Abstract:
Biological and chemical characteristics of 99mTc‐phenethylamines complexes are presented. 2‐(4,5‐Dimethoxy‐2‐nitrophenyl)ethylamine, 2‐(3,4‐dimethoxyphenyl)ethylamine and 2‐(2‐amino‐4,5‐dimethoxyphenyl)‐ethylamine were used as ligands. A preliminary evaluation of these 99mTc‐complexes as dopamine receptor radioligands was also performed. Net charges at each atom were also calculated by a semiempirical ZINDO/1 method for comparison of free ligands' parameters with those of the respective technetium‐complexes. Copyright © 1995 John Wiley & Sons, Ltd.
Registro:
Documento: |
Artículo
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Título: | Preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes |
Autor: | Vitale, A.A.; Calvino, M.A.; Ferrari, C.C.; Stahl, A.E.; Pomilio, A.B. |
Filiación: | CONICET, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, Buenos Aires, 1428, Argentina Ineuci-Conicet, Departamento de Ciencias Biológicas, Fcen, Uba, Argentina
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Palabras clave: | 2‐(2‐Amino‐4,5‐dimethoxyphenyl)ethylamine; 2‐(3,4‐Dimethoxyphenyl)‐ethylamine; 2‐(4,5‐Dimethoxy‐2‐nitrophenyl)ethylamine; 99m‐Technetium complexes; Biodistribution; Preparation; semiempirical ZINDO/1 calculations; phenethylamine derivative; technetium 99m; technetium complex; animal experiment; article; brain; controlled study; drug distribution; drug structure; drug synthesis; electrophoresis; female; intracerebral drug administration; isotope labeling; nonhuman; radiochromatography; rat; Animalia |
Año: | 1995
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Volumen: | 36
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Número: | 6
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Página de inicio: | 509
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Página de fin: | 519
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DOI: |
http://dx.doi.org/10.1002/jlcr.2580360602 |
Título revista: | Journal of Labelled Compounds and Radiopharmaceuticals
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Título revista abreviado: | J. Label. Compd. Radiopharm.
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ISSN: | 03624803
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03624803_v36_n6_p509_Vitale |
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Citas:
---------- APA ----------
Vitale, A.A., Calvino, M.A., Ferrari, C.C., Stahl, A.E. & Pomilio, A.B.
(1995)
. Preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes. Journal of Labelled Compounds and Radiopharmaceuticals, 36(6), 509-519.
http://dx.doi.org/10.1002/jlcr.2580360602---------- CHICAGO ----------
Vitale, A.A., Calvino, M.A., Ferrari, C.C., Stahl, A.E., Pomilio, A.B.
"Preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes"
. Journal of Labelled Compounds and Radiopharmaceuticals 36, no. 6
(1995) : 509-519.
http://dx.doi.org/10.1002/jlcr.2580360602---------- MLA ----------
Vitale, A.A., Calvino, M.A., Ferrari, C.C., Stahl, A.E., Pomilio, A.B.
"Preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes"
. Journal of Labelled Compounds and Radiopharmaceuticals, vol. 36, no. 6, 1995, pp. 509-519.
http://dx.doi.org/10.1002/jlcr.2580360602---------- VANCOUVER ----------
Vitale, A.A., Calvino, M.A., Ferrari, C.C., Stahl, A.E., Pomilio, A.B. Preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes. J. Label. Compd. Radiopharm. 1995;36(6):509-519.
http://dx.doi.org/10.1002/jlcr.2580360602