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Abstract:

The synthesis and spectral properties of new radioiodinated phenylalkylamines like 2-[131I]-iodo-4,5-dimethoxyphenethylamine, 2- [131I]-iodo-4,5-dimethoxy-N,N-dimethylphenethylamine 2-[131I]- iodophenethylamine, 2-[131I]-iodo-N,N-dimethylphenethylamine, 2-[131I]- iodo-3,4,5-trimethoxy-phenethylamine (mescaline) are described for the first time. These compounds are of biological importance and can be used for brain mapping with SPECT technology.

Registro:

Documento: Artículo
Título:Synthesis of derivatives of [I-131] phenylalkylamines for brain mapping
Autor:Sintas, J.A.; Vitale, A.A.
Filiación:PROPLAME-CONICET, Depto. de Quim. Orgánica, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:2- [131I]-iodo-N,N-dimethylphenethylamine; 2-[131I]- iodomescaline; 2-[131I]-iodo-4,5- dimethoxy-N,N-dimethylphenethylamine; 2-[131I]-Iodo-4,5-dimethoxyphenethylamine; 2-[131I]-iodophenethylamine; phenethylamines; 2 iodo 3,4,5 trimethoxy phenethylamine i 131; 2 iodo 4,5 dimethoxy n,n dimethylphenethylamine i 131; 2 iodo 4,5 dimethoxyphenethylamine i 131; 2 iodo n,n dimethylphenethylamine i 131; 2 iodomescaline i 131; 2 iodophenethylamine i 131; iodine 131; phenethylamine derivative; phenylalkylamine; unclassified drug; article; brain mapping; diagnostic imaging; iodination; mental disease; radioiodination; single photon emission computer tomography; synthesis; thin layer chromatography
Año:1998
Volumen:41
Número:1
Página de inicio:53
Página de fin:61
DOI: http://dx.doi.org/10.1002/(SICI)1099-1344(199801)41:1<53::AID-JLCR53>3.0.CO;2-K
Título revista:Journal of Labelled Compounds and Radiopharmaceuticals
Título revista abreviado:J. Label. Compd. Radiopharm.
ISSN:03624803
CODEN:JLCRD
CAS:iodine 131, 10043-66-0, 15124-39-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03624803_v41_n1_p53_Sintas

Referencias:

  • Dewhurst, W.G., (1968) Nature, 218, p. 1130
  • Oberlender, R.A., Kothari, P.A., Nichols, D.E., (1984) J. Med. Chem, 27, p. 788
  • Shulgin, A.T., Hallucinogens (1981) Burger's Medicinal Chemistry, 4th Ed., , Wolff, M. E. New York; Wiley and Co
  • Murphy, D.L., Garrick, N.A., Aulakh, C.S., (1984) J. Clin. Psychiat., 47, p. 37
  • Shih, J.C., (1979) Monoaminooxidase; Structure, Function, and Altered Function, , New York: Academic Press
  • Oreland, L., Arai, Y., Stenström, A., (1984) Monoaminooxidase and Disease, , London: Academic Press
  • Fowler, C.J., Wiberg, A., Oreland, L., (1980) J. Neural. Transm., 49, p. 1
  • Eckert, B., Gottfries, C.G., Von Knorring, L., (1980) Progr. Neuro-Psychopharmacol., 4, p. 57
  • Seeman, P., (1980) Pharmacol. Rev., 32, p. 229
  • Seeman, P., Niznik, H.B., (1990) FASEB J., 4, p. 2737
  • Winchell, H.S., Baldwin, R.M., Lin, T.H., (1980) J. Nucl. Med., 21, p. 940
  • Vitale, A.A., Calviño, M.A., Ferrari, C.C., Stahl, A.E., Pomilio, A.B., (1995) J. Lab. Comp. Radiopharm., 36, p. 509
  • Gottlieb, A., (1977) Peyote and Other Psychoactive Cacti. Kistone Press
  • Nichols, D.E., Kostuba, L.J., (1979) J. Med. Chem, 22, p. 1264
  • Glennon, R.A., Liebowitz, S.M., Leming-Doot, D., (1980) J. Med. Chem., 23, p. 990
  • Comins, D.L., Brown, J.D., (1984) J. Org. Chem., 49, p. 1078
  • Johnson, M.J., Frescas, S.P., Oberlender, R., Nichols, D.E., (1991) J. Med. Chem., 34, p. 1662
  • Zweig, J., Castagnoli, N., (1977) J. Med. Chem., 20, p. 414
  • Banholzer, K., Campbell, T.W., Schmid, H., (1952) Helv. Chim. Acta., 35, p. 1577
  • Hadáçek, J., Michakský, J., Malcholán, L., (1955) Chem. Listy., 49, p. 271
  • Edgar, K.J., Falling, S.N., (1990) J. Med. Chem, 18, p. 5287
  • Billings, R., Kung, M.P., Chumpradit, S., (1991) J. Neurochem., 58, p. 227
  • Chumpradit, S.J., Kung, M.P., Billings, R., (1993) J. Med. Chem., 36, p. 221
  • He, X., Matecka, D., Lee, K.S., Gu, Z., (1994) J. Lab. Comp. Radiopharm., 34, p. 27
  • McPherson, D.W., Knapp, F.F., Hudkins, R.L., (1994) J. Lab. Comp. Radiopharm., 34, p. 239
  • Mathis, C.A., Enas, J.D., Hanrahan, S.M., (1994) J. Lab. Comp. Radiopharm., 34, p. 905
  • Eggler, J.F., Cheng, J.B., Cooper, K., Hanak, L.M., (1994) J. Lab. Comp. Radiopharm., 34, p. 1147
  • Sintas, J.A., Vitale, A.A., (1997) J. Lab Comp. Radiopharm., , In press
  • McKillop, A., Hunt, J.D., Zelesko, M.J., (1971) J. Am. Chem Soc., 93, p. 4841

Citas:

---------- APA ----------
Sintas, J.A. & Vitale, A.A. (1998) . Synthesis of derivatives of [I-131] phenylalkylamines for brain mapping. Journal of Labelled Compounds and Radiopharmaceuticals, 41(1), 53-61.
http://dx.doi.org/10.1002/(SICI)1099-1344(199801)41:1<53::AID-JLCR53>3.0.CO;2-K
---------- CHICAGO ----------
Sintas, J.A., Vitale, A.A. "Synthesis of derivatives of [I-131] phenylalkylamines for brain mapping" . Journal of Labelled Compounds and Radiopharmaceuticals 41, no. 1 (1998) : 53-61.
http://dx.doi.org/10.1002/(SICI)1099-1344(199801)41:1<53::AID-JLCR53>3.0.CO;2-K
---------- MLA ----------
Sintas, J.A., Vitale, A.A. "Synthesis of derivatives of [I-131] phenylalkylamines for brain mapping" . Journal of Labelled Compounds and Radiopharmaceuticals, vol. 41, no. 1, 1998, pp. 53-61.
http://dx.doi.org/10.1002/(SICI)1099-1344(199801)41:1<53::AID-JLCR53>3.0.CO;2-K
---------- VANCOUVER ----------
Sintas, J.A., Vitale, A.A. Synthesis of derivatives of [I-131] phenylalkylamines for brain mapping. J. Label. Compd. Radiopharm. 1998;41(1):53-61.
http://dx.doi.org/10.1002/(SICI)1099-1344(199801)41:1<53::AID-JLCR53>3.0.CO;2-K