Artículo
Maier, M.S.; Seldes, A.M.; Gros, E.G. "Synthesis of |24‐14C|‐23‐norcholanoic acid derivatives" (1985) Journal of Labelled Compounds and Radiopharmaceuticals. 22(5):467-474
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Abstract:
Syntheses of |24‐14C| 3β, 20ξ‐dihydroxy‐23‐norchol‐5‐enoic acid, |24‐14C| 3β, 20ξ‐dihydroxy‐23‐norcholanoic acid and |24‐14C| 20ξ‐hydroxy‐3‐oxo‐23‐norchol‐4‐enoic acid were accomplished by reaction of ethyl |1‐14C| bromoacetate, in Reformatsky conditions, with suitable 20‐keto‐pregnane derivatives. Dehydration of these products afforded |24‐14C| 3β‐hydroxy‐23‐norchola‐5, 20(22)E‐enoic acid and |24‐14C| 3‐oxo‐23‐norchola‐4, 20(22)E‐dienoic acid respectively. The products were characterized by spectroscopic (IR, 1H NMR, MS) methods. Copyright © 1985 John Wiley & Sons, Ltd.
Registro:
| Documento: | Artículo |
| Título: | Synthesis of |24‐14C|‐23‐norcholanoic acid derivatives |
| Autor: | Maier, M.S.; Seldes, A.M.; Gros, E.G. |
| Filiación: | Departamento de Quimica Orgànica Y Umymfor, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, Buenos Aires, 1428, Argentina |
| Palabras clave: | Ethyl |1‐14C| bromoacetate; Reformatsky reaction; Synthesis; |24‐14C|‐23‐Norcholanic acid derivatives; radioisotope; 20 hydroxy 3 oxo 23 norchol 4 enoic acid c 14; 3 oxo 23 norchola 4,20(22) dienoic acid c 14; 3beta hydroxy 23 norchol 20(22) enoic acid c 14; 3beta hydroxy 23 norchola 5,20(22) dienoic acid c 14; 3beta,20 dihydroxy 23 norchol 5 enoic acid c 14; 3beta,20 dihydroxy 23 norcholanic acid c 14; drug analysis; drug identification; drug synthesis; infrared spectrometry; mass spectrometry; nonhuman; nuclear magnetic resonance; priority journal; theoretical study |
| Año: | 1985 |
| Volumen: | 22 |
| Número: | 5 |
| Página de inicio: | 467 |
| Página de fin: | 474 |
| DOI: | http://dx.doi.org/10.1002/jlcr.2580220508 |
| Título revista: | Journal of Labelled Compounds and Radiopharmaceuticals |
| Título revista abreviado: | J. Label. Compd. Radiopharm. |
| ISSN: | 03624803 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03624803_v22_n5_p467_Maier |
Referencias:
- Galagovsky, L.R., Porto, A.M., Burton, G., Gros, E.G., (1984) Z. Naturforsch., 39 c, p. 38. , and previous papers cited therein
- Galagovsky, L.R., Porto, A.M., Burton, G., Maier, M.S., Seldes, A.M., Gros, E.G., (1982) An. Asoc. Quim. Argent., 70, p. 327
- Ruzicka, L., Reichstein, T., Furst, A., (1941) Helvetica Chimica Acta, 24, p. 76
- Colonna, A.O., Gros, E.G., (1973) J. Steroid Biochem., 4, p. 171
- Burton, G., Gros, E.G., (1977) J. Steroid Biochem., 8, p. 69
- Burton, G., Gros, E.G., (1977) J. Lab. Compds. Radiopharm., 13, p. 627
- Seldes, A.M., Anding, C.A., Gros, E.G., (1982) Steroids, 36, p. 575
- Seldes, A.M., Gros, E.G., (1982) Steroids, 39, p. 181
- Mousseron‐Canet, M., Beziat, I., (1968), p. 2572. , Bull. Soc. Chim. Fr; Ruzicka, L., Plattner, P.A., Patki, J., (1942) Helv. Chim. Acta, 25, p. 425
Citas:
---------- APA ----------
Maier, M.S., Seldes, A.M. & Gros, E.G. (1985) . Synthesis of |24‐14C|‐23‐norcholanoic acid derivatives. Journal of Labelled Compounds and Radiopharmaceuticals, 22(5), 467-474.http://dx.doi.org/10.1002/jlcr.2580220508
---------- CHICAGO ----------
Maier, M.S., Seldes, A.M., Gros, E.G. "Synthesis of |24‐14C|‐23‐norcholanoic acid derivatives" . Journal of Labelled Compounds and Radiopharmaceuticals 22, no. 5 (1985) : 467-474.http://dx.doi.org/10.1002/jlcr.2580220508
---------- MLA ----------
Maier, M.S., Seldes, A.M., Gros, E.G. "Synthesis of |24‐14C|‐23‐norcholanoic acid derivatives" . Journal of Labelled Compounds and Radiopharmaceuticals, vol. 22, no. 5, 1985, pp. 467-474.http://dx.doi.org/10.1002/jlcr.2580220508
---------- VANCOUVER ----------
Maier, M.S., Seldes, A.M., Gros, E.G. Synthesis of |24‐14C|‐23‐norcholanoic acid derivatives. J. Label. Compd. Radiopharm. 1985;22(5):467-474.http://dx.doi.org/10.1002/jlcr.2580220508
