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Abstract:

Twelve parkinsonian patients with severely fluctuating symptoms were given a single dose of apomorphine or Dispersible Madopar on 2 consecutive days, to confirm the latter drug's usefulness in 'off' period rescue. According to our results, apomorphine proved faster in reverting 'off' periods and should still be regarded as the drug of choice for this treatment modality.

Registro:

Documento: Artículo
Título:Comparison of subcutaneous apomorphine versus dispersible madopar latency and effect duration in parkinson's disease patients: A double-blind single-dose study
Autor:Merello, M.; Pikielny, R.; Cammarota, A.; Leiguarda, R.
Filiación:Movement Disorders Section, Neurology Department, Raul Carrea Inst. for Neurol. Res., Buenos Aires, Argentina
Movement Disorders Section, Raul Carrea Inst. for Neurol. Res., Montañeses 2325, 1428 Buenos Aires, Argentina
Palabras clave:'On-off' periods; Apomorphine; Dispersible Madopar; Motor fluctuation; Parkinson's disease; apomorphine; benserazide plus levodopa; britaject; levodopa; unclassified drug; adult; article; clinical article; clinical trial; controlled clinical trial; controlled study; double blind procedure; female; human; male; motor dysfunction; on off phenomenon; Parkinson disease; priority journal; subcutaneous drug administration
Año:1997
Volumen:20
Número:2
Página de inicio:165
Página de fin:167
DOI: http://dx.doi.org/10.1097/00002826-199704000-00008
Título revista:Clinical Neuropharmacology
Título revista abreviado:CLIN. NEUROPHARMACOL.
ISSN:03625664
CODEN:CLNED
CAS:apomorphine, 314-19-2, 58-00-4; benserazide plus levodopa, 37270-69-2; levodopa, 59-92-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03625664_v20_n2_p165_Merello

Referencias:

  • Marsden, C.D., Parkes, J.D., "On-off" effects in patients with Parkinson's disease on chronic levodopa therapy (1976) Lancet, 1, pp. 292-296
  • Steiger, M.J., Stocchi, F., Bramante, L., Ruggieri, S., Quinn, N.P., The clinical efficacy of single morning dose of levodopa methyl ester: Dispersible Madopar and Sinernet plus in Parkinson's disease (1992) Clin Neuropharmacol, 15, pp. 501-504
  • Steiger, M.J., Stocchi, F., Carta, A., Ruggieri, S., Agnoli, A., Quinn, N.P., Marsden, C.D., The clinical efficacy of oral levodopa methyl ester solution in reversing afternoon "off" periods in Parkinson's disease (1991) Clin Neuropharmacol, 14, pp. 241-244
  • Stibe, C.M.H., Kempster, P.A., Lees, A.J., Stern, G.M., Subcutaneous apomorphine in parkinsonian on-off oscillations (1988) Lancet, 1, pp. 403-406
  • Cooper, D.R., Marrel, C., Testa, B., L-dopa methyl-ester: A candidate for chronic systemic delivery of L-dopa in Parkinson's disease (1984) Clin Neuropharmacol, 7, pp. 89-98
  • Stibe, C.M.H., Lees, A.J., Stern, G.M., Subcutaneous infusion of apomorphine and lisuride in the treatment of parkinsonian on-off fluctuation (1987) Lancet, 1, p. 871
  • Le Witt, P.A., Ward, C.D., Larsen, T.A., Comparison of pergolide and bromocriptine therapy in parkinsonism (1983) Neurology, 33, pp. 1009-1014
  • Hardie, R.J., Lee, A.J., Stern, G.M., On-off fluctuations in Parkinson's disease: A clinical and neuropharmacology studs (1984) Brain, 107, pp. 487-506

Citas:

---------- APA ----------
Merello, M., Pikielny, R., Cammarota, A. & Leiguarda, R. (1997) . Comparison of subcutaneous apomorphine versus dispersible madopar latency and effect duration in parkinson's disease patients: A double-blind single-dose study. Clinical Neuropharmacology, 20(2), 165-167.
http://dx.doi.org/10.1097/00002826-199704000-00008
---------- CHICAGO ----------
Merello, M., Pikielny, R., Cammarota, A., Leiguarda, R. "Comparison of subcutaneous apomorphine versus dispersible madopar latency and effect duration in parkinson's disease patients: A double-blind single-dose study" . Clinical Neuropharmacology 20, no. 2 (1997) : 165-167.
http://dx.doi.org/10.1097/00002826-199704000-00008
---------- MLA ----------
Merello, M., Pikielny, R., Cammarota, A., Leiguarda, R. "Comparison of subcutaneous apomorphine versus dispersible madopar latency and effect duration in parkinson's disease patients: A double-blind single-dose study" . Clinical Neuropharmacology, vol. 20, no. 2, 1997, pp. 165-167.
http://dx.doi.org/10.1097/00002826-199704000-00008
---------- VANCOUVER ----------
Merello, M., Pikielny, R., Cammarota, A., Leiguarda, R. Comparison of subcutaneous apomorphine versus dispersible madopar latency and effect duration in parkinson's disease patients: A double-blind single-dose study. CLIN. NEUROPHARMACOL. 1997;20(2):165-167.
http://dx.doi.org/10.1097/00002826-199704000-00008