Artículo
Caballero, G.M.; Gros, E.G. "Synthesis of [20,21‐13C2]‐pregnenolone" (1993) Journal of Labelled Compounds and Radiopharmaceuticals. 33(10):907-911
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Abstract:
The synthesis of [20,21‐13C2]‐pregnenolone (7) from androst‐5‐en‐3β‐ol‐17‐one (1) is described. Labelled carbons were introduced by two procedures, namely, condensation of 1 with K13CN and Grignard reaction of nitrile derivative 5 with [13C]‐methylmagnesium iodide. Location of labels was confirmed by 13C‐NMR spectroscopy. Copyright © 1993 John Wiley & Sons, Ltd.
Registro:
| Documento: | Artículo |
| Título: | Synthesis of [20,21‐13C2]‐pregnenolone |
| Autor: | Caballero, G.M.; Gros, E.G. |
| Filiación: | Departamento de Química Orgánica, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, 1428, Argentina |
| Palabras clave: | synthesis; [20,21‐13C2]‐pregnenolone; carbon 13; pregnenolone; article; controlled study; drug synthesis; isotope labeling |
| Año: | 1993 |
| Volumen: | 33 |
| Número: | 10 |
| Página de inicio: | 907 |
| Página de fin: | 911 |
| DOI: | http://dx.doi.org/10.1002/jlcr.2580331004 |
| Título revista: | Journal of Labelled Compounds and Radiopharmaceuticals |
| Título revista abreviado: | J. Label. Compd. Radiopharm. |
| ISSN: | 03624803 |
| CAS: | carbon 13, 14762-74-4; pregnenolone, 145-13-1 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03624803_v33_n10_p907_Caballero |
Referencias:
- Leete, E., Gregory, H., Gros, E.G., (1965) J. Am. Chem. Soc., 87, p. 3475
- Tschesche, R., Becker, R., Hombach, R., (1968) Z. Naturforsch., 23 b, p. 1615
- Maier, M.S., Seldes, A.M., Gros, E.G., (1986) Phytochemistry, 25, p. 1327
- Deluca, M.E., Seldes, A.M., Gros, E.G., (1989) Phytochemistry, 28, p. 109
- Caballero, G.M., Gros, E.G., (1991) J. Lab. Compds. Radiopharm., 29, p. 805
- Hosoda, H., Fukushima, D.K., Fishman, J., (1973) J. Org. Chem., 38, p. 4209
- Corey, E.J., Venkateswarlu, A., (1972) J. Am. Chem. Soc., 94, p. 6190
Citas:
---------- APA ----------
Caballero, G.M. & Gros, E.G. (1993) . Synthesis of [20,21‐13C2]‐pregnenolone. Journal of Labelled Compounds and Radiopharmaceuticals, 33(10), 907-911.http://dx.doi.org/10.1002/jlcr.2580331004
---------- CHICAGO ----------
Caballero, G.M., Gros, E.G. "Synthesis of [20,21‐13C2]‐pregnenolone" . Journal of Labelled Compounds and Radiopharmaceuticals 33, no. 10 (1993) : 907-911.http://dx.doi.org/10.1002/jlcr.2580331004
---------- MLA ----------
Caballero, G.M., Gros, E.G. "Synthesis of [20,21‐13C2]‐pregnenolone" . Journal of Labelled Compounds and Radiopharmaceuticals, vol. 33, no. 10, 1993, pp. 907-911.http://dx.doi.org/10.1002/jlcr.2580331004
---------- VANCOUVER ----------
Caballero, G.M., Gros, E.G. Synthesis of [20,21‐13C2]‐pregnenolone. J. Label. Compd. Radiopharm. 1993;33(10):907-911.http://dx.doi.org/10.1002/jlcr.2580331004
