Artículo

Pérez, G.; Vittori, D.; Pregi, N.; Garbossa, G.; Nesse, A. "Iron homeostasis. Mechanisms of absorption, uptake and regulation " (2005) Acta Bioquimica Clinica Latinoamericana. 39(3):301-314
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Abstract:

Iron is an essential nutrient required by every living being. This transition metal is involved in the majority of the metabolic processes, partly because of its ability to reversibly and readily cycle between ferrous (Fe 2+) and ferric (Fe3+) oxidation states. Iron must be transported and stored as a component of protein complexes. Ferric ions circulate bound to plasma protein transferrin and accumulate within cells in the form of ferritin or hemosiderin. This is due to the fact that iron as a free cation can participate in a number of reactions to produce free radical species, which in turn can severely damage organs. Taking into account that both iron deficiency and iron overload are deleterious, a strict balance between iron absorption and utilization is required. In this work, the distinct pathways of gastrointestinal absorption and cellular uptake of iron are reviewed, giving details of the mechanisms involved in iron homeostasis under different conditions. Condition of iron deficiency and overload are discussed in terms of mechanisms leading to restoration of iron homeostasis.

Registro:

Documento: Artículo
Título:Iron homeostasis. Mechanisms of absorption, uptake and regulation
Autor:Pérez, G.; Vittori, D.; Pregi, N.; Garbossa, G.; Nesse, A.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas Y Naturales, Ciudad Universitaria, Ciudad Autonoma de Buenos Aires, Argentina
Palabras clave:Anemia; Hemochromatosis; Hepcidin; Iron; Non-transferrin bound iron uptake; Transferrin; Transferrin receptors
Año:2005
Volumen:39
Número:3
Página de inicio:301
Página de fin:314
Título revista:Acta Bioquimica Clinica Latinoamericana
Título revista abreviado:Acta Bioquim. Clin. Latinoam.
ISSN:03252957
CODEN:ABCLD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n3_p301_Perez

Referencias:

  • Aisen, P., Listowsky, I., Iron and storage proteins (1980) Annu Rev Biochem, 49, pp. 357-393
  • Ponka, P., Tissue-specific regulation of iron metabolism and heme synthesis: Distinct control mechanisms in erythroid cells (1997) Blood, 89, pp. 1-25
  • Crichton, R.R., Wilmet, S., Legssyer, R., Ward, R.J., Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells (2002) J Inorg Biochem, 91, pp. 9-18
  • Conrad, M.E., Umbreit, J.N., Peterson, R.D., Moore, E.G., Harper, K.P., Function of integrin in duodenal mucosal uptake of iron (1993) Blood, 81, pp. 517-521
  • Latunde-Dada, G.O., Van Der Westhuizen, J., Vulpe, C.D., Anderson, G.J., Simpson, R.J., McKie, A.T., Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism (2002) Blood Cells Mol Dis, 29, pp. 356-360
  • Fleming, M.D., Romano, M.A., Su, M.A., Garrick, L.M., Garrick, M.D., Andrews, N.C., Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport (1998) Proc Natl Acad Sci, 95, pp. 1148-1153. , USA
  • Uzel, C., Conrad, M.E., Absorption of heme iron (1998) Semin Hematol, 35, pp. 27-34
  • Worthington, M.T., Cohn, S.M., Miller, S.K., Luo, R.Q., Berg, C.L., Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines (2001) Am J Physiol Gastrointest Liver Physiol, 280, pp. 1172-1177
  • Umbreit, J.N., Conrad, M.E., Moore, E.G., Desai, M.P., Turrens, J., Paraferritin: A protein complex with ferrireductase activity is associated with iron absorption in rats (1996) Biochemistry, 35, pp. 6460-6469
  • Kaplan, J., Mechanisms of cellular iron acquisition: Another iron in the fire (2002) Cell, 111, pp. 603-606
  • Conrad, M.E., Umbreit, J.N., Iron absorption and transport-an update (2000) Am J Hematol, 64, pp. 287-298
  • Nemeth, E., Tuttle, M.S., Powelson, J., Vaughn, M.B., Donovan, A., McVey Ward, D., Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization (2004) Science, 306, pp. 2090-2093
  • Leong, W.-I., Lönerdal, B., Hepcidin, the recently identified peptide that appears to regulate iron absorption (2004) J Nutr, 134, pp. 1-4
  • Muñoz Gómez, M., Campos Garríguez, A., García Erce, J.A., Ramírez Ramírez, G., Fisiopatología del metabolismo del hierro: Implicaciones diagnósticas y terapéuticas (2005) Nefrología, 25, pp. 9-19
  • Baker, E.N., Lindley, P.F., New perspectives on the structure and function of transferrins (1992) J Inorg Biochem, 47, pp. 147-160
  • Pakdaman, R., El Hage Chahine, J.M., A mechanism for iron uptake by transferrin (1996) Eur J Biochem, 236, pp. 922-931
  • Bali, P.K., Aisen, P., Receptor-induced switch in site-site cooperativity during iron release by transferrin (1992) Biochemistry, 31, pp. 3963-3967
  • Van Eijk, H.G., De Jong, G., The physiology of iron, transferrin, and ferritin (1992) Biol Trace Element Res, 35, pp. 13-24
  • Huebers, H.A., Finch, C.A., The physiology of transferrin and transferrin receptors (1987) Physiol Rev, 67, pp. 520-582
  • Beguin, Y., The soluble transferrin receptor: Biological aspects and clinical usefulness as quantitative measure of erythropoiesis (1992) Haematologica, 77, pp. 1-10
  • Brittenham, G.M., Disorders of Iron Metabolism: Iron deficiency and overload (2000) Hematology: Basic Principles and Practice. 3rd Ed., pp. 397-427. , Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P, editors. New York: Churchill Livingstone
  • Wileman, T., Harding, C., Stahl, P., Receptor-mediated endocytosis (1985) Biochem J, 232, pp. 1-14
  • Gruenheid, S., Canonne-Hergaux, F., Gauthier, S., Hackam, D.J., Grinstein, S., Gros, P., The iron transport protein NRAMP2 is an integrated membrane glycoprotein that colocalizes with transferrin in recycling endosomes (1999) J Exp Med, 189, pp. 831-841
  • Young, S.P., Bomford, A., Iterative endocytosis of transferrin by K562 cells (1994) Biochem J, 298, pp. 165-170
  • Klausner, R.D., Rouault, T.A., Harford, J.B., Regulating the fate of mRNA: The control of cellular iron metabolism (1993) Cell, 72, pp. 19-28
  • Hentze, M.W., Kühn, L.C., Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress (1996) Proc Natl Acad Sci, 93, pp. 8175-8182. , USA
  • Kaldy, P., Menotti, E., Moret, R., Kühn, L.C., Identification of RNA-binding surfaces in iron regulatory protein-1 (1999) EMBO J, 18, pp. 6073-6083
  • Iwai, K., Klausner, R.D., Rouault, T.A., Requeriments for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2 (1995) EMBO J, 14, pp. 5350-5357
  • Casey, J.L., Hentze, M.W., Koeller, D.M., Caughman, S.W., Rouault, T.A., Klausner, R.D., Iron-responsive elements: Regulatory RNA sequences that control mRNA levels and translation (1988) Science, 240, pp. 924-928
  • Leibold, E.A., Munro, H.N., Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunit mRNAs (1988) Proc Natl Acad Sci, 85, pp. 2171-2175. , USA
  • Cox, T.C., Bawden, M.J., Martin, A., May, B.K., Human erythroid 5-aminolevulinate synthase: Promoter analysis and identification of an iron-responsive element in the mRNA (1991) EMBO J, 10, pp. 1891-1902
  • Kawabata, H., Yang, R., Hirama, T., Vuong, P.T., Kawano, S., Gombart, A.F., Molecular cloning of transferrin receptor 2 (1999) J Biol Chem, 274, pp. 20826-20832
  • Kawabata, H., Germain, R.S., Vuong, P.T., Nakamaki, T., Said, J.W., Koeffler, H.P., Transferrin receptor 2-α supports cell growth both in iron-chelated cultured cells and in vivo (2000) J Biol Chem, 275, pp. 16618-16625
  • West, A.P., Bennett, M.J., Sellers, V.M., Andrews, N.C., Enns, C.A., Bjorkman, P.J., Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE (2000) J Biol Chem, 275, pp. 38135-38138
  • Fleming, R.E., Migas, M.C., Holden, C.C., Waheed, A., Britton, R.S., Tomatsu, S., Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis (2000) Proc Natl Acad Sci, 97, pp. 2214-2219. , USA
  • Kawabata, H., Germain, R.S., Ikezoe, T., Tong, X., Green, E.M., Gombart, A.F., Regulation of expression of murine transferrin receptor 2 (2001) Blood, 98, pp. 1949-1954
  • Sturrock, A., Alexander, J., Lamb, J., Craven, C.M., Kaplan, J., Characterization of a transferrin-independent uptake system for iron in HeLa cells (1990) J Biol Chem, 265, pp. 3139-3145
  • Conrad, M.E., Umbreit, J.N., Moore, E.G., Uzel, C., Berry, M.R., Alternate iron transport pathway (1994) J Biol Chem, 269, pp. 7169-7173
  • Jordan, I., Kaplan, J., The mammalian transferrin-independent iron transport system may involve a surface ferrireductase activity (1994) Biochem J, 302, pp. 875-879
  • Akompong, T., Inman, R.S., Wessling-Resnick, M., Phorbol esters stimulate non-transferrin iron uptake by K562 cells (1995) J Biol Chem, 270, pp. 20937-20941
  • Attieh, Z.K., Mukhopadhyay, C.K., Seshadri, V., Tripoulas, N.A., Fox, P.L., Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cationspecific transport mechanism (1999) J Biol Chem, 274, pp. 1116-1123
  • Randell, E.W., Parkes, J.G., Olivieri, N.F., Templeton, D.M., Uptake of non-transferrin-bound iron by both reductive and nonreductive processes is modulated by intracellular iron (1994) J Biol Chem, 269, pp. 16046-16053
  • Inman, R.S., Wessling-Resnick, M., Characterization of transferrin-independent iron transport in K562 cells (1993) J Biol Chem, 268, pp. 8521-8528
  • Canonne-Hergaux, F., Zhang, A.S., Ponka, P., Gros, P., Characterization of the iron transporter DMT1 (NRAMP 2/DCT1) in red blood cells of normal and anemic mk/mk mice (2001) Blood, 98, pp. 3823-3830
  • Kaplan, J., Jordan, I., Sturrock, A., Regulation of the transferrin-independent iron transport system in cultured cells (1991) J Biol Chem, 266, pp. 2997-3004
  • Olakanmi, O., Stokes, J.B., Pathan, S., Britigan, B.E., Polyvalent cationic metals induce the rate of transferrin-independent iron acquisition by HL-60 cells (1997) J Biol Chem, 272, pp. 2599-2606
  • Pérez, G., Pregi, N., Vittori, D., Di Risio, C., Garbossa, G., Nesse, A., Aluminum exposure affects transferrin-dependent and -independent iron uptake by K562 cells (2005) Biochim Biophys Acta, 1745, pp. 124-130
  • Chanarin, I., Anaemia and red blood cell hyperplasia (1992) Oxford Textbook of Pathology, pp. 1692-1695. , McGee J, Isaacson P, Wright N, editors. New York: Oxford University Press
  • Canonne-Hergaux, F., Gruenheid, S., Ponka, P., Gros, P., Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron (1999) Blood, 93, pp. 4406-4417
  • Lee, P.L., Gelbart, T., West, C., Halloran, C., Beutler, E., The human Nramp2 gene: Characterization of the gene structure, alternative splicing, promoter region and polymorphisms (1998) Blood Cells Mol Dis, 24, pp. 199-215
  • Frazer, D.M., Wilkins, S.J., Becker, E.M., Murphy, T.L., Vulpe, C.D., McKie, A.T., A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption (2003) Gut, 52, pp. 340-346
  • Chapman, R.W., Iron overload of the liver (1992) Oxford Textbook of Pathology, pp. 1369-1372. , McGee J, Isaacson P, Wright N, editors. New York: Oxford University Press
  • Roy, C.N., Andrews, N.C., Recent advances in disorders of iron metabolism: Mutations, mechanisms and modifiers (2001) Hum Mol Genet, 10, pp. 2181-2186
  • Andrews, N.C., Disorders of iron metabolism (1999) N Engl J Med, 341, pp. 1986-1995
  • Feder, J.N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D.A., Basava, A., A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis (1996) Nat Genet, 13, pp. 399-408
  • Waheed, A., Parkkila, S., Saarnio, J., Fleming, R.E., Zhou, X.Y., Tomatsu, S., Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum (1999) Proc Natl Acad Sci, 96, pp. 1579-1584. , USA
  • Roy, C.N., Penny, D.M., Feder, J.N., Enns, C.A., The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells (1999) J Biol Chem, 274, pp. 9022-9028
  • Waheed, A., Grubb, J.H., Zhou, X.Y., Tomatsu, S., Fleming, R.E., Costaldi, M.E., Regulation of transferrinmediated iron uptake by HFE, the protein defective in hereditary hemochromatosis (2002) Proc Natl Acad Sci, 99, pp. 3117-3122. , USA
  • Fleming, R.E., Migas, M.C., Zhou, X., Jiang, J., Britton, R.S., Brunt, E.M., Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: Increased duodenal expression of the iron transporter DMT1 (1999) Proc Natl Acad Sci, 96, pp. 3143-3148. , USA
  • Stuart, K.A., Anderson, G.J., Frazer, D.M., Powell, L.W., McCullen, M., Fletcher, L.M., Duodenal expression of iron transport molecules in untreated haemochromatosis subjects (2003) Gut, 52, pp. 953-959
  • Weiss, G., Pathogenesis and treatment of anaemia of chronic disease (2002) Blood Reviews, 16, pp. 87-96
  • Means, R.T., Recent developments in the anemia of chronic disease (2003) Curr Hematol Rep, 2, pp. 116-121
  • Roy, C.N., Weinstein, D.A., Andrews, N.C., 2002 E. Mead Johnson Award for Research in Pediatrics Lecture: The Molecular Biology of the Anemia of Chronic Disease: A Hypothesis (2003) Pediatr Res, 53, pp. 507-512
  • Nemeth, E., Valore, E.V., Territo, M., Schiller, G., Lichtenstein, A., Ganz, T., Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein (2003) Blood, 101, pp. 2461-2463
  • Weinstein, D.A., Roy, C.N., Fleming, M.D., Loda, M.F., Wolfsdorf, J.I., Andrews, N.C., Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease (2002) Blood, 100, pp. 3776-3781
  • Del Castillo Rueda, A., De Portugal Alvarez, J., Hepcidina, una nueva proteína en la homeostasis del hierro (2003) An Med Intern, 20, pp. 605-606. , Madrid
  • Roy, C.N., Andrews, N.C., Anemia of inflammation: The hepcidin link (2005) Curr Opin Hematol, 12, pp. 107-111

Citas:

---------- APA ----------
Pérez, G., Vittori, D., Pregi, N., Garbossa, G. & Nesse, A. (2005) . Iron homeostasis. Mechanisms of absorption, uptake and regulation . Acta Bioquimica Clinica Latinoamericana, 39(3), 301-314.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n3_p301_Perez [ ]
---------- CHICAGO ----------
Pérez, G., Vittori, D., Pregi, N., Garbossa, G., Nesse, A. "Iron homeostasis. Mechanisms of absorption, uptake and regulation " . Acta Bioquimica Clinica Latinoamericana 39, no. 3 (2005) : 301-314.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n3_p301_Perez [ ]
---------- MLA ----------
Pérez, G., Vittori, D., Pregi, N., Garbossa, G., Nesse, A. "Iron homeostasis. Mechanisms of absorption, uptake and regulation " . Acta Bioquimica Clinica Latinoamericana, vol. 39, no. 3, 2005, pp. 301-314.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n3_p301_Perez [ ]
---------- VANCOUVER ----------
Pérez, G., Vittori, D., Pregi, N., Garbossa, G., Nesse, A. Iron homeostasis. Mechanisms of absorption, uptake and regulation . Acta Bioquim. Clin. Latinoam. 2005;39(3):301-314.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n3_p301_Perez [ ]