Abstract:
Background: Previously we observed in some but not all septic patients a low plasma concentration of plasminogen. Objectives: To investigate prospectively whether plasma levels of plasminogen or the ratio of plasminogen to alpha-2-antiplasmin have a prognostic value for survival from sepsis and to study the variation of other hemostatic parameters during septicemia. Patients: The study population consisted of 45 consecutive patients with septicemia, 15 non-septic patients from the same intensive care unit and 30 healthy volunteers. Measurements and Main Results: Plasminogen concentrations were significantly lower (p < 0.001) in plasma of septic patients (median 0,62 IU/ml range: 0.15-1,06) than in plasma of healthy controls (median 1.00 IU/ml, range: 0.75-1.10) or of non-septic intensive care patients (median 1.00 IU/ml, range: 0.82-1.08). Among the other parameters tested, plasminogen activator inhibitor (PAI-1) antigen concentration and PAI activity were similar in septic and non-septic intensive care patients, but higher than in healthy controls. Concentrations of elastase-alpha-1-protease inhibitor or of thrombin-antithrombin complexes were higher in septic patients than in non-septic intensive care patients or healthy controls. A degraded form of plasminogen of 38 kDa was detected by Western blot analysis in the plasma of septic patients, but not in plasma of non-septic intensive care patients or controls. Plasminogen alone or the ratio of plasminogen to antiplasmin were good markers for survival from septicemia. E.g. for plasminogen at a cut off of 0.65 IU/ml, sensitivity was 90.5% and specificity 66.7%, whereas for the ratio of plasminogen over antiplasmin at a cut off ratio of 0,65 IU/ml, sensitivity was 95.2% and specificity 70.8%. Conclusion: Plasminogen or the ratio of plasminogen to antiplasmin are sensitive markers for survival in patients with septicemia.
Registro:
Documento: |
Artículo
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Título: | Plasminogen: An important hemostatic parameter in septic patients |
Autor: | Duboscq, C.; Quintana, I.; Bassilotta, E.; Bergonzelli, G.E.; Porterie, P.; Sassetti, B.; Haedo, A.S.; Wainsztein, N.; Kruithof, E.K.O.; Kordich, L. |
Filiación: | Dpto. de Quim. Biológica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina Gastroenterology Division, University Hospital, Lausanne, Switzerland Department of Critical Care, Hospital Privado Güemes, Buenos Aires, Argentina Division of Angiology and Hemostasis, University Hospital, Geneva, Switzerland
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Palabras clave: | alpha 2 antiplasmin; antiplasmin; antithrombin; elastase alpha 1 protease inhibitor; elastase inhibitor; plasminogen; plasminogen activator inhibitor; thrombin; unclassified drug; adult; aged; article; blood clotting; controlled study; enzyme activity; fibrinolysis; hemostasis; human; immunoblotting; intensive care; major clinical study; priority journal; prognosis; protein blood level; protein degradation; sepsis; septicemia; Adult; Aged; Antiplasmin; Hemostasis; Humans; Middle Aged; Plasminogen; Prognosis; Prospective Studies; Sepsis |
Año: | 1997
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Volumen: | 77
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Número: | 6
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Página de inicio: | 1090
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Página de fin: | 1095
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Título revista: | Thrombosis and Haemostasis
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Título revista abreviado: | THROMB. HAEMOST.
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ISSN: | 03406245
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CODEN: | THHAD
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CAS: | Antiplasmin; Plasminogen, 9001-91-6
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03406245_v77_n6_p1090_Duboscq |
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Citas:
---------- APA ----------
Duboscq, C., Quintana, I., Bassilotta, E., Bergonzelli, G.E., Porterie, P., Sassetti, B., Haedo, A.S.,..., Kordich, L.
(1997)
. Plasminogen: An important hemostatic parameter in septic patients. Thrombosis and Haemostasis, 77(6), 1090-1095.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03406245_v77_n6_p1090_Duboscq [ ]
---------- CHICAGO ----------
Duboscq, C., Quintana, I., Bassilotta, E., Bergonzelli, G.E., Porterie, P., Sassetti, B., et al.
"Plasminogen: An important hemostatic parameter in septic patients"
. Thrombosis and Haemostasis 77, no. 6
(1997) : 1090-1095.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03406245_v77_n6_p1090_Duboscq [ ]
---------- MLA ----------
Duboscq, C., Quintana, I., Bassilotta, E., Bergonzelli, G.E., Porterie, P., Sassetti, B., et al.
"Plasminogen: An important hemostatic parameter in septic patients"
. Thrombosis and Haemostasis, vol. 77, no. 6, 1997, pp. 1090-1095.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03406245_v77_n6_p1090_Duboscq [ ]
---------- VANCOUVER ----------
Duboscq, C., Quintana, I., Bassilotta, E., Bergonzelli, G.E., Porterie, P., Sassetti, B., et al. Plasminogen: An important hemostatic parameter in septic patients. THROMB. HAEMOST. 1997;77(6):1090-1095.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03406245_v77_n6_p1090_Duboscq [ ]