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Abstract:

The Blood-brain-barrier (BBB) provides both anatomical and physiological protection for the central nervous system (CNS), shielding the brain for toxic substances in the blood, supplying brain tissues with nutrients and filtering harmful compounds from the brain back to the bloodstream. The BBB is composed of four main cellular elements: endothelial cells (ECs), astrocyte end-feet, microglial cells, and perycites. Transport across the BBB is limited by both physical and metabolic barriers (enzymes, and different transport systems). Tight junctions (TJs) present between ECs form an important barrier against diffusion, excluding most blood-borne substances for entering the brain. © 2009 Springer Science+Business Media, LLC.

Registro:

Documento: Artículo
Título:Cellular elements of the blood-brain barrier
Autor:Correale, J.; Villa, A.
Filiación:Department of Neurology, Institute for Neurological Research Dr. Raúl Carrea (FLENI), Montañeses 2325, 1428 Buenos Aires, Argentina
School of Biomedical Sciences, Austral University, Montañeses 2325, 1428 Buenos Aires, Argentina
Department of Neurology, José María Ramos Mejía Hospital, School of Medicine Buenos Aires University, Urquiza 609, Buenos Aires 1221, Argentina
Palabras clave:Astrocytes; Basement membrane matrix; Blood brain barrier; Endothelial cells; Perycites; Transport; CD31 antigen; claudin; occludin; vascular endothelial cadherin; active transport; astrocyte; blood brain barrier; central nervous system; effusion; endocytosis; endothelium cell; human; ion transport; microglia; nonhuman; priority journal; review; tight junction; vascular endothelium; Adherens Junctions; Animals; Astrocytes; Blood-Brain Barrier; Carrier Proteins; Claudins; Endothelial Cells; Humans; Membrane Proteins; Microglia; Pericytes; Tight Junctions
Año:2009
Volumen:34
Número:12
Página de inicio:2067
Página de fin:2077
DOI: http://dx.doi.org/10.1007/s11064-009-0081-y
Título revista:Neurochemical Research
Título revista abreviado:Neurochem. Res.
ISSN:03643190
CODEN:NERED
CAS:occludin, 176304-61-3; Carrier Proteins; Claudins; Membrane Proteins; occludin
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03643190_v34_n12_p2067_Correale

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Citas:

---------- APA ----------
Correale, J. & Villa, A. (2009) . Cellular elements of the blood-brain barrier. Neurochemical Research, 34(12), 2067-2077.
http://dx.doi.org/10.1007/s11064-009-0081-y
---------- CHICAGO ----------
Correale, J., Villa, A. "Cellular elements of the blood-brain barrier" . Neurochemical Research 34, no. 12 (2009) : 2067-2077.
http://dx.doi.org/10.1007/s11064-009-0081-y
---------- MLA ----------
Correale, J., Villa, A. "Cellular elements of the blood-brain barrier" . Neurochemical Research, vol. 34, no. 12, 2009, pp. 2067-2077.
http://dx.doi.org/10.1007/s11064-009-0081-y
---------- VANCOUVER ----------
Correale, J., Villa, A. Cellular elements of the blood-brain barrier. Neurochem. Res. 2009;34(12):2067-2077.
http://dx.doi.org/10.1007/s11064-009-0081-y