Artículo
Abstract:
Chronic administration of Hexachlorobenzene, with or without the simultaneous administration of Tioctamide was assayed. Hexachlorobenzene alone produced the characteristic porphyria, detected through an increase of the urinary excretion and the hepatic accumulation of porphyrins, as well as by a decrease of the Uroporphyrinogen decarboxylase activity. The content of hepatic conjugated dienes did not change while those of malondialdehyde increased, although without reaching levels of statistical significance. These results would indicate the occurrence of an light lipid peroxidation process. The Thioctamide (25 mg/kg body weight) produced more noxious effects than protective ones, which were detected by a high level of Glutamate piruvate transaminase activity and a decrease of the hepatic Uroporphyrinogen decarboxylase activity, at its first step of decarboxylation. These results might indicate that: 1) high doses of Thioctamide decreases Uroporphyrinogen decarboxylase activity, masking its possible protective effect from Hexachlorobenzene's action through free radicals production and, 2) Uroporphyrinogen decarboxylase is a more sensitive parameter than conjugated dienes or malondialdehyde levels to assay the free radicals in vivo Hexachlorobenzene production. In any case, the Thioctamide assayed in lower and non toxic doses, perhaps might protect against Hexachlorobenzene's action through its free radical scavenger ability.
Registro:
| Documento: | Artículo |
| Título: | Effect of thioctamide against the action of hexachlorobenzene |
| Autor: | Vilas, G.L.; Ureta, D.; Sanches Garcia, M.C.; Aldonatti, C.; San Martin de Viale, L.C.; Rios de Molina, M.C. |
| Filiación: | Dpto. de Quimica Biologica, Facultad Ciencias Exactas/Naturales, Universiad de Buenos Aires, Ciudad Universitaria, (1428) Buenos Aires, Argentina |
| Palabras clave: | Heme metabolic pathway; Hexaclorobenzene; Lipidic peroxidation; Porphyrias; Thioctamide; alanine aminotransferase; alkadiene; amide; free radical; hexachlorobenzene; malonaldehyde; porphyrin; thioctamide; thioctic acid; unclassified drug; uroporphyrinogen decarboxylase; article; controlled study; enzyme activity; lipid peroxidation; nonhuman; porphyria; rat; scavenging system; 5-Aminolevulinate Synthetase; Alanine Transaminase; Amides; Animals; Free Radicals; Fungicides, Industrial; Hexachlorobenzene; Lipid Peroxidation; Liver; Porphobilinogen; Porphyrins; Rats; Rats, Wistar; Thioctic Acid; Time Factors; Uroporphyrinogen Decarboxylase |
| Año: | 1998 |
| Volumen: | 48 |
| Número: | 3 |
| Página de inicio: | 137 |
| Página de fin: | 145 |
| Título revista: | Acta Physiologica Pharmacologica et Therapeutica Latinoamericana |
| Título revista abreviado: | Acta Physiol. Pharmacol. Ther. Latinoam. |
| ISSN: | 03276309 |
| CODEN: | APTLE |
| CAS: | 5-Aminolevulinate Synthetase, EC 2.3.1.37; Alanine Transaminase, EC 2.6.1.2; Amides; Free Radicals; Fungicides, Industrial; Hexachlorobenzene, 118-74-1; Porphobilinogen, 487-90-1; Porphyrins; Thioctic Acid, 62-46-4; Uroporphyrinogen Decarboxylase, EC 4.1.1.37 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v48_n3_p137_Vilas |
Citas:
---------- APA ----------
Vilas, G.L., Ureta, D., Sanches Garcia, M.C., Aldonatti, C., San Martin de Viale, L.C. & Rios de Molina, M.C. (1998) . Effect of thioctamide against the action of hexachlorobenzene . Acta Physiologica Pharmacologica et Therapeutica Latinoamericana, 48(3), 137-145.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v48_n3_p137_Vilas [ ]
---------- CHICAGO ----------
Vilas, G.L., Ureta, D., Sanches Garcia, M.C., Aldonatti, C., San Martin de Viale, L.C., Rios de Molina, M.C. "Effect of thioctamide against the action of hexachlorobenzene " . Acta Physiologica Pharmacologica et Therapeutica Latinoamericana 48, no. 3 (1998) : 137-145.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v48_n3_p137_Vilas [ ]
---------- MLA ----------
Vilas, G.L., Ureta, D., Sanches Garcia, M.C., Aldonatti, C., San Martin de Viale, L.C., Rios de Molina, M.C. "Effect of thioctamide against the action of hexachlorobenzene " . Acta Physiologica Pharmacologica et Therapeutica Latinoamericana, vol. 48, no. 3, 1998, pp. 137-145.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v48_n3_p137_Vilas [ ]
---------- VANCOUVER ----------
Vilas, G.L., Ureta, D., Sanches Garcia, M.C., Aldonatti, C., San Martin de Viale, L.C., Rios de Molina, M.C. Effect of thioctamide against the action of hexachlorobenzene . Acta Physiol. Pharmacol. Ther. Latinoam. 1998;48(3):137-145.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v48_n3_p137_Vilas [ ]
