Artículo

Pomilio, A.B.; Vitale, A.A.; Ciprian-Ollivier, J.; Cetkovich-Bakmas, M. "A chemical approach to the understanding of schizophrenia" (1998) Anales des la Asociacion Quimica Argentina. 86(3-6):320-335
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Abstract:

In this paper we show that the experimental psychosis observed after drinking Hoasca reproduces the pathologic transmethylation theory of schizophrenia. The occurrence of N,N-dimethyltryptamine (DMT) in the Hoasca drink and in the urine samples of subjects supports now that the chemical and neuropsychological effects are produced by this methylated indolealkylamine assisted by the β-carboline derivatives. These results further confirm that the urinary hallucinogenic compounds detected in healthy subjects (post-Hoasca, but not before) are the same as those found in the urine samples of acute psychotic unmedicated patients. The ability of Hoasca to modulate serotonergic receptors was evaluated, and thereby to which extent cortisol, prolactin and serotonin levels as well as perceptual and cognitive processes were affected. The degree of Hoasca monoamine oxidase (MAO) inhibition was directly correlated with the concentration of MAO-inhibiting β-carbolines. The additive combination of harmine and tetrahydroharmine (THH) accounts for the MAO inhibition exhibited by Hoasca.

Registro:

Documento: Artículo
Título:A chemical approach to the understanding of schizophrenia
Autor:Pomilio, A.B.; Vitale, A.A.; Ciprian-Ollivier, J.; Cetkovich-Bakmas, M.
Filiación:Departamento de Química Orgánica, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Departamento de Psiquiatría, Universidad de Buenos Aires, Centro de Psiquiatría Biológica, Francisco de Vittoria 2324, 1425 Buenos Aires, Argentina
Año:1998
Volumen:86
Número:3-6
Página de inicio:320
Página de fin:335
Título revista:Anales des la Asociacion Quimica Argentina
ISSN:03650375
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v86_n3-6_p320_Pomilio

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Citas:

---------- APA ----------
Pomilio, A.B., Vitale, A.A., Ciprian-Ollivier, J. & Cetkovich-Bakmas, M. (1998) . A chemical approach to the understanding of schizophrenia. Anales des la Asociacion Quimica Argentina, 86(3-6), 320-335.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v86_n3-6_p320_Pomilio [ ]
---------- CHICAGO ----------
Pomilio, A.B., Vitale, A.A., Ciprian-Ollivier, J., Cetkovich-Bakmas, M. "A chemical approach to the understanding of schizophrenia" . Anales des la Asociacion Quimica Argentina 86, no. 3-6 (1998) : 320-335.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v86_n3-6_p320_Pomilio [ ]
---------- MLA ----------
Pomilio, A.B., Vitale, A.A., Ciprian-Ollivier, J., Cetkovich-Bakmas, M. "A chemical approach to the understanding of schizophrenia" . Anales des la Asociacion Quimica Argentina, vol. 86, no. 3-6, 1998, pp. 320-335.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v86_n3-6_p320_Pomilio [ ]
---------- VANCOUVER ----------
Pomilio, A.B., Vitale, A.A., Ciprian-Ollivier, J., Cetkovich-Bakmas, M. A chemical approach to the understanding of schizophrenia. 1998;86(3-6):320-335.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03650375_v86_n3-6_p320_Pomilio [ ]