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Abstract:

Fibrin is a protein network present in the clot. It can be characterized by its structure, fibers dimensions, ramification degree, porosity, viscoelasticity and deformability. All these properties depend on temperature, ions concentrations and on other plasmatic substances, mainly fibrinogen, thrombin and factor XIII. Greater fibrinogen or thrombin concentrations produce more dense, less porous and shorter fibered-fibrin networks. Fibrinogen alterations can generate abnormal fibrin, with different susceptibility to lysis, while calcium ions increase the fibrin networks' rigidity and porosity. Plasminogen activation and fibrinolysis rate are strongly dependent on the size and the fibrin network architecture. Tight networks are lysed more slowly while, within the same gel, thin fibers are lysed before thick ones. Otherwise, thicker fibers proved to be a better cofactor of plasminogen activation. Taking into account these factors helps understand the different fibrinolytic response, mainly when it is not explained by laboratory studies.

Registro:

Documento: Artículo
Título:Fibrin network variability
Autor:Lauricella, A.M.
Filiación:Universidad de Buenos Aires, Área Química Biológica, Argentina
Int. Güiraldes 2160, Pabellón II, Ciudad Universitaria, C1428EHA Cd. Auton. de Buenos Aires, Argentina
Palabras clave:Fibrin; Fibrin properties; Fibrin-formation; Fibrinogen
Año:2007
Volumen:41
Número:1
Página de inicio:7
Página de fin:19
Título revista:Acta Bioquimica Clinica Latinoamericana
Título revista abreviado:Acta Bioquim. Clin. Latinoam.
ISSN:03252957
CODEN:ABCLD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v41_n1_p7_Lauricella

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Citas:

---------- APA ----------
(2007) . Fibrin network variability . Acta Bioquimica Clinica Latinoamericana, 41(1), 7-19.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v41_n1_p7_Lauricella [ ]
---------- CHICAGO ----------
Lauricella, A.M. "Fibrin network variability " . Acta Bioquimica Clinica Latinoamericana 41, no. 1 (2007) : 7-19.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v41_n1_p7_Lauricella [ ]
---------- MLA ----------
Lauricella, A.M. "Fibrin network variability " . Acta Bioquimica Clinica Latinoamericana, vol. 41, no. 1, 2007, pp. 7-19.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v41_n1_p7_Lauricella [ ]
---------- VANCOUVER ----------
Lauricella, A.M. Fibrin network variability . Acta Bioquim. Clin. Latinoam. 2007;41(1):7-19.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v41_n1_p7_Lauricella [ ]