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Abstract:

The antimicrobial activity of extracts and constituents of Gomphrena martiana and Gomphrena boliviana (Amaranthaceae) were determined in order to identify the compounds responsible for the folk-medicinal use of these plants. Each extract was evaluated against 20 microorganisms, including Gram-positive and Gram-negative bacteria, spore-forming Gram-positive bacteria, an acid-fast bacterium, a fungus and two yeasts. Fractionation of each petroleum ether (PE) extract yielded five 5,6,7-trisubstituted flavones that were separately tested showing high activity against M. phlei (minimum inhibitory concentration (MIC) 15, 20 and 75 μg ml) approaching that of commercial bactericides. Other natural and synthetic flavonoids with diverse structures were also tested to define structure-activity relationships. Each EtOH extract was subsequently fractionated and monitored by bioassays leading to isorhamnetin 3-O-β-robinobioside (MIC 50 μg/ml) in both instances. This glycoside is reported here for the first time in G. boliviana. © 1992.

Registro:

Documento: Artículo
Título:Antimicrobial constituents of Gomphrena martiana and Gomphrena boliviana
Autor:Pomilio, A.B.; Buschi, C.A.; Tomes, C.N.; Viale, A.A.
Filiación:Departamento de Química Orgánica, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, 1428 Buenos AiresArgentina
Cátedra de Microbiología e Inmunología, Departamento de Química Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, 1428 Buenos AiresArgentina
Palabras clave:5,6,7-trisubstituted flavonoids; Antimicrobial constituents; Gomphrena boliviana; Gomphrena martiana; isorhamnetin 3-O-β-robinobioside; flavonoid; gomphrena boliviana extract; gomphrena martiana extract; isorhamnetin; isorhamnetin 3 robinobioside; plant extract; unclassified drug; antimicrobial activity; article; Aspergillus niger; Bacillus subtilis; bioassay; Candida albicans; chemical structure; Clostridium butyricum; Clostridium sporogenes; Clostridium tetani; Enterobacter aerogenes; Enterococcus faecalis; Escherichia coli; fungus; Gram negative bacterium; Gram positive bacterium; Klebsiella pneumoniae; Micrococcus luteus; Mycobacterium phlei; nonhuman; plant; priority journal; Proteus vulgaris; Pseudomonas aeruginosa; Saccharomyces cerevisiae; Salmonella; Serratia marcescens; Staphylococcus aureus; traditional medicine; yeast; Flavones; Fungi; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Plant Extracts; Plants, Medicinal; Support, Non-U.S. Gov't
Año:1992
Volumen:36
Número:2
Página de inicio:155
Página de fin:161
DOI: http://dx.doi.org/10.1016/0378-8741(92)90016-K
Título revista:Journal of Ethnopharmacology
Título revista abreviado:J. Ethnopharmacol.
ISSN:03788741
CODEN:JOETD
CAS:Flavones; Plant Extracts
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03788741_v36_n2_p155_Pomilio

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Citas:

---------- APA ----------
Pomilio, A.B., Buschi, C.A., Tomes, C.N. & Viale, A.A. (1992) . Antimicrobial constituents of Gomphrena martiana and Gomphrena boliviana. Journal of Ethnopharmacology, 36(2), 155-161.
http://dx.doi.org/10.1016/0378-8741(92)90016-K
---------- CHICAGO ----------
Pomilio, A.B., Buschi, C.A., Tomes, C.N., Viale, A.A. "Antimicrobial constituents of Gomphrena martiana and Gomphrena boliviana" . Journal of Ethnopharmacology 36, no. 2 (1992) : 155-161.
http://dx.doi.org/10.1016/0378-8741(92)90016-K
---------- MLA ----------
Pomilio, A.B., Buschi, C.A., Tomes, C.N., Viale, A.A. "Antimicrobial constituents of Gomphrena martiana and Gomphrena boliviana" . Journal of Ethnopharmacology, vol. 36, no. 2, 1992, pp. 155-161.
http://dx.doi.org/10.1016/0378-8741(92)90016-K
---------- VANCOUVER ----------
Pomilio, A.B., Buschi, C.A., Tomes, C.N., Viale, A.A. Antimicrobial constituents of Gomphrena martiana and Gomphrena boliviana. J. Ethnopharmacol. 1992;36(2):155-161.
http://dx.doi.org/10.1016/0378-8741(92)90016-K