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Abstract:

The synthesis and spectral properties (MS, and NMR) of radioiodinated β-carbolines: 6-(I) and 8-(II) [131I]-iodo-1-methyl-7-methoxy-β-carboline ([131I]-iodo-harmine), 6-(III) and 8-(IV) [131I]-iodo-1-methyl-β-carboline-7-ol([131I]-iodo-harmol), 8-[131I]-iodo-1-methyl-7-methoxy-3,4-dihydro-β-carboline (8-[131I]-iodo-harmaline) (V), 8-[131I]-iodo-3,4-dihydro-1-methyl-β-carboline-7-ol (8-[131I]-iodo-harmalol) (VI), 6-[131I]-iodo-1-methyl-β-carboline (6-[131I]-iodo-harmane) (VII) are described. These are compounds of biological importance and can be used for brain mapping with SPECT technology.

Registro:

Documento: Artículo
Título:Iodination, radioiodination and spectroscopic identification of β-carboline derivatives
Autor:Sintas, J.A.; Vitale, A.A.
Filiación:PROPLAME-CONICET, Depto. de Quim. Orgánica, Universidad de Buenos Aires, Pabellón 2, Ciudad U., 1428 Buenos Aires, Argentina
Palabras clave:[131I]-iodo-β-carbolines; Preparation and characterization; amine oxidase (flavin containing); beta carboline derivative; harmine; article; brain mapping; human; iodination; mass spectrometry; nuclear magnetic resonance spectroscopy; radioiodination; single photon emission computer tomography; synthesis
Año:1999
Volumen:42
Número:5
Página de inicio:409
Página de fin:413
DOI: http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A
Título revista:Journal of Labelled Compounds and Radiopharmaceuticals
Título revista abreviado:J. Label. Compd. Radiopharm.
ISSN:03624803
CODEN:JLCRD
CAS:amine oxidase (flavin containing), 37255-42-8, 9001-66-5, 9059-11-4; harmine, 343-27-1, 442-51-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03624803_v42_n5_p409_Sintas

Referencias:

  • Shih, J.C., (1979) Monoaminooxidase; Structure, Junction, and Altered Function, , New York: Academic Press
  • Oreland, L., Arai, Y., Stenström, A., (1984) Monoaminooxidase and Disease, , London: Academic Press
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  • Sintas, J.A., Vitale, A.A., (1997) J. Labelled Cpd. Radiopharm., 39, p. 677
  • Sintas, J.A., Vitale, A.A., (1998) J. Labelled Cpd. Radiopharm., 41, p. 53
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Citas:

---------- APA ----------
Sintas, J.A. & Vitale, A.A. (1999) . Iodination, radioiodination and spectroscopic identification of β-carboline derivatives. Journal of Labelled Compounds and Radiopharmaceuticals, 42(5), 409-413.
http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A
---------- CHICAGO ----------
Sintas, J.A., Vitale, A.A. "Iodination, radioiodination and spectroscopic identification of β-carboline derivatives" . Journal of Labelled Compounds and Radiopharmaceuticals 42, no. 5 (1999) : 409-413.
http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A
---------- MLA ----------
Sintas, J.A., Vitale, A.A. "Iodination, radioiodination and spectroscopic identification of β-carboline derivatives" . Journal of Labelled Compounds and Radiopharmaceuticals, vol. 42, no. 5, 1999, pp. 409-413.
http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A
---------- VANCOUVER ----------
Sintas, J.A., Vitale, A.A. Iodination, radioiodination and spectroscopic identification of β-carboline derivatives. J. Label. Compd. Radiopharm. 1999;42(5):409-413.
http://dx.doi.org/10.1002/(SICI)1099-1344(199905)42:5<409::AID-JLCR195>3.0.CO;2-A