Abstract:
The synthesis and spectral properties (MS, and NMR) of radioiodinated β-carbolines: 6-(I) and 8-(II) [131I]-iodo-1-methyl-7-methoxy-β-carboline ([131I]-iodo-harmine), 6-(III) and 8-(IV) [131I]-iodo-1-methyl-β-carboline-7-ol([131I]-iodo-harmol), 8-[131I]-iodo-1-methyl-7-methoxy-3,4-dihydro-β-carboline (8-[131I]-iodo-harmaline) (V), 8-[131I]-iodo-3,4-dihydro-1-methyl-β-carboline-7-ol (8-[131I]-iodo-harmalol) (VI), 6-[131I]-iodo-1-methyl-β-carboline (6-[131I]-iodo-harmane) (VII) are described. These are compounds of biological importance and can be used for brain mapping with SPECT technology.
Registro:
| Documento: |
Artículo
|
| Título: | Iodination, radioiodination and spectroscopic identification of β-carboline derivatives |
| Autor: | Sintas, J.A.; Vitale, A.A. |
| Filiación: | PROPLAME-CONICET, Depto. de Quim. Orgánica, Universidad de Buenos Aires, Pabellón 2, Ciudad U., 1428 Buenos Aires, Argentina
|
| Palabras clave: | [131I]-iodo-β-carbolines; Preparation and characterization; amine oxidase (flavin containing); beta carboline derivative; harmine; article; brain mapping; human; iodination; mass spectrometry; nuclear magnetic resonance spectroscopy; radioiodination; single photon emission computer tomography; synthesis |
| Año: | 1999
|
| Volumen: | 42
|
| Número: | 5
|
| Página de inicio: | 409
|
| Página de fin: | 413
|
| DOI: |
http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A |
| Título revista: | Journal of Labelled Compounds and Radiopharmaceuticals
|
| Título revista abreviado: | J. Label. Compd. Radiopharm.
|
| ISSN: | 03624803
|
| CODEN: | JLCRD
|
| CAS: | amine oxidase (flavin containing), 37255-42-8, 9001-66-5, 9059-11-4; harmine, 343-27-1, 442-51-3
|
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03624803_v42_n5_p409_Sintas |
Referencias:
- Shih, J.C., (1979) Monoaminooxidase; Structure, Junction, and Altered Function, , New York: Academic Press
- Oreland, L., Arai, Y., Stenström, A., (1984) Monoaminooxidase and Disease, , London: Academic Press
- Fowler, C.J., Wiberg, A., Oreland, L., (1980) J. Neural. Transm., 49, p. 1
- Eckert, B., Gottfries, C.G., Von Knorring, L., (1980) Progr. Neuro-psychopharmacol., 4, p. 57
- Seeman, P., (1980) Pharmacol. Rev., 32, p. 229
- Pawlik, M., Kaulen, P., Baumgarten, H.G., Rommelspacher, H., (1990) J. Chem Neuroanal., 3 (1), p. 19
- Sintas, J.A., Vitale, A.A., (1997) J. Labelled Cpd. Radiopharm., 39, p. 677
- Sintas, J.A., Vitale, A.A., (1998) J. Labelled Cpd. Radiopharm., 41, p. 53
- McKillop, A., Hunt, J.D., Zelesko, M.J., (1971) J. Am. Chem Soc., 93, p. 4841
Citas:
---------- APA ----------
Sintas, J.A. & Vitale, A.A.
(1999)
. Iodination, radioiodination and spectroscopic identification of β-carboline derivatives. Journal of Labelled Compounds and Radiopharmaceuticals, 42(5), 409-413.
http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A---------- CHICAGO ----------
Sintas, J.A., Vitale, A.A.
"Iodination, radioiodination and spectroscopic identification of β-carboline derivatives"
. Journal of Labelled Compounds and Radiopharmaceuticals 42, no. 5
(1999) : 409-413.
http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A---------- MLA ----------
Sintas, J.A., Vitale, A.A.
"Iodination, radioiodination and spectroscopic identification of β-carboline derivatives"
. Journal of Labelled Compounds and Radiopharmaceuticals, vol. 42, no. 5, 1999, pp. 409-413.
http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A---------- VANCOUVER ----------
Sintas, J.A., Vitale, A.A. Iodination, radioiodination and spectroscopic identification of β-carboline derivatives. J. Label. Compd. Radiopharm. 1999;42(5):409-413.
http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A
