Abstract:
The effects of addition of divalent cations and phosphate buffer on the degree of β-carotene encapsulation in a mannitol matrix during freeze-drying were analyzed. The degradation rate of encapsulated β-carotene as a function of % RH and its relationship with the physical state of the matrix during storage at 25 °C was also studied. The presence of phosphate salts significantly delayed mannitol crystallization at a highly satisfactory degree during freeze-drying and, consequently, the degree of β-carotene encapsulation increased. This effect was maintained over quite long time during storage of the freeze-dried samples at 25 °C. Unavoidable local variations in water content during 3 years storage caused the decrease of Tg values and made the crystallization degree to increase. The divalent cations showed a synergistic effect and also modified the kinetics of β-carotene degradation during storage, increasing its stability. The mechanism of crystallization inhibition likely includes a change in hydrogen bond network or/and change in molecular mobility in the presence of divalent cations and phosphate anions. The degradation rate of β-carotene in a mannitol/KH2PO4 matrix increased as increasing % RH until a value at which the samples collapsed (75% RH), and then the degradation rate decreased. Collapse phenomena may affect diffusion of oxygen from the surface to the inside of the matrix and increase retention of β-carotene. Surface color was not an appropriate indicator for β-carotene degradation, because it was mostly dependent on the optical properties of the matrix, which changed with the degree of matrix hydration and collapse. © 2006 Elsevier B.V. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | β-Carotene encapsulation in a mannitol matrix as affected by divalent cations and phosphate anion |
Autor: | Sutter, S.C.; Buera, M.P.; Elizalde, B.E. |
Filiación: | Departamento de Industrias, Facultad Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Ciudad Universitaria, Buenos Aires, Argentina
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Palabras clave: | β-Carotene; Amorphous-state; Crystallization inhibitor; Encapsulation; Mannitol crystallization; Storage stability; beta carotene; buffer; divalent cation; mannitol; phosphate; article; color; crystallization; differential scanning calorimetry; drug degradation; drug stability; encapsulation; freeze drying; glass transition temperature; hydration; hydrogen bond; priority journal; storage temperature; surface property; water content; Anions; beta Carotene; Buffers; Cations, Divalent; Chemistry, Pharmaceutical; Color; Crystallization; Drug Compounding; Drug Stability; Drug Storage; Excipients; Freeze Drying; Glycine; Humidity; Kinetics; Mannitol; Models, Chemical; Phosphates; Potassium Compounds; Surface Properties; Technology, Pharmaceutical; Vitamins; Water |
Año: | 2007
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Volumen: | 332
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Número: | 1-2
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Página de inicio: | 45
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Página de fin: | 54
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DOI: |
http://dx.doi.org/10.1016/j.ijpharm.2006.09.023 |
Título revista: | International Journal of Pharmaceutics
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Título revista abreviado: | Int. J. Pharm.
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ISSN: | 03785173
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CODEN: | IJPHD
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CAS: | beta carotene, 7235-40-7; mannitol, 69-65-8, 87-78-5; phosphate, 14066-19-4, 14265-44-2; Anions; beta Carotene, 7235-40-7; Buffers; Cations, Divalent; Excipients; Glycine, 56-40-6; Mannitol, 69-65-8; Phosphates; Potassium Compounds; potassium phosphate, 16068-46-5; Vitamins; Water, 7732-18-5
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03785173_v332_n1-2_p45_Sutter |
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Citas:
---------- APA ----------
Sutter, S.C., Buera, M.P. & Elizalde, B.E.
(2007)
. β-Carotene encapsulation in a mannitol matrix as affected by divalent cations and phosphate anion. International Journal of Pharmaceutics, 332(1-2), 45-54.
http://dx.doi.org/10.1016/j.ijpharm.2006.09.023---------- CHICAGO ----------
Sutter, S.C., Buera, M.P., Elizalde, B.E.
"β-Carotene encapsulation in a mannitol matrix as affected by divalent cations and phosphate anion"
. International Journal of Pharmaceutics 332, no. 1-2
(2007) : 45-54.
http://dx.doi.org/10.1016/j.ijpharm.2006.09.023---------- MLA ----------
Sutter, S.C., Buera, M.P., Elizalde, B.E.
"β-Carotene encapsulation in a mannitol matrix as affected by divalent cations and phosphate anion"
. International Journal of Pharmaceutics, vol. 332, no. 1-2, 2007, pp. 45-54.
http://dx.doi.org/10.1016/j.ijpharm.2006.09.023---------- VANCOUVER ----------
Sutter, S.C., Buera, M.P., Elizalde, B.E. β-Carotene encapsulation in a mannitol matrix as affected by divalent cations and phosphate anion. Int. J. Pharm. 2007;332(1-2):45-54.
http://dx.doi.org/10.1016/j.ijpharm.2006.09.023