Artículo

Rela, L.; Yang, S.M.; Szczupak, L. "Calcium spikes in a leech nonspiking neuron" (2009) Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 195(2):139-150
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Abstract:

The NS neurons are nonspiking cells, present as pairs in each midbody ganglion of the leech nervous system, which display a very extensive arborization. They were shown to regulate the coactivation of motoneurons. Here we have investigated the electrophysiological properties of these neurons under the hypothesis that transmission along the extensive neurites requires the aid of voltage-dependent conductances. The results indicate that NS neurons respond to electrical stimulation with a spike-like event, which was not an all-or-none but rather a graded phenomenon that depended on the intensity and duration of the electrical stimulus. The spike-like response was activated at a membrane potential of approximately -50 mV; its amplitude was a logarithmic function of the extracellular Ca 2+ concentration and was unaffected by a broad range of changes in the extracellular Na + concentration; intracellular application of tetraethylammonium (TEA) caused a large increase in its amplitude and duration. These data indicate that NS neurons bear voltage-dependent low-threshold Ca 2+ and TEA-sensitive K + conductances that could contribute to shaping synaptic signals, or transmission along the extensive neuritic tree. © 2008 Springer-Verlag.

Registro:

Documento: Artículo
Título:Calcium spikes in a leech nonspiking neuron
Autor:Rela, L.; Yang, S.M.; Szczupak, L.
Filiación:Dpto. de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón II, piso 2, Buenos Aires 1428, Argentina
Department of Neurosurgery, Yale University School of Medicine, PO Box 208082, New Haven, CT 06520, United States
Palabras clave:Calcium spikes; Low threshold voltage-dependent calcium conductance; N-methyl-d-glucamine; Nonspiking neuron; Postinhibitory rebound; calcium; potassium; animal; article; cell membrane potential; leech; metabolism; nerve cell; nerve conduction; patch clamp; physiology; Animals; Calcium; Leeches; Membrane Potentials; Neural Conduction; Neurons; Patch-Clamp Techniques; Potassium
Año:2009
Volumen:195
Número:2
Página de inicio:139
Página de fin:150
DOI: http://dx.doi.org/10.1007/s00359-008-0393-4
Título revista:Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology
Título revista abreviado:J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol.
ISSN:03407594
CODEN:JCPAD
CAS:calcium, 7440-70-2; potassium, 7440-09-7; Calcium, 7440-70-2; Potassium, 7440-09-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03407594_v195_n2_p139_Rela

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Citas:

---------- APA ----------
Rela, L., Yang, S.M. & Szczupak, L. (2009) . Calcium spikes in a leech nonspiking neuron. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, 195(2), 139-150.
http://dx.doi.org/10.1007/s00359-008-0393-4
---------- CHICAGO ----------
Rela, L., Yang, S.M., Szczupak, L. "Calcium spikes in a leech nonspiking neuron" . Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology 195, no. 2 (2009) : 139-150.
http://dx.doi.org/10.1007/s00359-008-0393-4
---------- MLA ----------
Rela, L., Yang, S.M., Szczupak, L. "Calcium spikes in a leech nonspiking neuron" . Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, vol. 195, no. 2, 2009, pp. 139-150.
http://dx.doi.org/10.1007/s00359-008-0393-4
---------- VANCOUVER ----------
Rela, L., Yang, S.M., Szczupak, L. Calcium spikes in a leech nonspiking neuron. J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 2009;195(2):139-150.
http://dx.doi.org/10.1007/s00359-008-0393-4