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Abstract:

Increased plasma homocysteine levels (hyperhomocysteinemia) are associated with occlusive vascular diseases, such as atherosclerosis and thrombosis. Reduced homocysteine (Hcy) and its cyclic ester, homocysteine thiolactone (HTL) would be involved in the detrimental effects associated to hyperhomocysteinemia. These two species, Hcy and HTL can spontaneously react with proteins, through S and N-homocysteinylation process, respectively. Both reactions produce post-translational protein changes, impairing structural and functional features. In recent years, interest has been developed in HTL and its effects on human health. N-homocysteinylation is the reaction between the carboxyl group of HTL and ϵ-amino group of lysine residues, rendering free sulfhydryl groups able to participate in redox reactions. N-homocysteinylated proteins are prone to misfolding and oxidative damage, inducing cytotoxic and immunogenic effects. Metabolic conversion of Hcy to HTL as well as protein N-homocysteinylation is one of the mechanisms underlying the development of pathologies associated to hyperhomocysteinemia, such as cardiovascular and neurodegenerative diseases.

Registro:

Documento: Artículo
Título:N-homocysteinylation reactions related to hyperhomocysteinemia
Autor:Genoud, V.; Quintana, I.
Filiación:Laboratorio de Hemostasia y Trombosis, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Int. Güiraldes 2160, Pabellón II, Ciudad Autónoma De Buenos Aires, C1428EGA, Argentina
Palabras clave:Homocysteine-thiolactone; Hyperhomocysteinemia; N-homocysteinylation; Occlusive vascular disease
Año:2016
Volumen:50
Número:4
Página de inicio:679
Página de fin:685
Título revista:Acta Bioquimica Clinica Latinoamericana
Título revista abreviado:Acta Bioquim. Clin. Latinoam.
ISSN:03252957
CODEN:ABCLD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n4_p679_Genoud

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Citas:

---------- APA ----------
Genoud, V. & Quintana, I. (2016) . N-homocysteinylation reactions related to hyperhomocysteinemia . Acta Bioquimica Clinica Latinoamericana, 50(4), 679-685.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n4_p679_Genoud [ ]
---------- CHICAGO ----------
Genoud, V., Quintana, I. "N-homocysteinylation reactions related to hyperhomocysteinemia " . Acta Bioquimica Clinica Latinoamericana 50, no. 4 (2016) : 679-685.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n4_p679_Genoud [ ]
---------- MLA ----------
Genoud, V., Quintana, I. "N-homocysteinylation reactions related to hyperhomocysteinemia " . Acta Bioquimica Clinica Latinoamericana, vol. 50, no. 4, 2016, pp. 679-685.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n4_p679_Genoud [ ]
---------- VANCOUVER ----------
Genoud, V., Quintana, I. N-homocysteinylation reactions related to hyperhomocysteinemia . Acta Bioquim. Clin. Latinoam. 2016;50(4):679-685.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n4_p679_Genoud [ ]