Artículo
Merello, M.; Starkstein, S.; Petracca, G.; Cataneo, E.A.; Manes, F.; Leiguarda, R. "Drug-induced parkinsonism in schizophrenic patients: Motor response and psychiatric changes after acute challenge with L-Dopa and apomorphine" (1996) Clinical Neuropharmacology. 19(5):439-443
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Abstract:
Acute single-dose response of drug-induced parkinsonism (DIP) to L-Dopa and apomorphine challenge was evaluated in a double-blind crossover study in 12 schizophrenic patients. There were two noteworthy negative findings. First, neither L-Dopa nor apomorphine produced significant improvements in DIP and second, no changes (neither improvement nor worsening) were found in patients' psychiatric status. Findings suggest that, for a stimulation dose reaching almost 90% of the responsive dose for idiopathic Parkinson's disease, no significant changes may reasonably be expected in the parkinsonism of schizophrenic patients treated with neuroleptic drugs.
Registro:
| Documento: | Artículo |
| Título: | Drug-induced parkinsonism in schizophrenic patients: Motor response and psychiatric changes after acute challenge with L-Dopa and apomorphine |
| Autor: | Merello, M.; Starkstein, S.; Petracca, G.; Cataneo, E.A.; Manes, F.; Leiguarda, R. |
| Filiación: | Department of Clinical Neurology, Raul Carrea Institute, Neurological Research FLENI, Buenos Aires, Argentina Movement Disorders Section, Raul Carrea Institute, Neurological Research FLENI, Buenos Aires, Argentina Department of Psychiatry, Raul Carrea Institute, Neurological Research FLENI, Buenos Aires, Argentina Melchor Romero, Neuropsychiatric H., Raul Carrea Institute, Neurological Research FLENI, Buenos Aires, Argentina Movement Disorders Section, FLEN1, Montaneses 2325, 1428 Buenos Aires, Argentina |
| Palabras clave: | Acute challenge; Apomorphine; Drug-induced parkinsonism; L-Dopa; Neuroleptic drugs; Secondary parkinsonism; antiparkinson agent; apomorphine; carbidopa; chlorpromazine; dopamine receptor stimulating agent; haloperidol; levodopa; levomepromazine; neuroleptic agent; placebo; promethazine; thioridazine; adult; article; clinical article; clinical trial; controlled clinical trial; controlled study; crossover procedure; double blind procedure; drug induced disease; extrapyramidal symptom; female; human; mental disease; motor performance; parkinsonism; priority journal; schizophrenia; treatment outcome |
| Año: | 1996 |
| Volumen: | 19 |
| Número: | 5 |
| Página de inicio: | 439 |
| Página de fin: | 443 |
| DOI: | http://dx.doi.org/10.1097/00002826-199619050-00007 |
| Título revista: | Clinical Neuropharmacology |
| Título revista abreviado: | CLIN. NEUROPHARMACOL. |
| ISSN: | 03625664 |
| CODEN: | CLNED |
| CAS: | apomorphine, 314-19-2, 58-00-4; carbidopa, 28860-95-9, 38821-49-7; chlorpromazine, 50-53-3, 69-09-0; haloperidol, 52-86-8, 1511-16-6; levodopa, 59-92-7; levomepromazine, 1236-99-3, 60-99-1, 7104-38-3; promethazine, 58-33-3, 60-87-7; thioridazine, 130-61-0, 50-52-2 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03625664_v19_n5_p439_Merello |
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Citas:
---------- APA ----------
Merello, M., Starkstein, S., Petracca, G., Cataneo, E.A., Manes, F. & Leiguarda, R. (1996) . Drug-induced parkinsonism in schizophrenic patients: Motor response and psychiatric changes after acute challenge with L-Dopa and apomorphine. Clinical Neuropharmacology, 19(5), 439-443.http://dx.doi.org/10.1097/00002826-199619050-00007
---------- CHICAGO ----------
Merello, M., Starkstein, S., Petracca, G., Cataneo, E.A., Manes, F., Leiguarda, R. "Drug-induced parkinsonism in schizophrenic patients: Motor response and psychiatric changes after acute challenge with L-Dopa and apomorphine" . Clinical Neuropharmacology 19, no. 5 (1996) : 439-443.http://dx.doi.org/10.1097/00002826-199619050-00007
---------- MLA ----------
Merello, M., Starkstein, S., Petracca, G., Cataneo, E.A., Manes, F., Leiguarda, R. "Drug-induced parkinsonism in schizophrenic patients: Motor response and psychiatric changes after acute challenge with L-Dopa and apomorphine" . Clinical Neuropharmacology, vol. 19, no. 5, 1996, pp. 439-443.http://dx.doi.org/10.1097/00002826-199619050-00007
---------- VANCOUVER ----------
Merello, M., Starkstein, S., Petracca, G., Cataneo, E.A., Manes, F., Leiguarda, R. Drug-induced parkinsonism in schizophrenic patients: Motor response and psychiatric changes after acute challenge with L-Dopa and apomorphine. CLIN. NEUROPHARMACOL. 1996;19(5):439-443.http://dx.doi.org/10.1097/00002826-199619050-00007
