Artículo
Sintas, J.A.; Vitale, A.A. "Synthesis of 131I derivatives of indolealkylamines for brain mapping" (1997) Journal of Labelled Compounds and Radiopharmaceuticals. 39(8):677-684
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Abstract:
The synthesis and spectral properties of new radioiodinated indolealkylamines like 2-[131 I]-iodo-N,N-dimethyltryptamine, 2-[131 I]-iodo-N-methyltryptamine, 2-[131 I]-iodo-5-methoxy-N,N-dimethyltryptamine, 2-[131 I]-iodo-5-hydroxy-N,N-dimethyltryptamine (2-[131 I]-iodo-bufotenine), and 2-[131I]-iodo-tryptamine and the known 2-[131I]-iodo-N-acetyl-5-methoxy-tryptamine (2-[131I]-iodo-melatonine) are described herein. These were synthesized by a high-yield novel method, and their spectral properties are fully described. These compounds are of biological importance and can be used for brain mapping with SPECT technology.
Registro:
| Documento: | Artículo |
| Título: | Synthesis of 131I derivatives of indolealkylamines for brain mapping |
| Autor: | Sintas, J.A.; Vitale, A.A. |
| Filiación: | Depto. de Quim. Orgánica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, 1428 Buenos Aires, Argentina |
| Palabras clave: | 2-[131I]-iodo-5-hydroxy-N,N-dimethyltryptamine; 2-[131I]-iodo-5-methoxy-N,N-dimethyltryptamine; 2-[131I]-iodo-N,N-dimethyltryptamine; 2-[131I]-iodo-N-methyltryptamine; 2-[131I]-iodo-tryptamine; 2-[131I]-melatonine; indoleamine; iodine 131; tryptamine derivative; article; brain mapping; drug purity; drug synthesis; in vitro study; iodination; mass spectrometry; nuclear magnetic resonance spectroscopy; radiochemistry; radioiodination; reaction analysis |
| Año: | 1997 |
| Volumen: | 39 |
| Número: | 8 |
| Página de inicio: | 677 |
| Página de fin: | 684 |
| DOI: | http://dx.doi.org/10.1002/(SICI)1099-1344(199708)39:8<677::AID-JLCR9>3.0.CO;2-G |
| Título revista: | Journal of Labelled Compounds and Radiopharmaceuticals |
| Título revista abreviado: | J. LABEL. COMPD. RADIOPHARM. |
| ISSN: | 03624803 |
| CODEN: | JLCRD |
| CAS: | indoleamine, 56480-48-9; iodine 131, 10043-66-0, 15124-39-7; tryptamine derivative, 1019-45-0 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03624803_v39_n8_p677_Sintas |
Referencias:
- Angrist, S., Gershon, G., Sathananthan, R., Walker, B., (1976) Psychopharmacol., 47, p. 29
- Bidder, T.G., Mandel, L.R., Ahn, H.S., (1974) Lancet., 1, p. 165
- Heller, B., Narasimhachari, J., Spaide, J., (1970) Experientia., 26, p. 503
- Lipinski, J.F., Mandel, L.R., Ahn, H.S., (1974) Biol. Psychiatry, 9, p. 89
- Narasimhachari, N., Heller, B., Spaide, (1971) J. Biol. Psychiatry, 3, p. 21
- Wyatt, R.J., Mandel, R.L., Ahn, H.W., (1973) Psychopharmacol., 31, p. 265
- Checkley, S.A., Oon, M.C., Rodnight, R., (1979) Amer. J. Psychiatry, 136, p. 439
- Oon, M.C., Rodnight, R., (1977) Biochem. Med., 18, p. 410
- Raisanen, M., Karkkainen, J., (1979) J. Chromatogr., 162, p. 579
- Rodnight, R., Murray, M.C., Oon, M.C., Brockintogton, I.F., (1976) Psychol. Med., 6, p. 649
- Christian, S.T., Benington, F., Morin, R.D., (1975) Biochem. Med., 14, p. 191
- Dewhurst, W.G., (1968) Nature, 218, p. 1130
- Corbett, L., Christian, S.T., Morin, R.D., Brit, (1978) J. Psychiatry, 132, p. 139
- Stromberg, V.L., (1954) J. Amer. Chem. Soc., 76, p. 1707
- Harley-Mason, J., Jackson, A.H., (1954) J. Amer. Chem. Soc., 76, p. 1165
- Speeter, M.E., William, C.A., (1954) J. Amer. Chem. Soc., 76, p. 6208
- Benington, F., Morin, R.D., Clark, L.C., (1958) J. Org. Chem., 23, p. 1977
- Noland, W.E., Hartman, P.J., (1954) J. Amer. Chem. Soc., 76, p. 3227
- Noland, W.E., Lange, R.F., (1959) J. Amer. Chem. Soc., 81, p. 1203
- Noland, W.E., Lange, R.F., (1959) J. Org. Chem., 24, p. 894
- Vitali, T., Mossini, F., (1959) Bull. Sci. Fac. Chim. Ind. Bologna, 17, p. 84
- Robinson, B., (1982) The Fischer Indole Synthesis, , John Wiley and Sons: New York
- Chen, C.-Y., Senanayake, C.H., Bill, J.T., (1994) J. Org. Chem., 59, p. 3738
- Morris, E.F., Cheng Chiao, J., (1993) J. Label. Comp. Radiopharm., 33, p. 455
- Kline, T., (1985) J. Heterocycl. Chem., 22, p. 505
- McKillop, A., Hunt, J.D., Zelesko, M.J., Fowler, J.S., (1971) J. Amer. Chem. Soc., 93, p. 4841
Citas:
---------- APA ----------
Sintas, J.A. & Vitale, A.A. (1997) . Synthesis of 131I derivatives of indolealkylamines for brain mapping. Journal of Labelled Compounds and Radiopharmaceuticals, 39(8), 677-684.http://dx.doi.org/10.1002/(SICI)1099-1344(199708)39:8<677::AID-JLCR9>3.0.CO;2-G
---------- CHICAGO ----------
Sintas, J.A., Vitale, A.A. "Synthesis of 131I derivatives of indolealkylamines for brain mapping" . Journal of Labelled Compounds and Radiopharmaceuticals 39, no. 8 (1997) : 677-684.http://dx.doi.org/10.1002/(SICI)1099-1344(199708)39:8<677::AID-JLCR9>3.0.CO;2-G
---------- MLA ----------
Sintas, J.A., Vitale, A.A. "Synthesis of 131I derivatives of indolealkylamines for brain mapping" . Journal of Labelled Compounds and Radiopharmaceuticals, vol. 39, no. 8, 1997, pp. 677-684.http://dx.doi.org/10.1002/(SICI)1099-1344(199708)39:8<677::AID-JLCR9>3.0.CO;2-G
---------- VANCOUVER ----------
Sintas, J.A., Vitale, A.A. Synthesis of 131I derivatives of indolealkylamines for brain mapping. J. LABEL. COMPD. RADIOPHARM. 1997;39(8):677-684.http://dx.doi.org/10.1002/(SICI)1099-1344(199708)39:8<677::AID-JLCR9>3.0.CO;2-G
