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Abstract:

The influence of the degree of sulfation of dermatan sulfate and condroitin sulfate C on their specific anticoagulant activities was studied under several different conditions of temperature, time of the reaction and method of sulfation. It is shown to be very important the use of an homogeneous reaction for sulfation, and very smooth conditions in order to avoid the hydrolysis of labile groups. The results confirm that the degree of sulfation is an important property of the CAGs and an increase of sulfation raises the specific anticoagulant activity of DS and CS-C.

Registro:

Documento: Artículo
Título:Influence of the degree of sulfation in the biological activity of dermatan sulfate and chondroitin sulfate C
Autor:Andoniades, S.E.; Schenone, M.; Recondo, E.F.; Fernández De Recondo, M.E.
Filiación:Departamento de Química Biológica, Universidad de Buenos Aires, Ciudad Universitaria, Nuñez (1428), Buenos Aires, Argentina
Departamento de Ciencias Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 954 (1111), Buenos Aires, Argentina
Año:2002
Volumen:90
Número:1-3
Página de inicio:21
Página de fin:26
Título revista:Anales des la Asociacion Quimica Argentina
Título revista abreviado:-
ISSN:03650375
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v90_n1-3_p21_Andoniades

Referencias:

  • Jackson, R.L., Bush, S.J., Cardin, A.D., (1991) Physiol. Rev., 71 (2), p. 481
  • Lindahl, U., (1989) Heparin: Chemical and Biological Properties, Clinical Applications, p. 159. , (Lane, D.A.; Lindahl, U., eds) Edward Arnold, London
  • Tollefsen, D.M., Majerus, D.W., Blank, M.K., (1982) J. Biol. Chem., 257, p. 2161
  • Hemker, H.C., Beguin, S., Kakkar, V.V., (1996) Haemostasis., 26, p. 117
  • Barrowcliffe, T.W., Johnson, T.E.A., Thomas, D.P., (1992) Low Molecular Weight Heparin, , Chichester, Wiley
  • Tollefsen, D.M., Blank, M.K., (1981) J. Clin. Invest., 68, p. 589
  • Scully, M.F., Ellis, V., Kakkar, V.V., (1986) Thromb. Res., 41, p. 489
  • Ofosu, F.A., Modi, G.J., Blajchman, M.A., Buchanan, M.R., Johnson, A., (1987) Biochem. J., 248, p. 889
  • Andoniades, S.E., Recondo, E.F., Fernández De Recondo, M.E., (1998) An. Asoc. Quim. Arg., 86, p. 243
  • Fernández De Recondo, M.E., Legorburu, C., Monge, J.C., Recondo, E.F., (1988) Biochem. Biophys. Res. Commun., 155 (1), p. 216
  • Fernández De Recondo, M.E., Monge, J.C., Recondo, E.F., (1995) Cell. Mol. Biol., 41 (4), p. 465
  • Calabrese, G.C., Recondo, M.M., Fernández De Recondo, M.E., Recondo, E.F., (1997) Cell. Mol. Biol., 43 (2), p. 237

Citas:

---------- APA ----------
Andoniades, S.E., Schenone, M., Recondo, E.F. & Fernández De Recondo, M.E. (2002) . Influence of the degree of sulfation in the biological activity of dermatan sulfate and chondroitin sulfate C . Anales des la Asociacion Quimica Argentina, 90(1-3), 21-26.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v90_n1-3_p21_Andoniades [ ]
---------- CHICAGO ----------
Andoniades, S.E., Schenone, M., Recondo, E.F., Fernández De Recondo, M.E. "Influence of the degree of sulfation in the biological activity of dermatan sulfate and chondroitin sulfate C " . Anales des la Asociacion Quimica Argentina 90, no. 1-3 (2002) : 21-26.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v90_n1-3_p21_Andoniades [ ]
---------- MLA ----------
Andoniades, S.E., Schenone, M., Recondo, E.F., Fernández De Recondo, M.E. "Influence of the degree of sulfation in the biological activity of dermatan sulfate and chondroitin sulfate C " . Anales des la Asociacion Quimica Argentina, vol. 90, no. 1-3, 2002, pp. 21-26.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v90_n1-3_p21_Andoniades [ ]
---------- VANCOUVER ----------
Andoniades, S.E., Schenone, M., Recondo, E.F., Fernández De Recondo, M.E. Influence of the degree of sulfation in the biological activity of dermatan sulfate and chondroitin sulfate C . -. 2002;90(1-3):21-26.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v90_n1-3_p21_Andoniades [ ]