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Abstract:

Perhaps for being considered mere megakaryocyte cytoplasmic debris responsible for wound repair alone, platelets have had a secondary role when compared to other cellular blood components. However, in the last 20 years we have learned much more about these fascinating cells, which have slowly regained a prominent place in hematology. This review discusses the most outstanding and novel contributions on platelet biogenesis, its regulation by the bone marrow microenvironment and humoral factors, analyzing from megakaryocyte generation to platelet release.

Registro:

Documento: Artículo
Título:The birth of a platelet: A trip from bone marrow megakaryocytes to circulating platelets
Autor:Rivadeneyra, L.; Ivani, P.C.; Schattner, M.; Pozner, R.G.
Filiación:Laboratorio de Trombosis Experimental, Instituto de Medicina Experimental (IMEX), CONICET Academia Nacional de Medicina, Ciudad Autónoma de Buenos Aires, Pacheco de Melo 3081, Argentina
Depto. de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Palabras clave:Chemokines; Cytokines; Hematopoiesis; Hemostasis; Megakaryocytes; Megakaryopoiesis; Platelet biogenesis; Platelets; Thrombopoiesis; Thrombosis
Año:2016
Volumen:50
Número:2
Página de inicio:233
Página de fin:245
Título revista:Acta Bioquimica Clinica Latinoamericana
Título revista abreviado:Acta Bioquim. Clin. Latinoam.
ISSN:03252957
CODEN:ABCLD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n2_p233_Rivadeneyra

Referencias:

  • Ribatti, D., Crivellato, E., Giulio Bizzozero and the discovery of platelets (2007) Leuk Res, 31 (10), pp. 1339-1341. , Oct
  • Wagner, D.D., New links between inflammation and thrombosis (2005) Arterioscler Thromb Vasc Biol, 25 (7), pp. 1321-1324. , Jul
  • Yeaman, M.R., Platelets: At the nexus of antimicrobial defence (2014) Nat Rev Microbiol, 12 (6), pp. 426-437. , Jun
  • Semple, J.W., Italiano, J.E., Jr., Freedman, J., Platelets and the immune continuum (2011) Nat Rev Immunol, 11 (4), pp. 264-274. , Apr
  • Brass, L.F., Did dinosaurs have megakaryocytes? New ideas about platelets and their progenitors (2005) J Clin Invest, 115 (12), pp. 3329-3331. , Dec
  • Long, M.W., Williams, N., Ebbe, S., Immature megakaryocytes in the mouse: Physical characteristics, cell cycle status, and in vitro responsiveness to thrombopoietic stimulatory factor (1982) Blood, 59 (3), pp. 569-575. , Mar
  • Michelson, A.D., (2013) Platelets, , 3rd. ed. Oxford, United Kingdom: Elsevier
  • Geddis, A.E., Fox, N.E., Tkachenko, E., Kaushansky, K., Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression (2007) Cell Cycle, 6 (4), pp. 455-460. , Feb 15
  • Lordier, L., Jalil, A., Aurade, F., Larbret, F., Larghero, J., Debili, N., Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling (2008) Blood, 112 (8), pp. 3164-3174. , Oct 15
  • Odell, T.T., Jr., Jackson, C.W., Friday, T.J., Megakaryocytopoiesis in rats with special reference to polyploidy (1970) Blood, 35 (6), pp. 775-782. , Jun
  • Zimmet, J., Ravid, K., Polyploidy: Occurrence in nature, mechanisms, and significance for the megakaryocyteplatelet system (2000) Exp Hematol, 28 (1), pp. 3-16. , Jan
  • Raslova, H., Roy, L., Vourc'h, C., Le Couedic, J.P., Brison, O., Metivier, D., Megakaryocyte polyploidization is associated with a functional gene amplification (2003) Blood, 101 (2), pp. 541-544. , Jan 15
  • Trakala, M., Rodriguez-Acebes, S., Maroto, M., Symonds, C.E., Santamaria, D., Ortega, S., Functional reprogramming of polyploidization in megakaryocytes (2015) Dev Cell, 32 (2), pp. 155-167. , Jan 26
  • Kautz, J., De Marsh, Q.B., Electron microscopy of sectioned blood and bone marrow elements (1955) Rev Hematol, 10 (2), pp. 314-323. , discussion, 24-44
  • Kostyak, J.C., Naik, U.P., Megakaryopoiesis: Transcriptional insights into megakaryocyte maturation (2007) Front Biosci, 12, pp. 2050-2062
  • Schulze, H., Korpal, M., Hurov, J., Kim, S.W., Zhang, J., Cantley, L.C., Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis (2006) Blood, 107 (10), pp. 3868-3875. , May 15
  • Gerrard, J.M., White, J.G., Rao, G.H., Townsend, D., Localization of platelet prostaglandin production in the platelet dense tubular system (1976) Am J Pathol, 83 (2), pp. 283-298. , May
  • Thon, J.N., Italiano, J.E., Platelets: Production, morphology and ultrastructure (2012) Handb Exp Pharmacol, (210), pp. 3-22
  • Van Nispen, T.P.H., De Haas, F., Geerts, W., Posthuma, G., Van Dijk, S., Heijnen, H.F., The platelet interior revisited: Electron tomography reveals tubular alpha-granule subtypes (2010) Blood, 116 (7), pp. 1147-1156. , Aug 19
  • Kamykowski, J., Carlton, P., Sehgal, S., Storrie, B., Quantitative immunofluorescence mapping reveals little functional coclustering of proteins within platelet alpha-granules (2011) Blood, 118 (5), pp. 1370-1373. , Aug 4
  • Jones, O.P., Origin of megakaryocyte granules from Golgi vesicles (1960) Anat Rec, 138, pp. 105-113. , Oct
  • Handagama, P.J., George, J.N., Shuman, M.A., McEver, R.P., Bainton, D.F., Incorporation of a circulating protein into megakaryocyte and platelet granules (1987) Proc Natl Acad Sci U S A, 84 (3), pp. 861-865. , Feb
  • Youssefian, T., Cramer, E.M., Megakaryocyte dense granule components are sorted in multivesicular bodies (2000) Blood, 95 (12), pp. 4004-4007. , Jun 15
  • Meyers, K.M., Holmsen, H., Seachord, C.L., Comparative study of platelet dense granule constituents (1982) Am J Physiol, 243 (3), pp. R454-R461. , Sep
  • Wright, J., The origin and nature of blood platelets (1906) Boston Med Surg J, 154, pp. 643-645
  • Djaldetti, M., Fishman, P., Bessler, H., Notti, I., SEM observations on the mechanism of platelet release from megakaryocytes (1979) Thromb Haemost, 42 (2), pp. 611-620. , Aug 31
  • Ihzumi, T., Hattori, A., Sanada, M., Muto, M., Megakaryocyte and platelet formation: A scanning electron microscope study in mouse spleen (1977) Arch Histol Jpn, 40 (4), pp. 305-320. , Sep
  • Shaklai, M., Tavassoli, M., Demarcation membrane system in rat megakaryocyte and the mechanism of platelet formation: A membrane reorganization process (1978) J Ultrastruct Res, 62 (3), pp. 270-285. , Mar
  • Italiano, J.E., Jr., Lecine, P., Shivdasani, R.A., Hartwig, J.H., Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes (1999) J Cell Biol, 147 (6), pp. 1299-1312. , Dec 13
  • Thon, J.N., Montalvo, A., Patel-Hett, S., Devine, M.T., Richardson, J.L., Ehrlicher, A., Cytoskeletal mechanics of proplatelet maturation and platelet release (2010) J Cell Biol, 191 (4), pp. 861-874. , Nov 15
  • Behnke, O., An electron microscope study of the rat megacaryocyte. II. Some aspects of platelet release and microtubules (1969) J Ultrastruct Res, 26 (1), pp. 111-129. , Jan
  • Becker, R.P., De Bruyn, P.P., The transmural passage of blood cells into myeloid sinusoids and the entry of platelets into the sinusoidal circulation; A scanning electron microscopic investigation (1976) Am J Anat, 145 (2), pp. 183-205. , Feb
  • Patel, S.R., Hartwig, J.H., Italiano, J.E., Jr., The biogenesis of platelets from megakaryocyte proplatelets (2005) J Clin Invest, 115 (12), pp. 3348-3354. , Dec
  • Choi, E.S., Nichol, J.L., Hokom, M.M., Hornkohl, A.C., Hunt, P., Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional (1995) Blood, 85 (2), pp. 402-413. , Jan 15
  • Miyazaki, R., Ogata, H., Iguchi, T., Sogo, S., Kushida, T., Ito, T., Comparative analyses of megakaryocytes derived from cord blood and bone marrow (2000) Br J Haematol, 108 (3), pp. 602-609. , Mar
  • Pozner, R.G., Negrotto, S., D'Atri, L.P., Kotler, M.L., Lazzari, M.A., Gomez, R.M., Prostacyclin prevents nitric oxide-induced megakaryocyte apoptosis (2005) Br J Pharmacol, 145 (3), pp. 283-292. , Jun
  • Tablin, F., Castro, M., Leven, R.M., Blood platelet formation in vitro. The role of the cytoskeleton in megakaryocyte fragmentation (1990) J Cell Sci, 97, pp. 59-70. , Sep
  • Hartwig, J.H., Italiano, J.E., Jr., Cytoskeletal mechanisms for platelet production (2006) Blood Cells Mol Dis, 36 (2), pp. 99-103. , Mar-Apr
  • Lecine, P., Italiano, J.E., Jr., Kim, S.W., Villeval, J.L., Shivdasani, R.A., Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2 (2000) Blood, 96 (4), pp. 1366-1373. , Aug 15
  • Richardson, J.L., Shivdasani, R.A., Boers, C., Hartwig, J.H., Italiano, J.E., Jr., Mechanisms of organelle transport and capture along proplatelets during platelet production (2005) Blood, 106 (13), pp. 4066-4075. , Dec 15
  • Patel, S.R., Richardson, J.L., Schulze, H., Kahle, E., Galjart, N., Drabek, K., Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes (2005) Blood, 106 (13), pp. 4076-4085. , Dec 15
  • Junt, T., Schulze, H., Chen, Z., Massberg, S., Goerge, T., Krueger, A., Dynamic visualization of thrombopoiesis within bone marrow (2007) Science, 317 (5845), pp. 1767-1770. , Sep 21
  • Nishimura, S., Nagasaki, M., Kunishima, S., Sawaguchi, A., Sakata, A., Sakaguchi, H., IL-1alpha induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs (2015) J Cell Biol, 209 (3), pp. 453-466. , May 11
  • Fliedner, T.M., Calvo, W., Klinnert, V., Nothdurft, W., Prummer, O., Raghavachar, A., Bone marrow structure and its possible significance for hematopoietic cell renewal (1985) Ann N y Acad Sci, 459, pp. 73-84
  • Porwit, A., McCullough, J., Erber, W., (2011) Blood and Bone Marrow Pathology, , 2nd. ed London: Elsevier
  • Kaushansky, K., Thrombopoiesis (2015) Semin Hematol, 52 (1), pp. 4-11. , Jan
  • Kiel, M.J., Morrison, S.J., Maintaining hematopoietic stem cells in the vascular niche (2006) Immunity, 25 (6), pp. 862-864. , Dec
  • Mendez-Ferrer, S., Michurina, T.V., Ferraro, F., Mazloom, A.R., Macarthur, B.D., Lira, S.A., Mesenchymal and haematopoietic stem cells form a unique bone marrow niche (2010) Nature, 466 (7308), pp. 829-834. , Aug 12
  • Calvi, L.M., Adams, G.B., Weibrecht, K.W., Weber, J.M., Olson, D.P., Knight, M.C., Osteoblastic cells regulate the haematopoietic stem cell niche (2003) Nature, 425 (6960), pp. 841-846. , Oct 23
  • Malara, A., Currao, M., Gruppi, C., Celesti, G., Viarengo, G., Buracchi, C., Megakaryocytes contribute to the bone marrow-matrix environment by expressing fibronectin, type IV collagen, and laminin (2014) Stem Cells, 32 (4), pp. 926-937. , Apr
  • Heazlewood, S.Y., Neaves, R.J., Williams, B., Haylock, D.N., Adams, T.E., Nilsson, S.K., Megakaryocytes co-localise with hemopoietic stem cells and release cytokines that up-regulate stem cell proliferation (2013) Stem Cell Res, 11 (2), pp. 782-792. , Sep
  • Malara, A., Abbonante, V., Di Buduo, C.A., Tozzi, L., Currao, M., Balduini, A., The secret life of a megakaryocyte: Emerging roles in bone marrow homeostasis control (2015) Cell Mol Life Sci, 72 (8), pp. 1517-1536. , Apr
  • Foidart, J.M., Reddi, A.H., Immunofluorescent localization of type IV collagen and laminin during endochondral bone differentiation and regulation by pituitary growth hormone (1980) Rev Biol, 75 (1), pp. 130-136. , Mar
  • Sabri, S., Jandrot-Perrus, M., Bertoglio, J., Farndale, R.W., Mas, V.M., Debili, N., Differential regulation of actin stress fiber assembly and proplatelet formation by alpha2beta1 integrin and GPVI in human megakaryocytes (2004) Blood, 104 (10), pp. 3117-3125. , Nov 15
  • Sabri, S., Foudi, A., Boukour, S., Franc, B., Charrier, S., Jandrot-Perrus, M., Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment (2006) Blood, 108 (1), pp. 134-140. , Jul 1
  • Arai, F., Suda, T., Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche (2007) Ann N y Acad Sci, 1106, pp. 41-53. , Jun
  • Pallotta, I., Lovett, M., Rice, W., Kaplan, D.L., Balduini, A., Bone marrow osteoblastic niche: A new model to study physiological regulation of megakaryopoiesis (2009) PLoS One, 4 (12), p. e8359
  • Hamada, T., Mohle, R., Hesselgesser, J., Hoxie, J., Nachman, R.L., Moore, M.A., Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation (1998) J Exp Med, 188 (3), pp. 539-548. , Aug 3
  • Wang, J.F., Liu, Z.Y., Groopman, J.E., The alpha-chemokine receptor CXCR4 is expressed on the megakaryocytic lineage from progenitor to platelets and modulates migration and adhesion (1998) Blood, 92 (3), pp. 756-764. , Aug 1
  • Avecilla, S.T., Hattori, K., Heissig, B., Tejada, R., Liao, F., Shido, K., Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis (2004) Nat Med, 10 (1), pp. 64-71. , Jan
  • Niswander, L.M., Fegan, K.H., Kingsley, P.D., McGrath, K.E., Palis, J., SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury (2014) Blood, 124 (2), pp. 277-286. , Jul 10
  • Pitchford, S.C., Lodie, T., Rankin, S.M., VEGFR1 stimulates a CXCR4-dependent translocation of megakaryocytes to the vascular niche, enhancing platelet production in mice (2012) Blood, 120 (14), pp. 2787-2795. , Oct 4
  • Broudy, V.C., Lin, N.L., Kaushansky, K., Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro (1995) Blood, 85 (7), pp. 1719-1726. , Apr 1
  • Kuter, D.J., Beeler, D.L., Rosenberg, R.D., The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production (1994) Proc Natl Acad Sci U S A, 91 (23), pp. 11104-11108. , Nov 8
  • Sohma, Y., Akahori, H., Seki, N., Hori, T., Ogami, K., Kato, T., Molecular cloning and chromosomal localization of the human thrombopoietin gene (1994) FEBS Lett, 353 (1), pp. 57-61. , Oct 10
  • Bartley, T.D., Bogenberger, J., Hunt, P., Li, Y.S., Lu, H.S., Martin, F., Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl (1994) Cell, 77 (7), pp. 1117-1124. , Jul 1
  • De Sauvage, F.J., Hass, P.E., Spencer, S.D., Malloy, B.E., Gurney, A.L., Spencer, S.A., Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand (1994) Nature, 369 (6481), pp. 533-538. , Jun 16
  • Lok, S., Kaushansky, K., Holly, R.D., Kuijper, J.L., Lofton-Day, C.E., Oort, P.J., Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo (1994) Nature, 369 (6481), pp. 565-568. , Jun 16
  • Wendling, F., Varlet, P., Charon, M., Tambourin, P., MPLV: A retrovirus complex inducing an acute myeloproliferative leukemic disorder in adult mice (1986) Virology, 149 (2), pp. 242-246. , Mar
  • Souyri, M., Vigon, I., Penciolelli, J.F., Heard, J.M., Tambourin, P., Wendling, F., A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors (1990) Cell, 63 (6), pp. 1137-1147. , Dec 21
  • Vigon, I., Mornon, J.P., Cocault, L., Mitjavila, M.T., Tambourin, P., Gisselbrecht, S., Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily (1992) Proc Natl Acad Sci U S A, 89 (12), pp. 5640-5644. , Jun 15
  • Kaushansky, K., Drachman, J.G., The molecular and cellular biology of thrombopoietin: The primary regulator of platelet production (2002) Oncogene, 21 (21), pp. 3359-3367. , May 13
  • Sungaran, R., Markovic, B., Chong, B.H., Localization and regulation of thrombopoietin mRNa expression in human kidney, liver, bone marrow, and spleen using in situ hybridization (1997) Blood, 89 (1), pp. 101-107. , Jan 1
  • Kato, T., Matsumoto, A., Ogami, K., Tahara, T., Morita, H., Miyazaki, H., Native thrombopoietin: Structure and function (1998) Stem Cells, 16 (5), pp. 322-328
  • Hoffman, R.C., Andersen, H., Walker, K., Krakover, J.D., Patel, S., Stamm, M.R., Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246 (1996) Biochemistry, 35 (47), pp. 14849-14861. , Nov 26
  • Dahlen, D.D., Broudy, V.C., Drachman, J.G., Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs (2003) Blood, 102 (1), pp. 102-108. , Jul 1
  • Emmons, R.V., Reid, D.M., Cohen, R.L., Meng, G., Young, N.S., Dunbar, C.E., Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction (1996) Blood, 87 (10), pp. 4068-4071. , May 15
  • Kaushansky, K., The molecular mechanisms that control thrombopoiesis (2005) J Clin Invest, 115 (12), pp. 3339-3347. , Dec
  • Ng, A.P., Kauppi, M., Metcalf, D., Hyland, C.D., Josefsson, E.C., Lebois, M., Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation (2014) Proc Natl Acad Sci U S A, 111 (16), pp. 5884-5889. , Apr 22
  • Kaushansky, K., Lok, S., Holly, R.D., Broudy, V.C., Lin, N., Bailey, M.C., Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin (1994) Nature, 369 (6481), pp. 568-571. , Jun 16
  • Rasko, J.E., O'Flaherty, E., Begley, C.G., Mpl ligand (MGDF) alone and in combination with stem cell factor (SCF) promotes proliferation and survival of human megakaryocyte, erythroid and granulocyte/macrophage progenitors (1997) Stem Cells, 15 (1), pp. 33-42
  • Debili, N., Wendling, F., Katz, A., Guichard, J., Breton-Gorius, J., Hunt, P., The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors (1995) Blood, 86 (7), pp. 2516-2525. , Oct 1
  • Murone, M., Carpenter, D.A., De Sauvage, F.J., Hematopoietic deficiencies in c-mpl and TPO knockout mice (1998) Stem Cells, 16 (1), pp. 1-6
  • Carver-Moore, K., Broxmeyer, H.E., Luoh, S.M., Cooper, S., Peng, J., Burstein, S.A., Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice (1996) Blood, 88 (3), pp. 803-808. , Aug 1
  • Tamura, H., Ogata, K., Luo, S., Nakamura, K., Yokose, N., Dan, K., Plasma thrombopoietin (TPO) levels and expression of TPO receptor on platelets in patients with myelodysplastic syndromes (1998) Br J Haematol, 103 (3), pp. 778-784. , Dec
  • Drachman, J.G., Miyakawa, Y., Luthi, J.N., Dahlen, D.D., Raney, A., Geddis, A.E., Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membraneproximal domain of Mpl are required for cellular proliferation (2002) J Biol Chem, 277 (26), pp. 23544-23553. , Jun 28
  • Drachman, J.G., Millett, K.M., Kaushansky, K., Thrombopoietin signal transduction requires functional JAK2, not TYK2 (1999) J Biol Chem, 274 (19), pp. 13480-13484. , May 7
  • Miyakawa, Y., Rojnuckarin, P., Habib, T., Kaushansky, K., Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes (2001) J Biol Chem, 276 (4), pp. 2494-2502. , Jan 26
  • Geddis, A.E., Fox, N.E., Kaushansky, K., Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary megakaryocytic progenitors (2001) J Biol Chem, 276 (37), pp. 34473-34479. , Sep 14
  • Rojnuckarin, P., Drachman, J.G., Kaushansky, K., Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: Role in endomitosis (1999) Blood, 94 (4), pp. 1273-1282. , Aug 15
  • Yoshida, M., Tsuji, K., Ebihara, Y., Muraoka, K., Tanaka, R., Miyazaki, H., Thrombopoietin alone stimulates the early proliferation and survival of human erythroid, myeloid and multipotential progenitors in serum-free culture (1997) Br J Haematol, 98 (2), pp. 254-264. , Aug
  • Jacobsen, S.E., Borge, O.J., Ramsfjell, V., Cui, L., Cardier, J.E., Veiby, O.P., Thrombopoietin, a direct stimulator of viability and multilineage growth of primitive bone marrow progenitor cells (1996) Stem Cells, 14, pp. 173-180
  • Mitchell, W.B., Bussel, J.B., Thrombopoietin receptor agonists: A critical review (2015) Semin Hematol, 52 (1), pp. 46-52. , Jan
  • Balduini, C.L., Pecci, A., Savoia, A., Recent advances in the understanding and management of MYH9-related inherited thrombocytopenias (2011) Br J Haematol, 154 (2), pp. 161-174. , Jul
  • Favier, R., Feriel, J., Favier, M., Denoyelle, F., Martignetti, J.A., First successful use of eltrombopag before surgery in a child with MYH9-related thrombocytopenia (2013) Pediatrics, 132 (3), pp. e793-e795. , Sep
  • Marshall, A.L., Goodarzi, K., Kuter, D.J., Romiplostim in the management of the thrombocytopenic surgical patient (2015) Transfusion, 55 (10), pp. 2505-2510. , Oct
  • Bussel, J.B., Kuter, D.J., Aledort, L.M., Kessler, C.M., Cuker, A., Pendergrass, K.B., A randomized trial of avatrombopag, an investigational thrombopoietin-receptor agonist, in persistent and chronic immune thrombocytopenia (2014) Blood, 123 (25), pp. 3887-3894. , Jun 19

Citas:

---------- APA ----------
Rivadeneyra, L., Ivani, P.C., Schattner, M. & Pozner, R.G. (2016) . The birth of a platelet: A trip from bone marrow megakaryocytes to circulating platelets . Acta Bioquimica Clinica Latinoamericana, 50(2), 233-245.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n2_p233_Rivadeneyra [ ]
---------- CHICAGO ----------
Rivadeneyra, L., Ivani, P.C., Schattner, M., Pozner, R.G. "The birth of a platelet: A trip from bone marrow megakaryocytes to circulating platelets " . Acta Bioquimica Clinica Latinoamericana 50, no. 2 (2016) : 233-245.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n2_p233_Rivadeneyra [ ]
---------- MLA ----------
Rivadeneyra, L., Ivani, P.C., Schattner, M., Pozner, R.G. "The birth of a platelet: A trip from bone marrow megakaryocytes to circulating platelets " . Acta Bioquimica Clinica Latinoamericana, vol. 50, no. 2, 2016, pp. 233-245.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n2_p233_Rivadeneyra [ ]
---------- VANCOUVER ----------
Rivadeneyra, L., Ivani, P.C., Schattner, M., Pozner, R.G. The birth of a platelet: A trip from bone marrow megakaryocytes to circulating platelets . Acta Bioquim. Clin. Latinoam. 2016;50(2):233-245.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n2_p233_Rivadeneyra [ ]