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Abstract:

We examined membrane properties and synaptic responses of neurons in the mouse lateral superior olivary nucleus (LSO). Two clear populations were identified consistent with: principal neurons which are involved in detecting interaural intensity differences (IIDs) and efferent neurons of the lateral olivocochlear (LOC) system which project to the cochlea. Principal neurons fired a short latency action potential (AP) often followed by an AP train during maintained depolarization. They possessed sustained outward K + currents, with little or no transient K + current (I A) and a prominent hyperpolarization-activated non-specific cation conductance, I H. On depolarization, LOC neurons exhibited a characteristic delay to the first AP. These neurons possessed a prominent transient outward current I A, but had no I H. Both LOC and principal neurons received glutamatergic and glycinergic synaptic inputs. LOC synaptic responses decayed more slowly than those of principal neurons; the mean decay time constant of AMPA receptor-mediated EPSCs was around 1 ms in principal neurons and 4 ms in LOC neurons. Decay time constants for glycinergic IPSCs were around 5 ms in principal neurons and 10 ms in LOC neurons. We conclude that principal cells receive fast synaptic responses appropriate for integration of IID inputs, while the LOC cells possess excitatory and inhibitory receptors with much slower kinetics. © 2010 Elsevier B.V.

Registro:

Documento: Artículo
Título:Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons
Autor:Sterenborg, J.C.; Pilati, N.; Sheridan, C.J.; Uchitel, O.D.; Forsythe, I.D.; Barnes-Davies, M.
Filiación:Department of Cell Physiology and Pharmacology, University of Leicester, PO Box 138, Leicester, LE1 9HN, United Kingdom
Department of Medical and Social Care Education, University of Leicester, PO Box 138, Leicester, LE1 9HN, United Kingdom
MRC Toxicology Unit, University of Leicester, PO Box 138, Leicester, LE1 9HN, United Kingdom
Instituto de Fisiología y Biología Molecular y Neurociencias, Universidad de Buenos Aires-CONICET, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, C1428-Buenos Aires, Argentina
Palabras clave:4 aminobutyric acid receptor; AMPA receptor; glycine receptor; animal cell; animal tissue; article; cochlear nucleus; controlled study; depolarization; excitatory postsynaptic potential; hyperpolarization; inhibitory postsynaptic potential; latent period; lateral olivocochlear nucleus; lateral superior olivary nucleus; mouse; nerve potential; nonhuman; potassium current; priority journal; superior olivary nucleus; synaptic transmission; Animals; Auditory Pathways; Cochlear Nerve; Cyclic Nucleotide-Gated Cation Channels; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Inhibitory Postsynaptic Potentials; Kinetics; Mice; Mice, Inbred CBA; Neurons; Neurons, Efferent; Neurotransmitter Agents; Olivary Nucleus; Patch-Clamp Techniques; Potassium; Potassium Channels; Reaction Time
Año:2010
Volumen:270
Número:1-2
Página de inicio:119
Página de fin:126
DOI: http://dx.doi.org/10.1016/j.heares.2010.08.013
Título revista:Hearing Research
Título revista abreviado:Hear. Res.
ISSN:03785955
CODEN:HERED
CAS:Cyclic Nucleotide-Gated Cation Channels; Glutamic Acid, 56-86-0; Glycine, 56-40-6; Neurotransmitter Agents; Potassium, 7440-09-7; Potassium Channels; hyperpolarization-activated cation channel
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03785955_v270_n1-2_p119_Sterenborg

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Citas:

---------- APA ----------
Sterenborg, J.C., Pilati, N., Sheridan, C.J., Uchitel, O.D., Forsythe, I.D. & Barnes-Davies, M. (2010) . Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons. Hearing Research, 270(1-2), 119-126.
http://dx.doi.org/10.1016/j.heares.2010.08.013
---------- CHICAGO ----------
Sterenborg, J.C., Pilati, N., Sheridan, C.J., Uchitel, O.D., Forsythe, I.D., Barnes-Davies, M. "Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons" . Hearing Research 270, no. 1-2 (2010) : 119-126.
http://dx.doi.org/10.1016/j.heares.2010.08.013
---------- MLA ----------
Sterenborg, J.C., Pilati, N., Sheridan, C.J., Uchitel, O.D., Forsythe, I.D., Barnes-Davies, M. "Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons" . Hearing Research, vol. 270, no. 1-2, 2010, pp. 119-126.
http://dx.doi.org/10.1016/j.heares.2010.08.013
---------- VANCOUVER ----------
Sterenborg, J.C., Pilati, N., Sheridan, C.J., Uchitel, O.D., Forsythe, I.D., Barnes-Davies, M. Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons. Hear. Res. 2010;270(1-2):119-126.
http://dx.doi.org/10.1016/j.heares.2010.08.013