Artículo

Pavan, M.E.; Pettinari, M.J.; Cairó, F.; Pavan, E.E.; Cataldi, A.A. "Bacillus anthracis: A molecular look at a famous pathogen " (2011) Revista Argentina de Microbiologia. 43(4):294-310
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Abstract:

Bacillus anthracis, a gram-positive rod belonging to the Bacillus cereus group, has an extremely monomorphic genome, and presents high structural and physiological similarity with B. cereus and Bacillus thuringiensis. In this work, the new molecular methods for the identification and typing of B. anthracis developed in the last years, based on variable number tandem repeats or on genetic differences detected through sequencing, are described. The molecular aspects of traditional virulence factors: capsule, protective antigen, lethal factor and edema factor are described in depth, together with virulence factors recently proposed, such as the siderophores petrobactin and bacillibactin, the S-layer adhesin and the MntA lipoprotein. It is detailed the molecular organization of megaplasmids pXO1 and pXO2, including the pathogenicity island of pXO1. The genetic skeleton of these plasmids has been observed in related species, and this could be attributed to lateral gene transfer. Finally, the two anthrax toxin protective antigen receptors, ANTXR1/TEM8 and ANTXR2/CMG2, essential for the interaction of the pathogen with the host, are presented. The molecular studies performed in recent years have greatly increased knowledge in different aspects of this microorganism and its relationship with the host, but at the same time they have raised new questions about this noted pathogen.

Registro:

Documento: Artículo
Título:Bacillus anthracis: A molecular look at a famous pathogen
Autor:Pavan, M.E.; Pettinari, M.J.; Cairó, F.; Pavan, E.E.; Cataldi, A.A.
Filiación:Biochemiq S.A., Laboratorio de Biología Molecular, Ingeniero Butty 240, 4to piso, (C1001AFB), CABA, Italy
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, CABA, Argentina
Laboratorio di Tecnologie Biomediche, Dipartimento di Bioingegneria, Politecnico di Milano, Italy
Instituto de Biotecnología, CNIA-INTA. Castelar, CC77 (1708) Buenos Aires, Argentina
Palabras clave:Anthrax; Bacillus anthracis; Genetic diversity; Megaplasmids; Molecular aspects; Virulence factors; adhesin; bacillibactin; bacterial antigen; bacterium edema factor; lipoprotein; petrobactin; protein MntA; siderophore; unclassified drug; virulence factor; article; Bacillus anthracis; bacterial membrane; bacterial virulence; bacterium identification; host pathogen interaction; lethal gene; nonhuman; pathogenicity island; plasmid; species; tandem repeat; Animals; Anthrax; Antigens, Bacterial; Bacillus; Bacillus anthracis; Bacterial Capsules; Bacterial Toxins; Bacterial Typing Techniques; Base Sequence; DNA, Bacterial; Genomic Islands; Humans; Membrane Proteins; Minisatellite Repeats; Molecular Sequence Data; Neoplasm Proteins; Plasmids; Polymorphism, Single Nucleotide; Receptors, Cell Surface; Sequence Alignment; Sequence Homology, Nucleic Acid; Virulence; Zoonoses
Año:2011
Volumen:43
Número:4
Página de inicio:294
Página de fin:310
Título revista:Revista Argentina de Microbiologia
Título revista abreviado:Rev. Argent. Microbiol.
ISSN:03257541
CODEN:RAMID
CAS:ANTXR1 protein, human; ANTXR2 protein, human; Antigens, Bacterial; Bacterial Capsules; Bacterial Toxins; DNA, Bacterial; Membrane Proteins; Neoplasm Proteins; Receptors, Cell Surface; anthrax toxin
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v43_n4_p294_Pavan

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Citas:

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Pavan, M.E., Pettinari, M.J., Cairó, F., Pavan, E.E. & Cataldi, A.A. (2011) . Bacillus anthracis: A molecular look at a famous pathogen . Revista Argentina de Microbiologia, 43(4), 294-310.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v43_n4_p294_Pavan [ ]
---------- CHICAGO ----------
Pavan, M.E., Pettinari, M.J., Cairó, F., Pavan, E.E., Cataldi, A.A. "Bacillus anthracis: A molecular look at a famous pathogen " . Revista Argentina de Microbiologia 43, no. 4 (2011) : 294-310.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v43_n4_p294_Pavan [ ]
---------- MLA ----------
Pavan, M.E., Pettinari, M.J., Cairó, F., Pavan, E.E., Cataldi, A.A. "Bacillus anthracis: A molecular look at a famous pathogen " . Revista Argentina de Microbiologia, vol. 43, no. 4, 2011, pp. 294-310.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v43_n4_p294_Pavan [ ]
---------- VANCOUVER ----------
Pavan, M.E., Pettinari, M.J., Cairó, F., Pavan, E.E., Cataldi, A.A. Bacillus anthracis: A molecular look at a famous pathogen . Rev. Argent. Microbiol. 2011;43(4):294-310.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v43_n4_p294_Pavan [ ]