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Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-β on the activity of two important metalloproteinases (MMP-2 and MMP-9) that are involved in extracellular matrix remodeling as well as the secretion of leptin, one of the reproductive hormones actively regulating their activity and secretion. We found that IL-1β activates matrix metalloproteinase activity as well as increases leptin secretion. We propose that this interleukin, through the regulation of leptin, in turn activates matrix metalloproteinases which results in an increased cytotrophoblast invasion.


Documento: Artículo
Título:Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model
Autor:Fontana, V.A.; Sanchez, M.; Cebral, E.; Calvo, J.C.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Laboratorio de Biología del Desarrollo, Instituto de Fisiología, Biología Molecular y Neurociencias, DBBE, Facultad de Ciencias Exactas y Naturales, Universidad de, Buenos Aires, Argentina
Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
Palabras clave:Cytokines; Embryo implantation; Extracellular matrix; Placenta; gelatinase A; gelatinase B; interleukin 1beta; leptin; gelatinase A; gelatinase B; interleukin 1beta; leptin; MMP2 protein, human; article; cell invasion; controlled study; cytotrophoblast; enzyme activity; extracellular matrix; hormone release; human; human cell; regulatory mechanism; biological model; cell line; drug effect; enzymology; female; metabolism; nidation; physiology; pregnancy; secretion; trophoblast; Cell Line; Embryo Implantation; Female; Humans; Interleukin-1beta; Leptin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Models, Biological; Pregnancy; Trophoblasts
Página de inicio:37
Página de fin:43
Título revista:Biocell
Título revista abreviado:Biocell
CAS:gelatinase A, 146480-35-5; gelatinase B, 146480-36-6; Interleukin-1beta; Leptin; MMP2 protein, human,; Matrix Metalloproteinase 2,; Matrix Metalloproteinase 9,


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---------- APA ----------
Fontana, V.A., Sanchez, M., Cebral, E. & Calvo, J.C. (2010) . Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model. Biocell, 34(1), 37-43.
Recuperado de [ ]
---------- CHICAGO ----------
Fontana, V.A., Sanchez, M., Cebral, E., Calvo, J.C. "Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model" . Biocell 34, no. 1 (2010) : 37-43.
Recuperado de [ ]
---------- MLA ----------
Fontana, V.A., Sanchez, M., Cebral, E., Calvo, J.C. "Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model" . Biocell, vol. 34, no. 1, 2010, pp. 37-43.
Recuperado de [ ]
---------- VANCOUVER ----------
Fontana, V.A., Sanchez, M., Cebral, E., Calvo, J.C. Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model. Biocell. 2010;34(1):37-43.
Available from: [ ]