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Abstract:

Endothelial dysfunction has been defined as an imbalance between relaxing and contracting factors and has been implicated in the pathophysiology of several cardiovascular disorders, hypertension and diabetes. Plasmatic levels of endothelin-1, nitric oxide, von Willebrand factor, fibrinogen, glycated haemoglobin, glycaemia, Insulinaemia, lipid profile and blood pressure in 30 hypertensive and type II diabetic patients and 25 healthy subjects matched in age, sex, body mass index and smoking and dietary habits, were evaluated in order to study the relationship among these variables in the diabetic prothrombotic state. Endothelin-1, nitric oxide, von Willebrand factor and fibrinogen levels were higher in patients than in controls (p < 0.05). There was a significant positive correlation between nitric oxide and insulinaemia (p < 0.05) and between nitric oxide and von Willebrand factor (p < 0.05) in the group of patients. These data suggest that the prothrombotic state in these patients could be determined by the increased levels of endothelin-1, the high but less bioavailable nitric oxide values, the endothelial damage and inflammatory state reflected by high von Willebrand factor and fibrinogen levels associated with dyslipidemia and the insulin-resistance state.

Registro:

Documento: Artículo
Título:Endothelin-1, nitric oxide and von Willebrand factor in hypertensive type 2 diabetic patients
Autor:Ouviña, S.M.; Palmer, L.; Sassetti, B.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Hospital Churruca-Visca, Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Pab. II, 1428 Buenos Aires, Argentina
Palabras clave:Endothelial dysfunction; Endothelin-1; Nitric oxide; Type 2 diabetes; Von Willebrand factor; endothelin 1; fibrinogen; nitric oxide; von Willebrand factor; adult; aged; article; bioavailability; blood pressure monitoring; body mass; cardiovascular disease; clinical article; controlled study; correlation analysis; data analysis; diet; endothelium lesion; female; glucose blood level; glycation; hemoconcentration; hemoglobin determination; human; hypertension; inflammation; insulin resistance; insulinemia; intermethod comparison; lipid analysis; male; non insulin dependent diabetes mellitus; pathophysiology; sex difference; smoking; statistical significance; thrombosis
Año:2004
Volumen:38
Número:4
Página de inicio:471
Página de fin:476
Título revista:Acta Bioquimica Clinica Latinoamericana
Título revista abreviado:Acta Bioquim. Clin. Latinoam.
ISSN:03252957
CODEN:ABCLD
CAS:fibrinogen, 9001-32-5; nitric oxide, 10102-43-9; von Willebrand factor, 109319-16-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v38_n4_p471_Ouvina

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Citas:

---------- APA ----------
Ouviña, S.M., Palmer, L. & Sassetti, B. (2004) . Endothelin-1, nitric oxide and von Willebrand factor in hypertensive type 2 diabetic patients . Acta Bioquimica Clinica Latinoamericana, 38(4), 471-476.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v38_n4_p471_Ouvina [ ]
---------- CHICAGO ----------
Ouviña, S.M., Palmer, L., Sassetti, B. "Endothelin-1, nitric oxide and von Willebrand factor in hypertensive type 2 diabetic patients " . Acta Bioquimica Clinica Latinoamericana 38, no. 4 (2004) : 471-476.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v38_n4_p471_Ouvina [ ]
---------- MLA ----------
Ouviña, S.M., Palmer, L., Sassetti, B. "Endothelin-1, nitric oxide and von Willebrand factor in hypertensive type 2 diabetic patients " . Acta Bioquimica Clinica Latinoamericana, vol. 38, no. 4, 2004, pp. 471-476.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v38_n4_p471_Ouvina [ ]
---------- VANCOUVER ----------
Ouviña, S.M., Palmer, L., Sassetti, B. Endothelin-1, nitric oxide and von Willebrand factor in hypertensive type 2 diabetic patients . Acta Bioquim. Clin. Latinoam. 2004;38(4):471-476.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v38_n4_p471_Ouvina [ ]