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Different immunomodulatory activities present in Trichilia glabra (TG) leaf extracts have already been described. Particularly, chloroform-methanol extracts were responsible for an in-vivo anti-inflammatory effect. The effect of such extracts on the infectivity of enveloped and naked viruses were investigated. Methanolic fraction extracts were active against herpes simplex virus type 1 (HSV-1) and vesicular stomatitis virus (VSV), while no activity against poliovirus type 3 was observed. VSV was slightly more affected than HSV-1: 2.8 log10 reduction in VSV titer against 2.4 log10 reduction in HSV-1 titer when 0.25 mg/ml F2 fraction was tested and a reduction of 2.7 log10 in VSV virus titer and of 1.5 log10 in HSV-1 virus titer was observed when 0.25 mg/ml F3 fraction was tested. Results obtained in this work suggest a potential pharmaceutical use of TG extract components.


Documento: Artículo
Título:Virucidal activity presence in Trichilia glabra leaves
Autor:Cella, M.; Riva, D.A.; Coulombié, F.C.; Mersich, S.E.
Filiación:CEFYBO, Serrano 669, 1414, Buenos Aires, Argentina
Dto. Química Biológica, FCEyN, UBA, Pab2 P4, 1428, Buenos Aires, Argentina
Palabras clave:Methanolic extracts; Trichilia glabra leaves; Virucidal activity; chloroform; methanol; plant extract; Trichilia glabra extract; unclassified drug; antiinflammatory activity; antiviral activity; article; controlled study; Herpes simplex virus 1; immunomodulation; in vivo study; medicinal plant; nonhuman; plant leaf; Poliomyelitis virus; Trichilia glabra; Vesicular stomatitis virus; virus infectivity; virus titration; Animals; Antiviral Agents; Cercopithecus aethiops; Chemical Fractionation; Chloroform; Herpesvirus 1, Human; Meliaceae; Methanol; Plant Extracts; Plant Leaves; Poliovirus; Vero Cells; Vesicular stomatitis-Indiana virus
Página de inicio:136
Página de fin:138
Título revista:Revista Argentina de Microbiologia
Título revista abreviado:Rev. Argent. Microbiol.
CAS:chloroform, 67-66-3; methanol, 67-56-1; Antiviral Agents; Chloroform, 67-66-3; Methanol, 67-56-1; Plant Extracts


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---------- APA ----------
Cella, M., Riva, D.A., Coulombié, F.C. & Mersich, S.E. (2004) . Virucidal activity presence in Trichilia glabra leaves. Revista Argentina de Microbiologia, 36(3), 136-138.
Recuperado de [ ]
---------- CHICAGO ----------
Cella, M., Riva, D.A., Coulombié, F.C., Mersich, S.E. "Virucidal activity presence in Trichilia glabra leaves" . Revista Argentina de Microbiologia 36, no. 3 (2004) : 136-138.
Recuperado de [ ]
---------- MLA ----------
Cella, M., Riva, D.A., Coulombié, F.C., Mersich, S.E. "Virucidal activity presence in Trichilia glabra leaves" . Revista Argentina de Microbiologia, vol. 36, no. 3, 2004, pp. 136-138.
Recuperado de [ ]
---------- VANCOUVER ----------
Cella, M., Riva, D.A., Coulombié, F.C., Mersich, S.E. Virucidal activity presence in Trichilia glabra leaves. Rev. Argent. Microbiol. 2004;36(3):136-138.
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