Artículo

De'Nobili, M.D.; Curto, L.M.; Delfino, J.M.; Soria, M.; Fissore, E.N.; Rojas, A.M. "Performance of alginate films for retention of l-(+)-ascorbic acid" (2013) International Journal of Pharmaceutics. 450(1-2):95-103
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Abstract:

In view of acting as controlled delivery systems for nutritional supplementation, therapy or antioxidant activity at interfaces, alginate films of different copolymer composition and glycerol plasticizer levels were developed in the presence of Ca2+ for achieving higher stability of l-(+)-ascorbic acid (AA). The ability of the alginate network to preserve AA from hydrolysis, tested by storage under vacuum at 25 C, only decreased with the relative humidity (RH) increase when alginates were mainly constituted by guluronic-guluronic acid blocks (GG), whereas also decreased with the glycerol level increase when mannuronic-mannuronic acid (MM) and/or alternating guluronic-mannuronic (GM + MG) flexible blocks were present in higher proportions. This result could be probably related to the lower capability of the latter alginate block compositions to immobilize water in the network as they are not able to constitute Ca2+ mediated junction zones where water molecules are highly retained. Films also studied under air storage showed that even at less favorable conditions of RH and glycerol levels, both GG and GM + MG enriched alginate networks in general preserved AA from oxidation. It also demonstrated that hydrolysis is the principal way by which AA is lost when supported in films. © 2013 Elsevier B.V.

Registro:

Documento: Artículo
Título:Performance of alginate films for retention of l-(+)-ascorbic acid
Autor:De'Nobili, M.D.; Curto, L.M.; Delfino, J.M.; Soria, M.; Fissore, E.N.; Rojas, A.M.
Filiación:Departamento de Industrias, Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, 1428 Buenos Aires, Argentina
Department of Biological Chemistry, Institute of Biochemistry and Biophysics - IQUIFIB (CONICET), University of Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina
Microbiologia Agricola, Instituto de Investigaciones en Biociencias Agricolas y Ambientales - INBA, Facultad de Agronomía, University of Buenos Aires, Av. San Martin 4453, 1417 Buenos Aires, Argentina
Palabras clave:Alginate films; Antioxidant interface; Ascorbic acid hydrolysis; Biomolecule delivery; Glycerol; alginic acid; ascorbic acid; calcium alginate; glycerol; mannuronic acid; water; article; drug hydrolysis; drug stability; humidity; molecule; priority journal; temperature; Alginates; Ascorbic Acid; Drug Stability; Drug Storage; Glycerol; Humidity; Hydrolysis; Oxidation-Reduction; Plasticizers
Año:2013
Volumen:450
Número:1-2
Página de inicio:95
Página de fin:103
DOI: http://dx.doi.org/10.1016/j.ijpharm.2013.04.027
Título revista:International Journal of Pharmaceutics
Título revista abreviado:Int. J. Pharm.
ISSN:03785173
CODEN:IJPHD
CAS:alginic acid, 28961-37-7, 29894-36-8, 9005-32-7, 9005-38-3; ascorbic acid, 134-03-2, 15421-15-5, 50-81-7; calcium alginate, 9005-35-0; glycerol, 56-81-5; water, 7732-18-5; Alginates; Ascorbic Acid, PQ6CK8PD0R; Glycerol, PDC6A3C0OX; Plasticizers
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03785173_v450_n1-2_p95_DeNobili

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Citas:

---------- APA ----------
De'Nobili, M.D., Curto, L.M., Delfino, J.M., Soria, M., Fissore, E.N. & Rojas, A.M. (2013) . Performance of alginate films for retention of l-(+)-ascorbic acid. International Journal of Pharmaceutics, 450(1-2), 95-103.
http://dx.doi.org/10.1016/j.ijpharm.2013.04.027
---------- CHICAGO ----------
De'Nobili, M.D., Curto, L.M., Delfino, J.M., Soria, M., Fissore, E.N., Rojas, A.M. "Performance of alginate films for retention of l-(+)-ascorbic acid" . International Journal of Pharmaceutics 450, no. 1-2 (2013) : 95-103.
http://dx.doi.org/10.1016/j.ijpharm.2013.04.027
---------- MLA ----------
De'Nobili, M.D., Curto, L.M., Delfino, J.M., Soria, M., Fissore, E.N., Rojas, A.M. "Performance of alginate films for retention of l-(+)-ascorbic acid" . International Journal of Pharmaceutics, vol. 450, no. 1-2, 2013, pp. 95-103.
http://dx.doi.org/10.1016/j.ijpharm.2013.04.027
---------- VANCOUVER ----------
De'Nobili, M.D., Curto, L.M., Delfino, J.M., Soria, M., Fissore, E.N., Rojas, A.M. Performance of alginate films for retention of l-(+)-ascorbic acid. Int. J. Pharm. 2013;450(1-2):95-103.
http://dx.doi.org/10.1016/j.ijpharm.2013.04.027