Artículo
De Calmanovici, R.W.; Cochon, A.C.; Aldonatti, C.A.; Cabral, J.R.P.; San Martin De Viale, L.C. "Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine" (1995) Acta Physiologica Pharmacologica et Therapeutica Latinoamericana. 45(1):49-52
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Abstract:
Uroporphyrinogen I Synthase (URO-S) activity was measured in erythrocytes of female and male rats which had received diethylnitrosamine (DENA) as an inducer of hepatic tumors. Twenty-two weeks after the last dose of the carcinogen, the rats showed statistically significant increases in the URO-S activity. Differences in the body weight, erythrocyte porphyrin content or the hematocrit between treated and control rats were not found. Fifty percent of female rats and thirty percent of male rats treated with DENA were found to have hepatic tumors but there was no correlation between blood URO-S-activity and tumoral development in spite of the increase in UROS-S activity observed in DENA treated rats. This was observed both in male and female rats.
Registro:
| Documento: | Artículo |
| Título: | Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine |
| Autor: | De Calmanovici, R.W.; Cochon, A.C.; Aldonatti, C.A.; Cabral, J.R.P.; San Martin De Viale, L.C. |
| Filiación: | Lab. Porfirias Exp./Metabolismo Hemo, Departamento de Quimica Biologica, Universidad de Buenos Aires, Nunez, Buenos Aires 1428, Argentina |
| Palabras clave: | diethylnitrosamine; hepatic tumors; porphyrins; rats; uroporphyrinogen I synthase; diethylnitrosamine; porphobilinogen deaminase; porphyrin; animal cell; animal experiment; animal model; article; controlled study; enzyme activity; erythrocyte; female; liver tumor; male; nonhuman; rat; Animal; Carcinoma, Hepatocellular; Diethylnitrosamine; Erythrocytes; Female; Hydroxymethylbilane Synthase; Liver Neoplasms; Male; Rats; Support, Non-U.S. Gov't |
| Año: | 1995 |
| Volumen: | 45 |
| Número: | 1 |
| Página de inicio: | 49 |
| Página de fin: | 52 |
| Título revista: | Acta Physiologica Pharmacologica et Therapeutica Latinoamericana |
| Título revista abreviado: | ACTA PHYSIOL. PHARMACOL. THER. LATINOAM. |
| ISSN: | 03276309 |
| CODEN: | APTLE |
| CAS: | diethylnitrosamine, 55-18-5; porphobilinogen deaminase, 9036-47-9, 9074-91-3; porphyrin, 24869-67-8; Diethylnitrosamine, 55-18-5; Hydroxymethylbilane Synthase, EC 4.3.1.8 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v45_n1_p49_DeCalmanovici |
Citas:
---------- APA ----------
De Calmanovici, R.W., Cochon, A.C., Aldonatti, C.A., Cabral, J.R.P. & San Martin De Viale, L.C. (1995) . Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine. Acta Physiologica Pharmacologica et Therapeutica Latinoamericana, 45(1), 49-52.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v45_n1_p49_DeCalmanovici [ ]
---------- CHICAGO ----------
De Calmanovici, R.W., Cochon, A.C., Aldonatti, C.A., Cabral, J.R.P., San Martin De Viale, L.C. "Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine" . Acta Physiologica Pharmacologica et Therapeutica Latinoamericana 45, no. 1 (1995) : 49-52.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v45_n1_p49_DeCalmanovici [ ]
---------- MLA ----------
De Calmanovici, R.W., Cochon, A.C., Aldonatti, C.A., Cabral, J.R.P., San Martin De Viale, L.C. "Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine" . Acta Physiologica Pharmacologica et Therapeutica Latinoamericana, vol. 45, no. 1, 1995, pp. 49-52.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v45_n1_p49_DeCalmanovici [ ]
---------- VANCOUVER ----------
De Calmanovici, R.W., Cochon, A.C., Aldonatti, C.A., Cabral, J.R.P., San Martin De Viale, L.C. Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine. ACTA PHYSIOL. PHARMACOL. THER. LATINOAM. 1995;45(1):49-52.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v45_n1_p49_DeCalmanovici [ ]
