Artículo
Abstract:
Urinary parameters related to acid-base homeostasis were studied in adrenalectomized rats (ADX) as well as in ADX treated with physiological doses of corticosterone (B), aldosterone (aldo) or 18-Hydroxycorticosterone (18HOB) during 1, 3 or 5 days, under basal conditions and after gravage with 200 mM HCl. The results showed: a) a persistent effect of B and 18HOB increasing titratable acidity principally in response to acidosis; b) an increased phosphate elimination in acidotic B treated ADX on the first day, and in 18HOB treated ADX on days 3 and 5; c) pronounced increases in blood pH and blood bicarbonate levels provoked by the three steroids on day 1; d) increments of ammonium elimination in response to acidosis by aldo treatment on the first day, while B and 18HOB increase ammonium elimination under almost all conditions during the whole experiment; e) the effects of B and 18HOB would be independent of an increase in sodium retention as well as glomerular filtration rate.
Registro:
| Documento: | Artículo |
| Título: | Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat |
| Autor: | Igarreta, M.P.; Lantos, C.P.; Damasco, M.C. |
| Filiación: | Depto. de Quimica Biologica, Fac. de Ciencias Exactas y Naturales, UBA, 1428 Buenos Aires, Argentina |
| Palabras clave: | 18 hydroxycorticosterone; acid-base regulation; aldosterone; corticosterone; metabolic acidosis; 18 hydroxycorticosterone; aldosterone; ammonia; corticosterone; phosphate; acid base balance; animal experiment; article; controlled study; drug effect; excretion; glomerulus filtration; intramuscular drug administration; male; metabolic acidosis; nonhuman; rat; Acid-Base Equilibrium; Aldosterone; Animals; Corticosterone; Kidney; Male; Rats; Rats, Sprague-Dawley |
| Año: | 1996 |
| Volumen: | 46 |
| Número: | 3 |
| Página de inicio: | 149 |
| Página de fin: | 158 |
| Título revista: | Acta Physiologica Pharmacologica et Therapeutica Latinoamericana |
| Título revista abreviado: | ACTA PHYSIOL. PHARMACOL. THER. LATINOAM. |
| ISSN: | 03276309 |
| CODEN: | APTLE |
| CAS: | Aldosterone, 52-39-1; Corticosterone, 50-22-6 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v46_n3_p149_Igarreta |
Citas:
---------- APA ----------
Igarreta, M.P., Lantos, C.P. & Damasco, M.C. (1996) . Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat. Acta Physiologica Pharmacologica et Therapeutica Latinoamericana, 46(3), 149-158.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v46_n3_p149_Igarreta [ ]
---------- CHICAGO ----------
Igarreta, M.P., Lantos, C.P., Damasco, M.C. "Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat" . Acta Physiologica Pharmacologica et Therapeutica Latinoamericana 46, no. 3 (1996) : 149-158.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v46_n3_p149_Igarreta [ ]
---------- MLA ----------
Igarreta, M.P., Lantos, C.P., Damasco, M.C. "Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat" . Acta Physiologica Pharmacologica et Therapeutica Latinoamericana, vol. 46, no. 3, 1996, pp. 149-158.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v46_n3_p149_Igarreta [ ]
---------- VANCOUVER ----------
Igarreta, M.P., Lantos, C.P., Damasco, M.C. Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat. ACTA PHYSIOL. PHARMACOL. THER. LATINOAM. 1996;46(3):149-158.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v46_n3_p149_Igarreta [ ]
