Abstract:
The synthesis and spectral properties (MS, and NMR) of radioiodinated β-carbolines: 6-(I) and 8-(II) [131I]-iodo-1-methyl-7-methoxy-β-carboline ([131I]-iodo-harmine), 6-(III) and 8-(IV) [131I]-iodo-1-methyl-β-carboline-7-ol([131I]-iodo-harmol), 8-[131I]-iodo-1-methyl-7-methoxy-3,4-dihydro-β-carboline (8-[131I]-iodo-harmaline) (V), 8-[131I]-iodo-3,4-dihydro-1-methyl-β-carboline-7-ol (8-[131I]-iodo-harmalol) (VI), 6-[131I]-iodo-1-methyl-β-carboline (6-[131I]-iodo-harmane) (VII) are described. These are compounds of biological importance and can be used for brain mapping with SPECT technology.
Registro:
Documento: |
Artículo
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Título: | Iodination, radioiodination and spectroscopic identification of β-carboline derivatives |
Autor: | Sintas, J.A.; Vitale, A.A. |
Filiación: | PROPLAME-CONICET, Depto. de Quim. Orgánica, Universidad de Buenos Aires, Pabellón 2, Ciudad U., 1428 Buenos Aires, Argentina
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Palabras clave: | [131I]-iodo-β-carbolines; Preparation and characterization; amine oxidase (flavin containing); beta carboline derivative; harmine; article; brain mapping; human; iodination; mass spectrometry; nuclear magnetic resonance spectroscopy; radioiodination; single photon emission computer tomography; synthesis |
Año: | 1999
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Volumen: | 42
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Número: | 5
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Página de inicio: | 409
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Página de fin: | 413
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DOI: |
http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A |
Título revista: | Journal of Labelled Compounds and Radiopharmaceuticals
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Título revista abreviado: | J. Label. Compd. Radiopharm.
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ISSN: | 03624803
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CODEN: | JLCRD
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CAS: | amine oxidase (flavin containing), 37255-42-8, 9001-66-5, 9059-11-4; harmine, 343-27-1, 442-51-3
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03624803_v42_n5_p409_Sintas |
Referencias:
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Citas:
---------- APA ----------
Sintas, J.A. & Vitale, A.A.
(1999)
. Iodination, radioiodination and spectroscopic identification of β-carboline derivatives. Journal of Labelled Compounds and Radiopharmaceuticals, 42(5), 409-413.
http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A---------- CHICAGO ----------
Sintas, J.A., Vitale, A.A.
"Iodination, radioiodination and spectroscopic identification of β-carboline derivatives"
. Journal of Labelled Compounds and Radiopharmaceuticals 42, no. 5
(1999) : 409-413.
http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A---------- MLA ----------
Sintas, J.A., Vitale, A.A.
"Iodination, radioiodination and spectroscopic identification of β-carboline derivatives"
. Journal of Labelled Compounds and Radiopharmaceuticals, vol. 42, no. 5, 1999, pp. 409-413.
http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A---------- VANCOUVER ----------
Sintas, J.A., Vitale, A.A. Iodination, radioiodination and spectroscopic identification of β-carboline derivatives. J. Label. Compd. Radiopharm. 1999;42(5):409-413.
http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A