Abstract:
The influence of the degree of sulfation of dermatan sulfate and condroitin sulfate C on their specific anticoagulant activities was studied under several different conditions of temperature, time of the reaction and method of sulfation. It is shown to be very important the use of an homogeneous reaction for sulfation, and very smooth conditions in order to avoid the hydrolysis of labile groups. The results confirm that the degree of sulfation is an important property of the CAGs and an increase of sulfation raises the specific anticoagulant activity of DS and CS-C.
Registro:
Documento: |
Artículo
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Título: | Influence of the degree of sulfation in the biological activity of dermatan sulfate and chondroitin sulfate C |
Autor: | Andoniades, S.E.; Schenone, M.; Recondo, E.F.; Fernández De Recondo, M.E. |
Filiación: | Departamento de Química Biológica, Universidad de Buenos Aires, Ciudad Universitaria, Nuñez (1428), Buenos Aires, Argentina Departamento de Ciencias Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 954 (1111), Buenos Aires, Argentina
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Año: | 2002
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Volumen: | 90
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Número: | 1-3
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Página de inicio: | 21
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Página de fin: | 26
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Título revista: | Anales des la Asociacion Quimica Argentina
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Título revista abreviado: | -
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ISSN: | 03650375
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v90_n1-3_p21_Andoniades |
Referencias:
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- Lindahl, U., (1989) Heparin: Chemical and Biological Properties, Clinical Applications, p. 159. , (Lane, D.A.; Lindahl, U., eds) Edward Arnold, London
- Tollefsen, D.M., Majerus, D.W., Blank, M.K., (1982) J. Biol. Chem., 257, p. 2161
- Hemker, H.C., Beguin, S., Kakkar, V.V., (1996) Haemostasis., 26, p. 117
- Barrowcliffe, T.W., Johnson, T.E.A., Thomas, D.P., (1992) Low Molecular Weight Heparin, , Chichester, Wiley
- Tollefsen, D.M., Blank, M.K., (1981) J. Clin. Invest., 68, p. 589
- Scully, M.F., Ellis, V., Kakkar, V.V., (1986) Thromb. Res., 41, p. 489
- Ofosu, F.A., Modi, G.J., Blajchman, M.A., Buchanan, M.R., Johnson, A., (1987) Biochem. J., 248, p. 889
- Andoniades, S.E., Recondo, E.F., Fernández De Recondo, M.E., (1998) An. Asoc. Quim. Arg., 86, p. 243
- Fernández De Recondo, M.E., Legorburu, C., Monge, J.C., Recondo, E.F., (1988) Biochem. Biophys. Res. Commun., 155 (1), p. 216
- Fernández De Recondo, M.E., Monge, J.C., Recondo, E.F., (1995) Cell. Mol. Biol., 41 (4), p. 465
- Calabrese, G.C., Recondo, M.M., Fernández De Recondo, M.E., Recondo, E.F., (1997) Cell. Mol. Biol., 43 (2), p. 237
Citas:
---------- APA ----------
Andoniades, S.E., Schenone, M., Recondo, E.F. & Fernández De Recondo, M.E.
(2002)
. Influence of the degree of sulfation in the biological activity of dermatan sulfate and chondroitin sulfate C . Anales des la Asociacion Quimica Argentina, 90(1-3), 21-26.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v90_n1-3_p21_Andoniades [ ]
---------- CHICAGO ----------
Andoniades, S.E., Schenone, M., Recondo, E.F., Fernández De Recondo, M.E.
"Influence of the degree of sulfation in the biological activity of dermatan sulfate and chondroitin sulfate C "
. Anales des la Asociacion Quimica Argentina 90, no. 1-3
(2002) : 21-26.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v90_n1-3_p21_Andoniades [ ]
---------- MLA ----------
Andoniades, S.E., Schenone, M., Recondo, E.F., Fernández De Recondo, M.E.
"Influence of the degree of sulfation in the biological activity of dermatan sulfate and chondroitin sulfate C "
. Anales des la Asociacion Quimica Argentina, vol. 90, no. 1-3, 2002, pp. 21-26.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v90_n1-3_p21_Andoniades [ ]
---------- VANCOUVER ----------
Andoniades, S.E., Schenone, M., Recondo, E.F., Fernández De Recondo, M.E. Influence of the degree of sulfation in the biological activity of dermatan sulfate and chondroitin sulfate C . -. 2002;90(1-3):21-26.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v90_n1-3_p21_Andoniades [ ]