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Abstract:

The effects of specific inhibitors of glycoprotein trimming reactions on Junin virus (JV) replication were investigated. Bromoconduritol, an inhibitor of glucosidase II, significantly reduced infective virus production (DE50: 1.1 mM) and viral protein expression. Neither 1-deoxynojirimycin, an inhibitor of both glucosidases I and II, nor 1-deoxymannojirimycin and swainsonine, inhibitors of mannosidase I and II, respectively, showed any activity against JV multiplication. These results are the first evidence that the acquisition of a complex form of the envelope glycoprotein oligosaccharide chains is not essential for JV infectivity. The effect of bromoconduritol was reversible and probably due to the formation of an unstable intermediate oligosaccharide structure which may be more sensitive to degradative proteolysis. © 1993.

Registro:

Documento: Artículo
Título:The effects of oligosaccharide trimming inhibitors on glycoprotein expression and infectivity of Junin virus
Autor:Silber, A.M.; Candurra, N.A.; Elsa B., D.
Filiación:Laboratorio de Virología, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
Palabras clave:Glycoprotein expression; Glycoprotein processing; Junin virus; Oligosaccharide trimming inhibitors; Virus infectively; 1 deoxymannonojirimycin; 1 deoxynojirimycin; bromoconduritol; enzyme inhibitor; glycoprotein; glycosidase inhibitor; oligosaccharide; swainsonine; animal cell; article; cell culture; etiology; glycoprotein synthesis; junin virus; monkey; nonhuman; priority journal; protein processing; virus infectivity; virus replication; 1-Deoxynojirimycin; alpha-Glucosidases; Animal; Arenaviruses, New World; Fluorescent Antibody Technique; Glycoproteins; Inositol; Oligosaccharides; Support, Non-U.S. Gov't; Swainsonine; Vero Cells; Viral Proteins; Virus Replication; Animalia; Junin virus
Año:1993
Volumen:109
Número:1
Página de inicio:39
Página de fin:43
DOI: http://dx.doi.org/10.1111/j.1574-6968.1993.tb06140.x
Título revista:FEMS Microbiology Letters
Título revista abreviado:FEMS Microbiol. Lett.
ISSN:03781097
CODEN:FMLED
CAS:1-Deoxynojirimycin, 19130-96-2; 4-nitrophenyl-alpha-glucosidase, EC 3.2.1.-; 6-bromoconduritol, 42014-74-4; alpha-Glucosidases, EC 3.2.1.20; Glycoproteins; Inositol, 6917-35-7; Oligosaccharides; Swainsonine, 72741-87-8; Viral Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03781097_v109_n1_p39_Silber

Referencias:

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Citas:

---------- APA ----------
Silber, A.M., Candurra, N.A. & Elsa B., D. (1993) . The effects of oligosaccharide trimming inhibitors on glycoprotein expression and infectivity of Junin virus. FEMS Microbiology Letters, 109(1), 39-43.
http://dx.doi.org/10.1111/j.1574-6968.1993.tb06140.x
---------- CHICAGO ----------
Silber, A.M., Candurra, N.A., Elsa B., D. "The effects of oligosaccharide trimming inhibitors on glycoprotein expression and infectivity of Junin virus" . FEMS Microbiology Letters 109, no. 1 (1993) : 39-43.
http://dx.doi.org/10.1111/j.1574-6968.1993.tb06140.x
---------- MLA ----------
Silber, A.M., Candurra, N.A., Elsa B., D. "The effects of oligosaccharide trimming inhibitors on glycoprotein expression and infectivity of Junin virus" . FEMS Microbiology Letters, vol. 109, no. 1, 1993, pp. 39-43.
http://dx.doi.org/10.1111/j.1574-6968.1993.tb06140.x
---------- VANCOUVER ----------
Silber, A.M., Candurra, N.A., Elsa B., D. The effects of oligosaccharide trimming inhibitors on glycoprotein expression and infectivity of Junin virus. FEMS Microbiol. Lett. 1993;109(1):39-43.
http://dx.doi.org/10.1111/j.1574-6968.1993.tb06140.x