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Referencias:

• Castro, J.A., Zerba, E.N., De Licastro, S.A., Picollo, M.I., Wood, E.J., Ruveda, M.A., Toxicity of methyl bromide and other gaseous insecticides to Triatoma infestans (1976) Acta Physiol Lat Am, 26, pp. 106-114
• Castro, J.A., Diaz De Toranzo, E.G., Toxic effects of nifurtimox and benznidazole, two drugs used against American trypanosomiasis (Chagas' disease) (1988) Biomed Environ Sci, 1, pp. 19-33
• Castro, J.A., Toxicology in problem detection and as problem solving for tropical diseases (1996) The Latin American Example of Chagas' Disease. Proceedings of the Third Congress of Toxicology in Developing Countries, 1, pp. 109-124
• Castro, J.A., Contribution of toxicology to the problem of chagas disease (American trypanosomiasis). A year 2000 update (2000) Biomed Environ Sci, 13, pp. 271-279
• Castro, J.A., De Mecca, M.M., Bartel, L.C., Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis) (2006) Hum Exp Toxicol, 25, pp. 471-479
• Docampo, R., Mason, R.P., Mottley, C., Muniz, R.P., Generation of free radicals induced by nifurtimox in mammalian tissues (1981) J Biol Chem, 256, pp. 10930-10933
• Masana, M., De Toranzo, E.G.D., Castro, J.A., Reductive metabolism and activation of Benznidazole (1984) Biochem Pharmacol, 33, pp. 1041-1045
• Masana, M., De Toranzo, E.G.D., Castro, J.A., Studies on Nifurtimox nitroreductase activity in liver and other rat tissues (1984) Arch Int Pharmacodyn Ther, 270, pp. 4-10
• Masana, M., De Toranzo, E.G., Castro, J.A., Reductive metabolism and activation of benznidazole, a drug against Chagas' disease (1983) Dev Toxicol Environ Sci, 11, pp. 383-386
• De Toranzo, E.G.D., Masana, M., Castro, J.A., Nitroreduction of Benznidazole and Nifurtimox by rat and human feces (1983) Res Commun Chem Pathol Pharmacol, 41, pp. 341-344
• Aguilar, E.G., De Arranz, C.K., De Toranzo, E.G., Castro, J.A., Liver microsomal Benznidazole and Nifurtimox nitroreductase activity in male rats of different age (1987) Arch Int Pharmacodyn Ther, 289, pp. 11-17
• Bulffer, R.F., Castro, J.A., Fanelli, S.L., Benznidazole levels in blood vary with age in rats (2011) Mem Inst Oswaldo Cruz, 106, pp. 374-377
• Díaz De Toranzo, E.G., Castro, J.A., De Cazzulo, B.M.F., Cazzulo, J.J., Interaction of Benznidazole reactive metabolites with nuclear and kinetoplastic DNA; Proteins and lipids from Trypanosoma cruzi (1988) Experientia, 44, pp. 880-881
• Gorla, N., Diaz Gomez, M.I., Castro, J.A., Interaction of Benznidazole reactive metabolites with rat liver deoxyribonucleic acid and nuclear proteins (1986) Arch Int Pharmacodyn Ther, 280, pp. 22-31
• De Toranzo, E.G.D., Herrera, D.M., Castro, J.A., Rat liver nuclear Nifurtimox nitroreductase activity (1997) Res Commun Mol Pathol Pharmacol, 98, pp. 249-254
• Gorla, N.B., Castro, J.A., Micronucleus formation in bone marrow of mice treated with Nifurtimox or Benznidazole (1985) Toxicol Lett, 25, pp. 259-263
• Montalto De Mecca, M., Diaz, E.G., Castro, J.A., Nifurtimox biotransformation to reactive metabolites or nitrite in liver subcellular fractions and model systems (2002) Toxicol Lett, 136, pp. 1-8
• Díaz, E.G., De Mecca, M.M., Castro, J.A., Reactions of Nifurtimox with critical thiol-containing biomolecules. Their potential toxicological relevance (2004) J Applied Toxicol, 24, pp. 189-195
• Aguilar, E.G., Koldobsky, C., De Toranzo, E.G., Castro, J.A., Species and sex differences in the liver microsomal nitroreductive biotransformation of Nifurtimox and Benznidazole (1987) Arch Int Pharmacodyn Ther, 287, pp. 181-187
• Bartel, L.C., Montalto De Mecca, M., De Castro, C.R., Bietto, F.M., Castro, J.A., Metabolization of nifurtimox and benznidazole in cellular fractions of rat mammary tissue (2010) Hum Exp Toxicol, 29, pp. 813-822
• Bartel, L.C., Montalto De Mecca, M., Castro, J.A., Nitroreductive metabolic activation of some carcinogenic nitro heterocyclic food contaminants in rat mammary tissue cellular fractions (2009) Food Chem Toxicol, 47, pp. 140-144
• Bernacchi, A.S., De Castro, C.R., De Toranzo, E.G.D., Castro, J.A., Effects of Nifurtimox or Benznidazole administration on rat testes: Ultrastructural observation and biochemical studies (1986) Exp Mol Pathol, 45, pp. 245-256
• De Castro, C.R., De Toranzo, E.G.D., Bernacchi, A.S., Carbone, M., Castro, J.A., Ultrastructural alterations in ovaries from Nifurtimox or Benznidazole-treated rats. Their relation to ovarian nitroreductive biotransformation of both drugs (1989) Exp Mol Pathol, 50, pp. 385-397
• De Toranzo, E.G.D., Masana, M., Castro, J.A., Administration of Benznidazole, a chemotherapeutic agent against Chagas' disease to pregnants rats. Covalent binding of reactive metabolites to fetal and maternal proteins (1984) Arch Int Pharmacodyn Ther, 272, pp. 17-23
• De Castro, C.R., De Toranzo, E.G.D., Carbone, M., Castro, J.A., Ultrastructural effects of Nifurtimox on rat adrenal cortex related to reductive biotransformation (1990) Exp Mol Pathol, 52, pp. 98-108
• De Castro, C.R., De Toranzo, E.G.D., Castro, J.A., Benznidazole-induced ultrastructural alterations in rat adrenal cortex. Mechanistic studies (1992) Toxicology, 74, pp. 223-232
• De Mecca, M.M., Fanelli, S.L., Bartel, L.C., De Castro, C.R., Díaz, E.G., Castro, J.A., Nifurtimox nitroreductase activity in different cellular fractions from male rat pancreas. Biochemical and ultrastructural alterations (2007) Life Sci, 81, pp. 144-152
• Montalto De Mecca, M.M., Rodríguez De Castro, C., Díaz, E.G., Castro, J.A., Alteraciones ultraestructurales en la mucosa del colon de ratas tratadas con Nifurtimox (2001) Medicina (Buenos Aires), 61, pp. 67-72
• Díaz, E.G., De Castro, C.R., De Mecca, M.M., Castro, J.A., Benznidazole-induced ultrastructural and biochemical alterations in the rat colon (2000) Acta Pharmacol Sin, 21, pp. 961-966
• De Castro, C.R., De Mecca, M.M., Fanelli, S.L., De Ferreyra, E.C., Diaz, E.G., Castro, J.A., Benznidazole-induced ultrastructural and biochemical alterations in rat esophagus (2003) Toxicology, 191, pp. 189-198
• Bartel, L.C., De Mecca, M.M., Fanelli, S.L., Rodríguez De Castro, C., Díaz, E.G., Castro, J.A., Early Nifurtimox induced biochemical and ultrastructural alterations in rat heart (2007) Human Exp Toxicol, 26, pp. 781-788
• Mecca, M.M., Bartel, L.C., Castro, C.R., Castro, J.A., Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: Comparison to Nifurtimox-induced cardiac effects (2008) Mem Inst Oswaldo Cruz, 103, pp. 549-553
• Montalto De Mecca, M., Bernacchi, A.S., Castro, J.A., Prevention of benznidazole-induced prolonging effect on the pentobarbital sleeping time of rats using different thiol-containing compounds (2000) Res Commun Mol Pathol Pharmacol, 108, pp. 39-48
• Castro, G.D., Castro, J.A., Studies on pentane evolution by rats treated with Nifurtimox or Benznidazole (1985) Toxicology, 35, pp. 319-326
• Bulffer, R.F., Castro, J.A., Fanelli, S.L., Metodología UV para la determinación de los antichagásicos Nifurtimox y Benznidazol en sangre (2011) Acta Bioquím Clín Latinoam, 45, pp. 463-470
• De Mecca, M.M., Bartel, L.C., Castro, J.A., Effect of chronic alcohol drinking on rat liver microsomal nitroreductive metabolism of nifurtimox and benznidazole (2013) Hum Exp Toxicol, 32, pp. 1305-1310
• Franke De Cazzulo, B.M., Bernacchi, A., Esteva, M.I., Ruiz, A.M., Castro, J.A., Cazzulo, J.J., Trypanocidal effect of SKF525A, proadifen, on different developmental forms of Trypanosoma cruzi (1998) Medicina (Buenos Aires), 58, pp. 415-418
• Bernacchi, A.S., Franke De Cazzulo, B., Castro, J.A., Trypanocidal action of 2,4-dichloro-6-phenylphenoxyethyl diethylamine hydrobromide (Lilly 18947) on Trypanosoma cruzi (2002) Acta Pharmacol Sin, 23, pp. 399-404
• Lacuara, J.L., De Barioglio, S.R., De Oliva, P.P., Bernacchi, A.S., De Culasso, A.F., Castro, J.A., Disruption of mitochondrial function as the basis of the trypanocidal effect of trifluoperazine on Trypanosoma cruzi (1991) Experientia, 47, pp. 612-616
• Díaz Gómez, M.I., Castro, J.A., Genotoxicidad en leucocitos por la quimioprofilaxis de sangre con Violeta de Genciana y su prevención con antioxidantes (2013) Acta Bioquím Clín Latinoam, 47, pp. 719-726

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