Artículo
Bontempi, E.; Cazzulo, J.J. "Digestion of human immunoglobulin G by the major cysteine proteinase (cruzipain) from Trypanosoma cruzi" (1990) FEMS Microbiology Letters. 70(3):337-341
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Abstract:
The major cysteine proteinase (cruzipain) from Trypanosoma cruzi was able to digest human IgG, as shown by polyacrylamide gel electrophoresis in the presence of SDS, and by gel filtration on a Superose 12 column, in a FPLC system. The Fab fragment of IgG was only slightly degraded, but Fc was extensively hydrolyzed to small peptides. The results suggest that cruzipain might be involved in the defense mechanisms of the parasite against the immune response of the host. © 1990 Federation of European Microbiological Societies.
Registro:
| Documento: | Artículo |
| Título: | Digestion of human immunoglobulin G by the major cysteine proteinase (cruzipain) from Trypanosoma cruzi |
| Autor: | Bontempi, E.; Cazzulo, J.J. |
| Filiación: | Instituto Nacional de Diagnóstico e Investigación de la Enfermedad de Chagas Dr. Mario Fatala Chaben, Misterio de Salud y Acción Social, Buenos Aires, Argentina Instituto de Investigaciones Bioquimicas Luis F. Leloir, Fundación Campomar - Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina |
| Palabras clave: | Crazipain; Cysteine proteinase; Fc degradation; IgG degradation; Trypanosoma cruzi; proteinase; cruzipain; cysteine proteinase; immunoglobulin F(ab) fragment; immunoglobulin Fc fragment; immunoglobulin G; article; human; human cell; nonhuman; priority journal; protozoon; trypanosoma cruzi; animal; enzymology; hydrolysis; Trypanosoma cruzi; Protozoa; Trypanosoma; Trypanosoma cruzi; Animal; Cysteine Endopeptidases; Human; Hydrolysis; Immunoglobulin G; Immunoglobulins, Fab; Immunoglobulins, Fc; Support, Non-U.S. Gov't; Trypanosoma cruzi |
| Año: | 1990 |
| Volumen: | 70 |
| Número: | 3 |
| Página de inicio: | 337 |
| Página de fin: | 341 |
| DOI: | http://dx.doi.org/10.1016/S0378-1097(05)80019-9 |
| Título revista: | FEMS Microbiology Letters |
| Título revista abreviado: | FEMS Microbiol. Lett. |
| ISSN: | 03781097 |
| CODEN: | FMLED |
| CAS: | cysteine proteinase, 37353-41-6; immunoglobulin G, 97794-27-9; cruzipain, EC 3.4.22.-; Cysteine Endopeptidases, EC 3.4.22; Immunoglobulin G; Immunoglobulins, Fab; Immunoglobulins, Fc |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03781097_v70_n3_p337_Bontempi |
Referencias:
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Citas:
---------- APA ----------
Bontempi, E. & Cazzulo, J.J. (1990) . Digestion of human immunoglobulin G by the major cysteine proteinase (cruzipain) from Trypanosoma cruzi. FEMS Microbiology Letters, 70(3), 337-341.http://dx.doi.org/10.1016/S0378-1097(05)80019-9
---------- CHICAGO ----------
Bontempi, E., Cazzulo, J.J. "Digestion of human immunoglobulin G by the major cysteine proteinase (cruzipain) from Trypanosoma cruzi" . FEMS Microbiology Letters 70, no. 3 (1990) : 337-341.http://dx.doi.org/10.1016/S0378-1097(05)80019-9
---------- MLA ----------
Bontempi, E., Cazzulo, J.J. "Digestion of human immunoglobulin G by the major cysteine proteinase (cruzipain) from Trypanosoma cruzi" . FEMS Microbiology Letters, vol. 70, no. 3, 1990, pp. 337-341.http://dx.doi.org/10.1016/S0378-1097(05)80019-9
---------- VANCOUVER ----------
Bontempi, E., Cazzulo, J.J. Digestion of human immunoglobulin G by the major cysteine proteinase (cruzipain) from Trypanosoma cruzi. FEMS Microbiol. Lett. 1990;70(3):337-341.http://dx.doi.org/10.1016/S0378-1097(05)80019-9
