Artículo
Abstract:
Aluminum (Al) has been associated with anemia in chronic renal failure patients under hemodialysis as well as in Al-overloaded animals. In an attempt to elucidate further the mechanism of Al toxicity we have investigated the effect of this ion on erythropoiesis in vitro. Mouse bone marrow cells were stimulated in vitro with erythropoietin (Epo) in the presence of Al3+ ion and erythroid colony-forming units were then determined. Results of this study indicate that Al compounds (chloride and citrate) at concentrations as low as 0.37 μmol Al/l inhibit erythropoiesis in vitro through a mechanism dependent upon the availability of transferrin to bind to aluminum. This process cannot be reversed by increasing Epo doses. This inhibition only occurs in the presence of Epo at early stages during the interaction of the hormone with its target cell.
Registro:
| Documento: | Artículo |
| Título: | The inhibitory action of aluminum on mouse bone marrow cell growth: Evidence for an erythropoietin- and transferrin-mediated mechanism |
| Autor: | Garbossa, G.; Gutnisky, A.; Nesse, A. |
| Filiación: | Dept. de Quimica Biologica, Fac. de Ciencias Exactas/Naturales, Ciudad Universitaria, 1428 Buenos Aires, Argentina |
| Palabras clave: | aluminum; aluminum toxicity; anemia; erythroid colony-forming units; erythropoiesis; aluminum; erythropoietin; transferrin; animal cell; article; bone marrow; cell culture; cell growth; cell metabolism; erythropoiesis; mouse; nonhuman; priority journal; Aluminum; Animal; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Erythroid Progenitor Cells; Erythropoiesis; Erythropoietin; Mice; Support, Non-U.S. Gov't; Transferrin |
| Año: | 1994 |
| Volumen: | 20 |
| Número: | 3 |
| Página de inicio: | 141 |
| Página de fin: | 146 |
| Título revista: | Mineral and Electrolyte Metabolism |
| Título revista abreviado: | MINER. ELECTROLYTE METABOL. |
| ISSN: | 03780392 |
| CODEN: | MELMD |
| CAS: | aluminum, 7429-90-5; erythropoietin, 11096-26-7; transferrin, 82030-93-1; Aluminum, 7429-90-5; Erythropoietin, 11096-26-7; Transferrin, 11096-37-0 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03780392_v20_n3_p141_Garbossa |
Citas:
---------- APA ----------
Garbossa, G., Gutnisky, A. & Nesse, A. (1994) . The inhibitory action of aluminum on mouse bone marrow cell growth: Evidence for an erythropoietin- and transferrin-mediated mechanism. Mineral and Electrolyte Metabolism, 20(3), 141-146.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03780392_v20_n3_p141_Garbossa [ ]
---------- CHICAGO ----------
Garbossa, G., Gutnisky, A., Nesse, A. "The inhibitory action of aluminum on mouse bone marrow cell growth: Evidence for an erythropoietin- and transferrin-mediated mechanism" . Mineral and Electrolyte Metabolism 20, no. 3 (1994) : 141-146.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03780392_v20_n3_p141_Garbossa [ ]
---------- MLA ----------
Garbossa, G., Gutnisky, A., Nesse, A. "The inhibitory action of aluminum on mouse bone marrow cell growth: Evidence for an erythropoietin- and transferrin-mediated mechanism" . Mineral and Electrolyte Metabolism, vol. 20, no. 3, 1994, pp. 141-146.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03780392_v20_n3_p141_Garbossa [ ]
---------- VANCOUVER ----------
Garbossa, G., Gutnisky, A., Nesse, A. The inhibitory action of aluminum on mouse bone marrow cell growth: Evidence for an erythropoietin- and transferrin-mediated mechanism. MINER. ELECTROLYTE METABOL. 1994;20(3):141-146.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03780392_v20_n3_p141_Garbossa [ ]
