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Abstract:

Chromatographic procedures (HPLC, GC-MS) are outlined in this paper for the analysis of alkaloids in poisonous Datura ferox seeds of Argentina, from which previously only quantitative analysis for scopolamine was known. Five additional tropane alkaloids are now identified as 3α-tigloyloxytropane (tigloyltropeine), 3-phenylacetoxy-6β,7β-epoxytropane (3-phenylacetoxyscopine), aposcopolamine (apohyoscine), 7β-hydroxy-6β-propenyloxy-3α-tropoyloxytropane, traces of 7β-hydroxy-6β-isovaleroyloxy-3α-tigloyloxytropane and a pyrrolidine alkaloid, hygrine. Two new structures, 3-phenylacetoxy-6β,7β-epoxytropane (3-phenylacetoxyscopine) and 7β-hydroxy-6β-propenyloxy-3α-tropoyloxytropane, are proposed on the basis of their spectra. Hyoscyamine, nicotine and tropane N-oxides were not detected in all samples studied. © 1995.

Registro:

Documento: Artículo
Título:Alkaloids of Datura ferox from Argentina
Autor:Vitale, A.A.; Acher, A.; Pomilio, A.B.
Filiación:PROPLAME-CONICET, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Pabellon 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:3-Phenylacetoxy-6β,7β-epoxytropane (3-phenylacetoxyscopine); 3α-Tigloyloxytropane (tigloyltropeine); 7β-Hydroxy-6β-isovaleroyloxy-3α-tigloyloxytropane; 7β-Hydroxy-6β-propenyloxy-3α-tropoyloxytropane; Aposcopolamine (apohyoscine); Datura ferox; GC-MS; HPLC; Hygrine; Scopolamine (hyoscine); Tropane alkaloids; hyoscyamine; nicotine; plant extract; scopolamine; tropane alkaloid; tropane derivative; argentina; article; drug determination; drug isolation; drug structure; drug toxicity; gas chromatography; high performance liquid chromatography; mass spectrometry; nonhuman; plant seed; Alkaloids; Argentina; Chromatography, High Pressure Liquid; Humans; Plant Extracts; Seeds
Año:1995
Volumen:49
Número:2
Página de inicio:81
Página de fin:89
DOI: http://dx.doi.org/10.1016/0378-8741(95)90035-7
Título revista:Journal of Ethnopharmacology
Título revista abreviado:J. Ethnopharmacol.
ISSN:03788741
CODEN:JOETD
CAS:hyoscyamine, 101-31-5, 306-03-6; nicotine, 54-11-5; scopolamine, 138-12-5, 51-34-3, 55-16-3; Alkaloids; Plant Extracts
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03788741_v49_n2_p81_Vitale

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Citas:

---------- APA ----------
Vitale, A.A., Acher, A. & Pomilio, A.B. (1995) . Alkaloids of Datura ferox from Argentina. Journal of Ethnopharmacology, 49(2), 81-89.
http://dx.doi.org/10.1016/0378-8741(95)90035-7
---------- CHICAGO ----------
Vitale, A.A., Acher, A., Pomilio, A.B. "Alkaloids of Datura ferox from Argentina" . Journal of Ethnopharmacology 49, no. 2 (1995) : 81-89.
http://dx.doi.org/10.1016/0378-8741(95)90035-7
---------- MLA ----------
Vitale, A.A., Acher, A., Pomilio, A.B. "Alkaloids of Datura ferox from Argentina" . Journal of Ethnopharmacology, vol. 49, no. 2, 1995, pp. 81-89.
http://dx.doi.org/10.1016/0378-8741(95)90035-7
---------- VANCOUVER ----------
Vitale, A.A., Acher, A., Pomilio, A.B. Alkaloids of Datura ferox from Argentina. J. Ethnopharmacol. 1995;49(2):81-89.
http://dx.doi.org/10.1016/0378-8741(95)90035-7