, one of them rich in β-carbolines, which are naturally occurring strong inhibitors of MAO, and the other with high quantities of DMT. This particular combination reproduces what is supposed to occur under pathologic conditions of different psychoses. The effects of Ayahoasca were studied in subjects, assessing urine levels of DMT by gas chromatography-mass spectrometry (GC-MS) before and after the intake of the beverage. The results of this study confirm that the hallucinogenic compounds detected in the healthy subjects' (post-Hoasca, but not before) urine samples are the same as those found in samples from acute psychotic unmedicated patients. The chemical composition of the Ayahoasca beverage, and of the plant material used for its preparation are also reported as well as psychometric and neuroendocrine subject parameters.

Registro:

Documento: Artículo
Título:Ayahoasca: An experimental psychosis that mirrors the transmethylation hypothesis of schizophrenia
Autor:Pomilio, A.B.; Vitale, A.A.; Ciprian-Ollivier, J.; Cetkovich-Bakmas, M.; Gómez, R.; Vázquez, G.
Filiación:Prog. Plantas Toxicas Medicinales M., Depto. de Quim. Orgánica, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Departmento de Psiquiatría, Facultad de Ciencas Médicas, Universidad de Buenos Aires, Francisco de Vittoria 2324, 1425 Buenos Aires, Argentina
Palabras clave:Ayahoasca; Gas chromatography-mass spectrometry; MAO; Methylated indolalkylamines; Psychodisleptic; Schizophrenia; Transmethylation hypothesis; ayahoasca extract; ayurvedic drug; hydrocortisone; prolactin; psychedelic agent; serotonin; unclassified drug; article; botany; controlled study; drinking; drug accumulation; drug potency; enzyme activity; ethnopharmacology; extraction; gas chromatography; human; human experiment; hydrocortisone blood level; mass spectrometry; methylation; normal human; phytochemistry; phytotoxicity; prolactin blood level; psychometry; psychosis; schizophrenia; serotonin blood level; South America; tea; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Hydrocortisone; N,N-Dimethyltryptamine; Plant Extracts; Prolactin; Schizophrenia; Serotonin; South America
Año:1999
Volumen:65
Número:1
Página de inicio:29
Página de fin:51
DOI: http://dx.doi.org/10.1016/S0378-8741(98)00163-9
Título revista:Journal of Ethnopharmacology
Título revista abreviado:J. Ethnopharmacol.
ISSN:03788741
CODEN:JOETD
CAS:Hallucinogens; Hydrocortisone, 50-23-7; N,N-Dimethyltryptamine, 61-50-7; Plant Extracts; Prolactin, 9002-62-4; Serotonin, 50-67-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03788741_v65_n1_p29_Pomilio

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Citas:

---------- APA ----------
Pomilio, A.B., Vitale, A.A., Ciprian-Ollivier, J., Cetkovich-Bakmas, M., Gómez, R. & Vázquez, G. (1999) . Ayahoasca: An experimental psychosis that mirrors the transmethylation hypothesis of schizophrenia. Journal of Ethnopharmacology, 65(1), 29-51.
http://dx.doi.org/10.1016/S0378-8741(98)00163-9
---------- CHICAGO ----------
Pomilio, A.B., Vitale, A.A., Ciprian-Ollivier, J., Cetkovich-Bakmas, M., Gómez, R., Vázquez, G. "Ayahoasca: An experimental psychosis that mirrors the transmethylation hypothesis of schizophrenia" . Journal of Ethnopharmacology 65, no. 1 (1999) : 29-51.
http://dx.doi.org/10.1016/S0378-8741(98)00163-9
---------- MLA ----------
Pomilio, A.B., Vitale, A.A., Ciprian-Ollivier, J., Cetkovich-Bakmas, M., Gómez, R., Vázquez, G. "Ayahoasca: An experimental psychosis that mirrors the transmethylation hypothesis of schizophrenia" . Journal of Ethnopharmacology, vol. 65, no. 1, 1999, pp. 29-51.
http://dx.doi.org/10.1016/S0378-8741(98)00163-9
---------- VANCOUVER ----------
Pomilio, A.B., Vitale, A.A., Ciprian-Ollivier, J., Cetkovich-Bakmas, M., Gómez, R., Vázquez, G. Ayahoasca: An experimental psychosis that mirrors the transmethylation hypothesis of schizophrenia. J. Ethnopharmacol. 1999;65(1):29-51.
http://dx.doi.org/10.1016/S0378-8741(98)00163-9