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Abstract:

Dermatan sulfate (DS) is well-known for its anticoagulant activity by binding to heparin cofactor II in order to enhance the antithrombin action. It has also been suggested that DS has a profibrinolytic effect, although the exact molecular mechanism is unknown. This review exposes the results obtained and discusses on the available literature on DS effect on the fibrynolytic system. DS exhibited a stimulating effect on the activation of plasminogen by plasminogen activators (t-PA and u-PA), by in vitro amidolytic and coagulometric methods, showing a pro-fibrinolytic effect independent of its known anticoagulant action. Studies of fibrin networks obtained in the presence of DS showed longer and thinner fibers than controls, increased degree of compaction and lisability. Thus, DS displayed a pro-fibrinolytic effect associated to its anticoagulant action. These results contribute to clarify the mechanism of DS action on the plasminogen-plasmin system and to the understanding of the physiologic role of this glycosaminoglycan.

Registro:

Documento: Artículo
Título:Glycosaminoglyeans on hemostasis: Dermatan sulfate action on the fibrinolytic system
Autor:Castañon, M.M.
Filiación:Doctora de la Universidad de Buenos Aires, Área Ciencias Químicas, Mexico
Laboratorio de Hemostasia y Trombosis, Departamento de Química Biológica, Piso 4. Ciudad Universitaria, C1428EHA Ciudad Autónoma de Buenos Aires, Argentina
Palabras clave:Dermatan sulfate; Fibrin network; Lisability; Plasminogen activation; Structure; Tissue plasminogen activator; Urine plasminogen activator
Año:2008
Volumen:42
Número:4
Página de inicio:509
Página de fin:528
Título revista:Acta Bioquimica Clinica Latinoamericana
Título revista abreviado:Acta Bioquim. Clin. Latinoam.
ISSN:03252957
CODEN:ABCLD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v42_n4_p509_Castanon

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Citas:

---------- APA ----------
(2008) . Glycosaminoglyeans on hemostasis: Dermatan sulfate action on the fibrinolytic system . Acta Bioquimica Clinica Latinoamericana, 42(4), 509-528.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v42_n4_p509_Castanon [ ]
---------- CHICAGO ----------
Castañon, M.M. "Glycosaminoglyeans on hemostasis: Dermatan sulfate action on the fibrinolytic system " . Acta Bioquimica Clinica Latinoamericana 42, no. 4 (2008) : 509-528.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v42_n4_p509_Castanon [ ]
---------- MLA ----------
Castañon, M.M. "Glycosaminoglyeans on hemostasis: Dermatan sulfate action on the fibrinolytic system " . Acta Bioquimica Clinica Latinoamericana, vol. 42, no. 4, 2008, pp. 509-528.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v42_n4_p509_Castanon [ ]
---------- VANCOUVER ----------
Castañon, M.M. Glycosaminoglyeans on hemostasis: Dermatan sulfate action on the fibrinolytic system . Acta Bioquim. Clin. Latinoam. 2008;42(4):509-528.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v42_n4_p509_Castanon [ ]