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Abstract:

The aim of this work was to investigate the effect of anaesthesia with Enflurane or Isoflurane on the drug metabolizing system in mice under depletion or induction of cythocrome P-450 (CYP) provoked by allylisopropylacetamide (AIA) or Imidazol. To this end animals treated or not with AIA (350 mg/kg) or Imidazole (400 mg/kg) received a single dose of Enflurane or Isoflurane (1 mL/kg). In AIA treated mice, total CYP levels were strikingly diminished when the xenobiotic was administered either alone or plus the anaesthetics. In Imidazole treated mice, total CYP levels were first induced but they returned to control values by effect of the anaesthesia. CYP2E1 activity was strikingly increased in mice receiving the anaesthetics being higher in the group treated with Enflurane and Imidazole: this fact would indicate an increase in Enflurane metabolism. In AIA treated animals, anaesthesia produced no additional effect. Although, in those animals receiving Imidazole, Phase II enzymes activities were less reduced by the action of lsoflurane. A diminishment of Tryptophan pyrrolase activity was observed when the anaesthetics were administered to the Imidazole group, indicating a reduction in the heme regulatory pool. In conclusion, the effects of Enflurane and Isoflurane on drug metabolizing system were dependent on the CYP status and the anaesthetic assayed in spite of the fact that both compounds have a similar chemical structure.

Registro:

Documento: Artículo
Título:Enflurane and isoflurane anaesthetics. Their action on drug metabolizing enzyme system in mice under induction and depletion of cytochrome P450
Autor:Martínez, M.D.C.; Buzaleh, A.M.; Batlle, A.M.D.C.
Filiación:Centro de Investigaciones Sobre Porfirinas Y Porfirias (CIPYP), CONICET, Ciudad Universitaria, Pabellón II, Buenos Aires, Argentina
Viamonte 1881, C1056ABA Ciudad De Buenos Aires, Argentina
Palabras clave:Alilisopropilacetamide; Cytochrome P-450; Drug metabolizing enzyme system; Enflurane; Imidazole; Isoflurane; allylisopropylacetamide; anesthetic agent; cytochrome P450; cytochrome P450 2E1; drug metabolizing enzyme; enflurane; heme; imidazole; isoflurane; tryptophan 2,3 dioxygenase; xenobiotic agent; anesthesia; article; chemical structure; dose response; enzyme activity; metabolism; mouse; nonhuman; Animalia
Año:2005
Volumen:39
Número:1
Página de inicio:37
Página de fin:42
Título revista:Acta Bioquimica Clinica Latinoamericana
Título revista abreviado:Acta Bioquim. Clin. Latinoam.
ISSN:03252957
CODEN:ABCLD
CAS:allylisopropylacetamide, 299-78-5; cytochrome P450, 9035-51-2; enflurane, 13838-16-9; heme, 14875-96-8; imidazole, 1467-16-9, 288-32-4; isoflurane, 26675-46-7; tryptophan 2,3 dioxygenase, 9014-51-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n1_p37_Martinez

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Citas:

---------- APA ----------
Martínez, M.D.C., Buzaleh, A.M. & Batlle, A.M.D.C. (2005) . Enflurane and isoflurane anaesthetics. Their action on drug metabolizing enzyme system in mice under induction and depletion of cytochrome P450 . Acta Bioquimica Clinica Latinoamericana, 39(1), 37-42.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n1_p37_Martinez [ ]
---------- CHICAGO ----------
Martínez, M.D.C., Buzaleh, A.M., Batlle, A.M.D.C. "Enflurane and isoflurane anaesthetics. Their action on drug metabolizing enzyme system in mice under induction and depletion of cytochrome P450 " . Acta Bioquimica Clinica Latinoamericana 39, no. 1 (2005) : 37-42.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n1_p37_Martinez [ ]
---------- MLA ----------
Martínez, M.D.C., Buzaleh, A.M., Batlle, A.M.D.C. "Enflurane and isoflurane anaesthetics. Their action on drug metabolizing enzyme system in mice under induction and depletion of cytochrome P450 " . Acta Bioquimica Clinica Latinoamericana, vol. 39, no. 1, 2005, pp. 37-42.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n1_p37_Martinez [ ]
---------- VANCOUVER ----------
Martínez, M.D.C., Buzaleh, A.M., Batlle, A.M.D.C. Enflurane and isoflurane anaesthetics. Their action on drug metabolizing enzyme system in mice under induction and depletion of cytochrome P450 . Acta Bioquim. Clin. Latinoam. 2005;39(1):37-42.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n1_p37_Martinez [ ]