Artículo

Zacarías Fluck, M.F.; Hess, L.; Salatino, M.; Croci, D.O.; Stupirski, J.C.; Di Masso, R.J.; Roggero, E.; Rabinovich, G.A.; Scharovsky, O.G. "The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide" (2012) Cancer Immunology, Immunotherapy. 61(4):469-480
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Abstract:

Although lymphomas account for almost half of blood-derived cancers that are diagnosed each year, the causes of new cases are poorly understood, as reflected by the relatively few risk factors established. Galectin-1, an immunoregulatory β-galactoside-binding protein, has been widely associated with tumor-immune escape. The aim of the present work was to study the relationship between tumor growth rate, aggressiveness, and response to cyclophosphamide (Cy) therapy with regard to Gal-1 expression in murine T-cell lymphoma models. By means of a disruptive selection process for tumor growth rate, we generated two lymphoma variants from a parental T-cell lymphoma, which have unique characteristics in terms of tumor growth rate, spontaneous regression, metastatic capacity, Gal-1 expression and sensitivity to Cy therapy. Here, we show that Gal-1 expression strongly correlates with tumor growth rate, metastatic capacity and response to singledose Cy therapy in T-cell lymphoma models; this association might have important consequences for evaluating prognosis and treatments of this type of tumors. © Springer-Verlag 2011.

Registro:

Documento: Artículo
Título:The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide
Autor:Zacarías Fluck, M.F.; Hess, L.; Salatino, M.; Croci, D.O.; Stupirski, J.C.; Di Masso, R.J.; Roggero, E.; Rabinovich, G.A.; Scharovsky, O.G.
Filiación:Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario (UNR), Santa Fe 3100, S2002KTR Rosario, Argentina
Preclinical Research Program, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain
Laboratorio de Inmunopatología, Instituto de Biología Y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas Y Técnicas (CONICET), Vuelta de Obligado 2490, C1428 Ciudad de Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina
Palabras clave:Aggressiveness; Cyclophosphamide; Galectin-1; Lymphoma; cyclophosphamide; galectin 1; animal experiment; animal model; animal tissue; article; cancer chemotherapy; cancer growth; cancer regression; controlled study; correlation analysis; disease activity; female; growth rate; in vivo study; metastasis potential; mouse; nonhuman; outcome assessment; priority journal; protein expression; single drug dose; T cell lymphoma; treatment response; Animals; Antigens, CD4; Cell Proliferation; Cyclophosphamide; Female; Forkhead Transcription Factors; Galectin 1; Gene Expression Regulation, Neoplastic; Humans; Immunosuppression; Interleukin-2 Receptor alpha Subunit; Lymphoma, T-Cell; Mice; Neoplasm Metastasis; T-Lymphocytes, Regulatory
Año:2012
Volumen:61
Número:4
Página de inicio:469
Página de fin:480
DOI: http://dx.doi.org/10.1007/s00262-011-1114-3
Título revista:Cancer Immunology, Immunotherapy
Título revista abreviado:Cancer Immunol. Immunother.
ISSN:03407004
CODEN:CIIMD
CAS:cyclophosphamide, 50-18-0; galectin 1, 258495-34-0; Antigens, CD4; Cyclophosphamide, 50-18-0; Forkhead Transcription Factors; Foxp3 protein, mouse; Galectin 1; Interleukin-2 Receptor alpha Subunit
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03407004_v61_n4_p469_ZacariasFluck

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Citas:

---------- APA ----------
Zacarías Fluck, M.F., Hess, L., Salatino, M., Croci, D.O., Stupirski, J.C., Di Masso, R.J., Roggero, E.,..., Scharovsky, O.G. (2012) . The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide. Cancer Immunology, Immunotherapy, 61(4), 469-480.
http://dx.doi.org/10.1007/s00262-011-1114-3
---------- CHICAGO ----------
Zacarías Fluck, M.F., Hess, L., Salatino, M., Croci, D.O., Stupirski, J.C., Di Masso, R.J., et al. "The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide" . Cancer Immunology, Immunotherapy 61, no. 4 (2012) : 469-480.
http://dx.doi.org/10.1007/s00262-011-1114-3
---------- MLA ----------
Zacarías Fluck, M.F., Hess, L., Salatino, M., Croci, D.O., Stupirski, J.C., Di Masso, R.J., et al. "The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide" . Cancer Immunology, Immunotherapy, vol. 61, no. 4, 2012, pp. 469-480.
http://dx.doi.org/10.1007/s00262-011-1114-3
---------- VANCOUVER ----------
Zacarías Fluck, M.F., Hess, L., Salatino, M., Croci, D.O., Stupirski, J.C., Di Masso, R.J., et al. The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide. Cancer Immunol. Immunother. 2012;61(4):469-480.
http://dx.doi.org/10.1007/s00262-011-1114-3