Artículo
Castilla, V.; Mersich, S.E.; Damonte, E.B. "Lysosomotropic compounds inhibiting the multiplication of Junin virus " (1991) Revista Argentina de microbiología. 23(2):86-89
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Abstract:
A number of lysosomotropic compounds of diverse chemical structure, ammonium chloride, procaine and chlorpheniramine, were found to inhibit the infection of Vero cells by Junín virus. Viral replication was almost totally inhibited by 15 mM ammonium chloride, when added either before or within the first hour of infection and a significant inhibition (97.8%) was observed when it was added 8 hours after infection. These results agree with a model which postulates that arenavirus entry occurs by receptor-mediated endocytosis.
Registro:
| Documento: | Artículo |
| Título: | Lysosomotropic compounds inhibiting the multiplication of Junin virus |
| Autor: | Castilla, V.; Mersich, S.E.; Damonte, E.B. |
| Filiación: | Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina |
| Palabras clave: | ammonium chloride; chlorpheniramine; procaine; virus receptor; animal; Arenavirus; article; chemical phenomena; comparative study; drug effect; endocytosis; lysosome; physiology; Vero cell; virus replication; Ammonium Chloride; Animals; Arenaviruses, New World; Chlorpheniramine; Depression, Chemical; Endocytosis; Lysosomes; Procaine; Receptors, Virus; Vero Cells; Virus Replication |
| Año: | 1991 |
| Volumen: | 23 |
| Número: | 2 |
| Página de inicio: | 86 |
| Página de fin: | 89 |
| Título revista: | Revista Argentina de microbiología |
| Título revista abreviado: | Rev. Argent. Microbiol. |
| ISSN: | 03257541 |
| CAS: | ammonium chloride, 12125-02-9; chlorpheniramine, 132-22-9; procaine, 51-05-8, 59-46-1; Ammonium Chloride, 12125-02-9, 59-46-1; Chlorpheniramine, 132-22-9, 59-46-1; Procaine, 59-46-1; Receptors, Virus |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v23_n2_p86_Castilla |
Citas:
---------- APA ----------
Castilla, V., Mersich, S.E. & Damonte, E.B. (1991) . Lysosomotropic compounds inhibiting the multiplication of Junin virus . Revista Argentina de microbiología, 23(2), 86-89.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v23_n2_p86_Castilla [ ]
---------- CHICAGO ----------
Castilla, V., Mersich, S.E., Damonte, E.B. "Lysosomotropic compounds inhibiting the multiplication of Junin virus " . Revista Argentina de microbiología 23, no. 2 (1991) : 86-89.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v23_n2_p86_Castilla [ ]
---------- MLA ----------
Castilla, V., Mersich, S.E., Damonte, E.B. "Lysosomotropic compounds inhibiting the multiplication of Junin virus " . Revista Argentina de microbiología, vol. 23, no. 2, 1991, pp. 86-89.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v23_n2_p86_Castilla [ ]
---------- VANCOUVER ----------
Castilla, V., Mersich, S.E., Damonte, E.B. Lysosomotropic compounds inhibiting the multiplication of Junin virus . Rev. Argent. Microbiol. 1991;23(2):86-89.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v23_n2_p86_Castilla [ ]
