Artículo
Abstract:
Repeated isolation stress and prazosin effect were evaluated in 7,12-dimethylbenz[A]anthracene (DMBA) mammary tumors. Tumor volume was significantly lower in stressed than in control animals from 10 to 52 days considering day 1 the moment when tumors became palpable and treatment began. Control Prazosin (0.5 mg/kg) rats showed diminished tumor volume after 40 days. Stress Prazosin curve was similar to stress alone. The proportion of progressing tumors in control was significantly higher than in stressed groups, regardles of Prazosin administration. Body weight gain was similar in every group throughout the experiment. Behavioral studies were performed when stress effect was no longer evident. Grooming and the number of fecal boli were similar in all groups, as well as prolactin serum levels, suggesting that habituation took place. No significant differences were observed between groups for estrogen receptors. However, a greater concentration of progesterone receptors was found in stressed rats, compared to all other groups. We conclude that the decrease of tumor volume provoked by stress could not be reversed by the α1-adrenergic antagonist prazosin. Then, it appears that the main effect of stress is not mediated by the α1-adrenergic receptors. Higher progesterone receptors in stressed rats could explain the differences observed.
Registro:
| Documento: | Artículo |
| Título: | Prazosin and stress effect on tumoral growth of 7,12-dimethylbenz[A]anthracene-induced rat mammary tumors |
| Autor: | Wendel, V.; Maris Vazquez, S.; Durante, P.C.; Lemoine, A.P.; Segura, E.T.; Calandra, R.S.; Luthy, I.A. |
| Filiación: | Instituto de Biologia/Med. Experim., Consejo Nac. Invest. Cient./Tecnicas, Obligado 2490, 1428 Buenos Aires, Argentina |
| Palabras clave: | a-adrenergic receptors; mammary cancer; prazosin; stress; 7,12 dimethylbenz[a]anthracene; alpha 1 adrenergic receptor; estrogen receptor; gestagen receptor; prazosin; unclassified drug; animal experiment; animal model; article; breast cancer; controlled study; drug effect; female; nonhuman; rat; stress; tumor growth; 9,10-Dimethyl-1,2-benzanthracene; Adrenergic alpha-Antagonists; Animals; Female; Mammary Neoplasms, Experimental; Prazosin; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Receptors, Progesterone; Stress |
| Año: | 1996 |
| Volumen: | 46 |
| Número: | 4 |
| Página de inicio: | 277 |
| Página de fin: | 285 |
| Título revista: | Acta Physiologica Pharmacologica et Therapeutica Latinoamericana |
| Título revista abreviado: | ACTA PHYSIOL. PHARMACOL. THER. LATINOAM. |
| ISSN: | 03276309 |
| CODEN: | APTLE |
| CAS: | 9,10-Dimethyl-1,2-benzanthracene, 57-97-6; Adrenergic alpha-Antagonists; Prazosin, 19216-56-9; Prolactin, 9002-62-4; Receptors, Estrogen; Receptors, Progesterone |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v46_n4_p277_Wendel |
Citas:
---------- APA ----------
Wendel, V., Maris Vazquez, S., Durante, P.C., Lemoine, A.P., Segura, E.T., Calandra, R.S. & Luthy, I.A. (1996) . Prazosin and stress effect on tumoral growth of 7,12-dimethylbenz[A]anthracene-induced rat mammary tumors. Acta Physiologica Pharmacologica et Therapeutica Latinoamericana, 46(4), 277-285.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v46_n4_p277_Wendel [ ]
---------- CHICAGO ----------
Wendel, V., Maris Vazquez, S., Durante, P.C., Lemoine, A.P., Segura, E.T., Calandra, R.S., et al. "Prazosin and stress effect on tumoral growth of 7,12-dimethylbenz[A]anthracene-induced rat mammary tumors" . Acta Physiologica Pharmacologica et Therapeutica Latinoamericana 46, no. 4 (1996) : 277-285.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v46_n4_p277_Wendel [ ]
---------- MLA ----------
Wendel, V., Maris Vazquez, S., Durante, P.C., Lemoine, A.P., Segura, E.T., Calandra, R.S., et al. "Prazosin and stress effect on tumoral growth of 7,12-dimethylbenz[A]anthracene-induced rat mammary tumors" . Acta Physiologica Pharmacologica et Therapeutica Latinoamericana, vol. 46, no. 4, 1996, pp. 277-285.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v46_n4_p277_Wendel [ ]
---------- VANCOUVER ----------
Wendel, V., Maris Vazquez, S., Durante, P.C., Lemoine, A.P., Segura, E.T., Calandra, R.S., et al. Prazosin and stress effect on tumoral growth of 7,12-dimethylbenz[A]anthracene-induced rat mammary tumors. ACTA PHYSIOL. PHARMACOL. THER. LATINOAM. 1996;46(4):277-285.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v46_n4_p277_Wendel [ ]
