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Abstract:

The aim of the present study was to evaluate the effect of aluminum (A1) on in vivo erythropoiesis in mice that had received short- and long-term A1 overloading. At the end of each treatment period, clonal assays of-late erythroid progenitor cells (CFU-E) stimulated in vitro with erythropoietin were carried out, hematological parameters determined, and histological aluminon staining performed on bone and liver. After 2 weeks of-oral ingestion of either A1 chloride or A1 citrate (10 pmol per day), poor CFU-E growth was obtained but no differences in hematocrit (Ht) and hemoglobin (Hb) values were found when comparing the treated and control groups. CFU-E development, determined after loading mice with A1 citrate during 22 weeks (10 μmol/day), proved to be heavily depressed, and significant reductions in Ht, Hb concentration and erythrocyte osmotic fragility were also observed. No A1 accumulation could be demonstrated in tissue, using histological aluminon staining. The results suggest that, even in the absence of signs of anemia, ingested A1 may depress hematopoiesis by affecting red blood cell production and cell destruction.

Registro:

Documento: Artículo
Título:Depressed erythroid progenitor cell activity in aluminum-overloaded mice
Autor:Garbossa, G.; Gutnisky, A.; Nesse, A.
Filiación:Depto. de Quim. Biológica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Ctro. Estud. Farmacologicos B., Buenos Aires, Argentina
Depto. de Quim. Biológica, Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria (1428), Pabellón II, Buenos Aires, Argentina
Palabras clave:Aluminum; Aluminum toxicity; Anemia; CFU-E; Erythroid colony-forming units; Erythropoiesis; Median osmotic fragility; Osmotic fragility curves; aluminum; endogenous compound; erythropoietin; hemoglobin; animal cell; animal model; article; bone; controlled study; erythroid precursor cell; erythropoiesis; hematocrit; histology; liver; mouse; nonhuman; priority journal; Aluminum; Aluminum Compounds; Animals; Bone and Bones; Cell Division; Chlorides; Citric Acid; Erythroid Progenitor Cells; Erythropoiesis; Erythropoietin; Hematocrit; Hemoglobins; Liver; Mice; Mice, Inbred C3H; Osmotic Fragility
Año:1996
Volumen:22
Número:4
Página de inicio:214
Página de fin:218
Título revista:Mineral and Electrolyte Metabolism
Título revista abreviado:MINER. ELECTROLYTE METABOL.
ISSN:03780392
CODEN:MELMD
CAS:aluminum chloride, 7446-70-0; Aluminum Compounds; Aluminum, 7429-90-5; Chlorides; Citric Acid, 77-92-9; Erythropoietin, 11096-26-7; Hemoglobins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03780392_v22_n4_p214_Garbossa

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Citas:

---------- APA ----------
Garbossa, G., Gutnisky, A. & Nesse, A. (1996) . Depressed erythroid progenitor cell activity in aluminum-overloaded mice. Mineral and Electrolyte Metabolism, 22(4), 214-218.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03780392_v22_n4_p214_Garbossa [ ]
---------- CHICAGO ----------
Garbossa, G., Gutnisky, A., Nesse, A. "Depressed erythroid progenitor cell activity in aluminum-overloaded mice" . Mineral and Electrolyte Metabolism 22, no. 4 (1996) : 214-218.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03780392_v22_n4_p214_Garbossa [ ]
---------- MLA ----------
Garbossa, G., Gutnisky, A., Nesse, A. "Depressed erythroid progenitor cell activity in aluminum-overloaded mice" . Mineral and Electrolyte Metabolism, vol. 22, no. 4, 1996, pp. 214-218.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03780392_v22_n4_p214_Garbossa [ ]
---------- VANCOUVER ----------
Garbossa, G., Gutnisky, A., Nesse, A. Depressed erythroid progenitor cell activity in aluminum-overloaded mice. MINER. ELECTROLYTE METABOL. 1996;22(4):214-218.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03780392_v22_n4_p214_Garbossa [ ]