Artículo
Barquero, A.A.; Villamil, S.M. "Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model " (1997) Revista Argentina de microbiología. 29(1):32-37
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Abstract:
We evaluated the in vitro antiviral activity of meliacin combined with foscarnet on the herpes simplex type 1 (HSV-1) strains F and B2006 (tk-) replication. The effective concentrations for 50% inhibition of HSV-1 (F) were 12.5 micrograms/ml for meliacin and 15.7 micrograms/ml for foscarnet, while for HSV-1 (B2006) were 3.1 micrograms/ml and 126 micrograms/ml, respectively. The data were analyzed for quantitation of synergism, additivity, and antagonism of multiple drug effect by the three-dimensional model. Some of the meliacin -foscarnet combinations synergistically inhibited HSV-1 (F) and HSV-1 (B2006) replication in vitro at concentrations that did not reduce cellular viability.
Registro:
| Documento: | Artículo |
| Título: | Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model |
| Autor: | Barquero, A.A.; Villamil, S.M. |
| Filiación: | Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina |
| Palabras clave: | antivirus agent; foscarnet; meliacin; peptide; vegetable protein; animal; antibiotic resistance; article; cell survival; Cercopithecus; classification; comparative study; drug effect; drug potentiation; Herpes simplex virus; physiology; species difference; Vero cell; virus replication; Animals; Antiviral Agents; Cell Survival; Cercopithecus aethiops; Drug Resistance, Microbial; Drug Synergism; Foscarnet; Peptides; Plant Proteins; Simplexvirus; Species Specificity; Vero Cells; Virus Replication |
| Año: | 1997 |
| Volumen: | 29 |
| Número: | 1 |
| Página de inicio: | 32 |
| Página de fin: | 37 |
| Título revista: | Revista Argentina de microbiología |
| Título revista abreviado: | Rev. Argent. Microbiol. |
| ISSN: | 03257541 |
| CAS: | foscarnet, 4428-95-9; Antiviral Agents; Foscarnet, 4428-95-9; meliacin; Peptides; Plant Proteins |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v29_n1_p32_Barquero |
Citas:
---------- APA ----------
Barquero, A.A. & Villamil, S.M. (1997) . Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model . Revista Argentina de microbiología, 29(1), 32-37.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v29_n1_p32_Barquero [ ]
---------- CHICAGO ----------
Barquero, A.A., Villamil, S.M. "Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model " . Revista Argentina de microbiología 29, no. 1 (1997) : 32-37.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v29_n1_p32_Barquero [ ]
---------- MLA ----------
Barquero, A.A., Villamil, S.M. "Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model " . Revista Argentina de microbiología, vol. 29, no. 1, 1997, pp. 32-37.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v29_n1_p32_Barquero [ ]
---------- VANCOUVER ----------
Barquero, A.A., Villamil, S.M. Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model . Rev. Argent. Microbiol. 1997;29(1):32-37.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v29_n1_p32_Barquero [ ]
