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Abstract:

The effects of Cedrela lilloi and Trichilia elegans (Meliaceae) aqueous leaf extracts on several parameters of the mouse immune system were studied. Both extracts showed a strong anticomplementary activity and inhibited the phagocytosis of opsonized sheep erythrocytes and the activation of the oxidative metabolism by opsonized zymosan on peritoneal macrophages. The in vitro proliferation of spleen T-lymphocytes was also impaired. Furthermore, treatment of mice with the extracts diminished the delayed-type hypersensitivity response to sheep erythrocytes. These results suggest that both extracts exert a marked immunomodulatory effect on the mouse immune system.

Registro:

Documento: Artículo
Título:Immunomodulatory activities of Cedrela lilloi and Trichilia elegans aqueous leaf extracts
Autor:Nores, M.M.; Courrèges, M.C.; Benencia, F.; Coulombié, F.C.
Filiación:Laboratory of Virology, Faculty of Science, University of Buenos Aires, (1428) Buenos Aires, Argentina
Laboratorio de Virología, Dpto. Química Biologica, Fac. de Ciencias Exactas y Naturales, Pabellón II, (1428) Buenos Aires, Argentina
Palabras clave:Cedrela lilloi; Immune system; Immunomodulation; Leaf extracts; Mouse; Trichilia elegans; plant extract; zymosan; aerobic metabolism; animal cell; animal experiment; animal model; Argentina; article; complement inhibition; controlled study; delayed hypersensitivity; female; immunomodulation; lymphocyte culture; lymphocyte proliferation; medicinal plant; mouse; nonhuman; peritoneum macrophage; phagocytosis; plant leaf; sheep erythrocyte; spleen lymphocyte; subcutaneous drug administration; T lymphocyte; traditional medicine; Adjuvants, Immunologic; Animals; Argentina; Cell Separation; Complement Activation; Erythrocytes; Female; Hypersensitivity, Delayed; Lymphocyte Activation; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Nitroblue Tetrazolium; Phagocytosis; Plant Extracts; Plant Leaves; Sheep; T-Lymphocytes; Zymosan
Año:1997
Volumen:55
Número:2
Página de inicio:99
Página de fin:106
DOI: http://dx.doi.org/10.1016/S0378-8741(96)01480-8
Título revista:Journal of Ethnopharmacology
Título revista abreviado:J. ETHNOPHARMACOL.
ISSN:03788741
CODEN:JOETD
CAS:Adjuvants, Immunologic; Nitroblue Tetrazolium, 298-83-9; Plant Extracts; Zymosan, 9010-72-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03788741_v55_n2_p99_Nores

Referencias:

  • Andrei, G.M., Coulombié, F.C., Courrèges, M.C., De Torres, R.A., Coto, C.E., Meliacine, an antiviral compound from Melia azedarach L., inhibits interferon production (1990) Journal of Interferon Research, 10, pp. 469-475
  • Benencia, F., Courrèges, M.C., Massouh, E.J., Coulombié, F.C., Effect of Melia azedarach L. leaf extracts on human complement and polymorphonuclear leukocytes (1994) Journal of Ethnopharmacology, 41, pp. 53-57
  • Benencia, F., Courrèges, M.C., Nores, M.M., Coulombié, F.C., Immunomodulatory activities of Cedrela tubiflora leaf aqueous extracts (1995) Journal of Ethnopharmacology, 49, pp. 133-139
  • Benencia, F., Courrèges, M.C., Coulombié, F.C., In vitro activities of Cedrela tubiflora aqueous leaf extracts on murine macrophages, polymorphonuclear leukocytes and complement (1996) Phytotherapy Research, 10, pp. 37-41
  • Bhakuni, D.S., Dhar, M.L., Dhar, M.M., Dhawan, B.W., Mehratra, B.N., Screening of plants for biological activity. Part II (1969) Indian Journal of Experimental Biology, 7, pp. 250-262
  • Bray, D.H., Warhurst, D.C., Connolly, J.D., O'Neill, M.J., Phillipson, J.D., Plants as sources of antimalarial drugs. Part 7. Activity of some species of Meliaceae plants and their constituent limonoids (1990) Phytotherapy Research, 4, pp. 29-34
  • Coulombié, F.C., Andrei, G.M., Laguens, R.P., De Torres, R.A., Coto, C.E., Partially purified leaf extracts of Melia azedarach L. inhibit Tacaribe virus growth in neonatal mice (1992) Phytotherapy Research, 6, pp. 15-19
  • Courrèges, M.C., Benencia, F., Coto, C.E., Massouh, E.J., Coulombié, F.C., In vitro antiphagocytic effect of Melia azedarach leaf extracts on mouse peritoneal exudate cells (1994) Journal of Ethnopharmacology, 43, pp. 135-140
  • Fujiwara, T., Takeda, T., Ogihara, Y., Shimizu, M., Nomura, T., Tomita, T., Studies of the structure of polysaccharides from the bark of Melia azadirachta (1982) Chemical and Pharmaceutical Bulletin, 30, pp. 4025-4030
  • Klerx, J.P.A.M., Beukelman, C.J., Van Dijk, H., Willers, J.M.N., Microassay for colorimetric estimation of complement activity in guinea pig, human and mouse serum (1983) Journal of Immunological Methods, 63, pp. 215-220
  • Klerx, J.P.A.M., Van Dijk, H., Van Der Maaden, W.J., Willers, J.M.N., Analytic study of the differential anticomplementary effects of dextran sulphate and heparin in the assay for the mouse alternative pathway (1985) International Archives of Allergy Applied and Immunology, 78, pp. 182-189
  • Klerx, J.P.A.M., Van Oosterhout, A.J.M., Van Dijk, H., Nouwenberg, E.A., Willers, J.M.N., Anticomplementary amines are immunological adjuvants in mice (1985) Immunology Letters, 10, pp. 281-286
  • Labadie, R.P., Van Der Nat, J.M., Simons, J.M., Kroes, B.H., Kosasi, S., Van Der Berg, A.J.J., T'Hart, L.A., De Silva, K.T.D., An ethnopharmacognostic approach to the search of immunomodulators of plant origin (1989) Planta Medica, 55, pp. 339-348
  • Mayer, M.M., (1961) Experimental Immunochemistry, p. 133. , Kabat, E.A. and Mayer, M.M. (Eds.), Charles C. Thomas, Springfield, IL
  • Patel, N.G., Indians traditional medicine: Ayurveda (1986) Folk Medicine: The Art and Science, p. 57. , R.P. Steiner (Ed.), American Chemical Society, Washington, DC
  • Rademaker, P.M., Van Dijk, H., Willers, J.M.N., Involvement of membrane-associated sialic acid in the resistance of sheep erythrocytes to lysis by mouse complement (1981) Immunology Letters, 3, pp. 221-225
  • Toursarkissian, M., (1980) Plantas Medicinales de la Argentina, p. 86. , Hemisferio Sur (Ed.), Buenos Aires, Argentina
  • Van Der Nat, J.M., Klerx, J.P.A.M., Van Dijk, H., De Silva, K.T.D., Labadie, R.P., Immunomodulatory activity of an aqueous extract of Azadirachta indica stem bark (1987) Journal of Ethnopharmacology, 19, pp. 125-131
  • Van Dijk, H., Rademaker, P.M., Willers, J.M.N., Estimation of classical pathway of mouse complement activity by use of sensitized rabbit erythrocytes (1980) Journal of Immunological Methods, 39, pp. 257-268
  • Wilkinson, P.C., Neutrophil function test (1981) Techniques in Clinical Immunology, p. 273. , R.A. Thompson (Ed.), Blackwell Scientific, Oxford

Citas:

---------- APA ----------
Nores, M.M., Courrèges, M.C., Benencia, F. & Coulombié, F.C. (1997) . Immunomodulatory activities of Cedrela lilloi and Trichilia elegans aqueous leaf extracts. Journal of Ethnopharmacology, 55(2), 99-106.
http://dx.doi.org/10.1016/S0378-8741(96)01480-8
---------- CHICAGO ----------
Nores, M.M., Courrèges, M.C., Benencia, F., Coulombié, F.C. "Immunomodulatory activities of Cedrela lilloi and Trichilia elegans aqueous leaf extracts" . Journal of Ethnopharmacology 55, no. 2 (1997) : 99-106.
http://dx.doi.org/10.1016/S0378-8741(96)01480-8
---------- MLA ----------
Nores, M.M., Courrèges, M.C., Benencia, F., Coulombié, F.C. "Immunomodulatory activities of Cedrela lilloi and Trichilia elegans aqueous leaf extracts" . Journal of Ethnopharmacology, vol. 55, no. 2, 1997, pp. 99-106.
http://dx.doi.org/10.1016/S0378-8741(96)01480-8
---------- VANCOUVER ----------
Nores, M.M., Courrèges, M.C., Benencia, F., Coulombié, F.C. Immunomodulatory activities of Cedrela lilloi and Trichilia elegans aqueous leaf extracts. J. ETHNOPHARMACOL. 1997;55(2):99-106.
http://dx.doi.org/10.1016/S0378-8741(96)01480-8