Artículo
Merello, M.; Nouzeilles, M.I.; Cammarota, A.; Leiguarda, R. "Effect of memantine (NMDA antagonist) on Parkinson's disease: A double- blind crossover randomized study" (1999) Clinical Neuropharmacology. 22(5):273-276
Estamos trabajando para incorporar este artículo al repositorio
Consulte la política de Acceso Abierto del editor
Abstract:
Our aim was to evaluate the effect of Memantine (1-amino 3,5- dimethyladamantane hydrochloride) on cardinal symptoms of Parkinson's disease and on the latency, duration, and magnitude of the response to a single close of L-Dopa and on drug-induced dyskinesias. Twelve Hoehn-Yahr III-IV patients with idiopathic Parkinson's disease with motor fluctuations and drug-induced dyskinesias were randomized to the NMDA antagonist memantine or placebo in a cross-over design. A single-close L-Dopa challenge was performed after each medication arm. A significant drug effect on the Unified Parkinson's Disease Rating Scale motor score was observed in 'off' and 'on' states (F(1,11) = 13.5;p < 0.003). No significant effect on drug-induced dyskinesias was seen. The results suggest that memantine may improve parkinsonian symptoms independently of dopaminergic drugs and, in contrast to recent findings with amantadine, it has no effect on drug-induced dyskinesias.
Registro:
| Documento: | Artículo |
| Título: | Effect of memantine (NMDA antagonist) on Parkinson's disease: A double- blind crossover randomized study |
| Autor: | Merello, M.; Nouzeilles, M.I.; Cammarota, A.; Leiguarda, R. |
| Filiación: | Movement Disorders Section, Neurology Department, Raul Carrea Inst. for Neurol. Res., Buenos Aires, Argentina Movement Disorders Section, Raul Carrea Inst. for Neurol. Res., Montañeses 2325, (1428) Buenos Aires, Argentina |
| Palabras clave: | Memantine; NMDA; Parkinson's disease; amantadine; levodopa; memantine; n methyl dextro aspartic acid receptor blocking agent; placebo; adult; aged; article; clinical trial; controlled clinical trial; controlled study; crossover procedure; dopaminergic system; drowsiness; drug effect; dyskinesia; female; human; male; motor performance; nausea; Parkinson disease; priority journal; randomized controlled trial; Aged; Antiparkinson Agents; Cross-Over Studies; Double-Blind Method; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Memantine; Middle Aged; N-Methylaspartate; Parkinson Disease; Severity of Illness Index; Treatment Outcome |
| Año: | 1999 |
| Volumen: | 22 |
| Número: | 5 |
| Página de inicio: | 273 |
| Página de fin: | 276 |
| Título revista: | Clinical Neuropharmacology |
| Título revista abreviado: | Clin. Neuropharmacol. |
| ISSN: | 03625664 |
| CODEN: | CLNED |
| CAS: | Antiparkinson Agents; Levodopa; Memantine, 19982-08-2; N-Methylaspartate, 6384-92-5 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03625664_v22_n5_p273_Merello |
Referencias:
- Shannon, K.M., Goetz, C.G., Carroll, V.S., Tanner, C.M., Klawans, H.L., Amantadine and motor fluctuations in chronic Parkinson's disease (1987) Clin Neuropharmacol, 10, pp. 522-526
- Verhagen Metman, L., Del Dotto, P., Van Den Munckholf, P., Fang, J., Mouradian, M., Chase, T., Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease (1998) Neurology, 50, pp. 1323-1326
- Bormann, J., Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channel (1989) Eur J Pharmacol, 66, pp. 591-592
- Rabey, J.M., Nissipeanu, P., Korczyn, A.D., Efficacy of memantine, an NMDA receptor antagonist in the treatment of Parkinson's disease (1992) J Neural Transm, 4, pp. 277-282
- Papa, S.M., Chase, T., Levodopa-induced dyskinesias improved by a glutamate antagonist in parkinsonian monkeys (1996) Ann Neurol, 39, pp. 574-578
- Blanchet, P., Verhagen Metman, L., Mouradian, M., Chase, T., Acute pharmacological blockade of dyskinesias in Parkinson's disease (1996) Mov Disord, 11, pp. 580-581
- Verhagen Metman, L., Del Dotto, P., Natte, R., Van Den Munckholf, P., Chase, T., Dextrometorphan improves levodopa induced dyskinesias in Parkinson's disease (1998) Neurology, 51, pp. 203-206
- Greenamyre, J.T., Pharmacological pallidotomy with glutamate antagonists? (1996) Ann Neurol, 39, pp. 557-558
- Klockgether, T., Turski, L., Toward an understanding of the role of glutamate in experimental parkinsonism: Agonist sensitive sites in the basal ganglia (1993) Ann Neurol, 34, pp. 585-593
- Greenamyre, J.T., Eller, R.V., Zhang, Z., Ovadia, A., Kurlan, R., Gash, D.M., Antiparkinsonian effect of racemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson disease (1994) Ann Neurol, 35, pp. 655-661
- Carlsson, M., Carlsson, A., Interactions between glutamatergic and monoaminergic systems within the basal ganglia: Implication for schizophrenia and Parkinson's disease (1990) Trends Neurosci, 13, pp. 272-276
Citas:
---------- APA ----------
Merello, M., Nouzeilles, M.I., Cammarota, A. & Leiguarda, R. (1999) . Effect of memantine (NMDA antagonist) on Parkinson's disease: A double- blind crossover randomized study. Clinical Neuropharmacology, 22(5), 273-276.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03625664_v22_n5_p273_Merello [ ]
---------- CHICAGO ----------
Merello, M., Nouzeilles, M.I., Cammarota, A., Leiguarda, R. "Effect of memantine (NMDA antagonist) on Parkinson's disease: A double- blind crossover randomized study" . Clinical Neuropharmacology 22, no. 5 (1999) : 273-276.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03625664_v22_n5_p273_Merello [ ]
---------- MLA ----------
Merello, M., Nouzeilles, M.I., Cammarota, A., Leiguarda, R. "Effect of memantine (NMDA antagonist) on Parkinson's disease: A double- blind crossover randomized study" . Clinical Neuropharmacology, vol. 22, no. 5, 1999, pp. 273-276.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03625664_v22_n5_p273_Merello [ ]
---------- VANCOUVER ----------
Merello, M., Nouzeilles, M.I., Cammarota, A., Leiguarda, R. Effect of memantine (NMDA antagonist) on Parkinson's disease: A double- blind crossover randomized study. Clin. Neuropharmacol. 1999;22(5):273-276.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03625664_v22_n5_p273_Merello [ ]
