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Abstract:

Erythropoietin (Epo), the cytokine required for promoting erythropoiesis through the proliferation and differentiation of erythroid cells, has been reported to act as a pleiotropic cytokine beyond the hematopoietic system. In contrast with the potentially beneficial effects attributed to recombinant human erythropoietin (rhuEpo), research has advanced to indicate that mor tality and morbidity rates are increased in some patient groups when treated with rhuEpo. Some cardiac and systemic conditions may predispose to adverse events, and other factors, such as proinflammatory agents, may lead to resistance to erythropoietin treatment. Many compounds are currently under investigation in order to avoid these unwanted effects and to reduce the rhuEpo dose during chronic therapies. They are either erythropoiesis-stimulating agents different from erythropoietin or structurally modified erythropoietins with altered properties and activities. In recent reports, contrasting data have raised several concerns regarding the effectiveness of erythropoietin treatment to prevent adverse events. Therefore, much investigation is needed to provide a solid basis for the development of conclusive clinical trials.

Registro:

Documento: Artículo
Título:Erythropoietic and non-erythropoietic functions of erythropoietin: Therapeutic considerations
Autor:Vittori, D.; Chamorro, M.E.; Nesse, A.
Filiación:Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto Del Departamento de Quimica Biologica de la Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Pabellon II, Piso 4, Ciudad Autonoma de Buenos aires, Argentina
Palabras clave:Adverse effects; Carbamylated erythropoietin; Erythropoietic stimulating factors; Erythropoietin; Resistance to erythropoietin; Signalling pathways
Año:2016
Volumen:50
Número:4
Página de inicio:773
Página de fin:782
Título revista:Acta Bioquimica Clinica Latinoamericana
Título revista abreviado:Acta Bioquim. Clin. Latinoam.
ISSN:03252957
CODEN:ABCLD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n4_p773_Vittori

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Citas:

---------- APA ----------
Vittori, D., Chamorro, M.E. & Nesse, A. (2016) . Erythropoietic and non-erythropoietic functions of erythropoietin: Therapeutic considerations . Acta Bioquimica Clinica Latinoamericana, 50(4), 773-782.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n4_p773_Vittori [ ]
---------- CHICAGO ----------
Vittori, D., Chamorro, M.E., Nesse, A. "Erythropoietic and non-erythropoietic functions of erythropoietin: Therapeutic considerations " . Acta Bioquimica Clinica Latinoamericana 50, no. 4 (2016) : 773-782.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n4_p773_Vittori [ ]
---------- MLA ----------
Vittori, D., Chamorro, M.E., Nesse, A. "Erythropoietic and non-erythropoietic functions of erythropoietin: Therapeutic considerations " . Acta Bioquimica Clinica Latinoamericana, vol. 50, no. 4, 2016, pp. 773-782.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n4_p773_Vittori [ ]
---------- VANCOUVER ----------
Vittori, D., Chamorro, M.E., Nesse, A. Erythropoietic and non-erythropoietic functions of erythropoietin: Therapeutic considerations . Acta Bioquim. Clin. Latinoam. 2016;50(4):773-782.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n4_p773_Vittori [ ]