Artículo
Dubinsky, V.; Junovich, G.; Gutiérrez, G. "Innate immune response between environmental factors and abortion: Lipopolysaccharide tolerization model during gestation " (2006) Acta Bioquimica Clinica Latinoamericana. 40(1):71-76
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Abstract:
The exacerbated local inflammatory response that triggers immunological abortion on CBA/j x DBA/2 murine model depends on environmental factors such as LPS. Since deficient Tlr4 mice are resistant to LPS-induced abortion, the effect of LPS tolerization on the prevention of fetal losses, as well as on the synthesis of placental cytokines on CBA/j x DBA/2 model has been studied. Low doses of LPS were inoculated during pre and post-implantatory stages on CBA/j pregnant mice. In order to investigate tolerization effect, abortogenic doses of LPS were added to placental and splenocyte cul-Results obtained with post-implantatory inoculation of 1μg/day LPS showed a decrease in the abortion rate as well as an IL-6 hyporesponsive to LPS booster, both in placenta and splenocyte cultures. However, stimulation with abortogenic dose of LPS modified TNF-α levels by an increase in placenta but a decrease in splenocyte culture supernatants. Considering these results, it can be concluded that LPS tolerance induction depends on the organ as well as on the cytokine studied.
Registro:
| Documento: | Artículo |
| Título: | Innate immune response between environmental factors and abortion: Lipopolysaccharide tolerization model during gestation |
| Autor: | Dubinsky, V.; Junovich, G.; Gutiérrez, G. |
| Filiación: | Ciencias Biológicas de la FCEyN de la UBA, Argentina Ciencias de la UBA, Área Inmunología de la Reproducción Instituto de Estudios de la Inmunidad Humoral (IDEHU)/Cátedra de Inmunología, FFyB, Universidad de Buenos Aires, Junín 956 4P (1113), Buenos Aires, Argentina Instituto de Estudios de la Inmunidad Humoral (IDEHU), Cátedra de Inmunología, Universidad de Buenos Aires, Junín 956 4P, 1113 Cd. Auton. de Buenos Aires, Argentina |
| Palabras clave: | Abortion; Cytokines; Innate immune response; Lipopolysaccharide; Tolerization; Murinae |
| Año: | 2006 |
| Volumen: | 40 |
| Número: | 1 |
| Página de inicio: | 71 |
| Página de fin: | 76 |
| Título revista: | Acta Bioquimica Clinica Latinoamericana |
| Título revista abreviado: | Acta Bioquim. Clin. Latinoam. |
| ISSN: | 03252957 |
| CODEN: | ABCLD |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n1_p71_Dubinsky |
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Citas:
---------- APA ----------
Dubinsky, V., Junovich, G. & Gutiérrez, G. (2006) . Innate immune response between environmental factors and abortion: Lipopolysaccharide tolerization model during gestation . Acta Bioquimica Clinica Latinoamericana, 40(1), 71-76.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n1_p71_Dubinsky [ ]
---------- CHICAGO ----------
Dubinsky, V., Junovich, G., Gutiérrez, G. "Innate immune response between environmental factors and abortion: Lipopolysaccharide tolerization model during gestation " . Acta Bioquimica Clinica Latinoamericana 40, no. 1 (2006) : 71-76.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n1_p71_Dubinsky [ ]
---------- MLA ----------
Dubinsky, V., Junovich, G., Gutiérrez, G. "Innate immune response between environmental factors and abortion: Lipopolysaccharide tolerization model during gestation " . Acta Bioquimica Clinica Latinoamericana, vol. 40, no. 1, 2006, pp. 71-76.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n1_p71_Dubinsky [ ]
---------- VANCOUVER ----------
Dubinsky, V., Junovich, G., Gutiérrez, G. Innate immune response between environmental factors and abortion: Lipopolysaccharide tolerization model during gestation . Acta Bioquim. Clin. Latinoam. 2006;40(1):71-76.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n1_p71_Dubinsky [ ]
