Zanaro, N.L.; Cristina Romero, M.; Imventarza, O.; Sassetti, B. "Nitric oxide and enzymes in liver transplantation: Evolutive profiles " (2002) Acta Bioquimica Clinica Latinoamericana. 36(4):575-581
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Nitric oxide, a free radical and a potent vasodilator, also inhibits platelet adhesion and aggregation, reduces adhesion of leukocytes to the endothelium and suppresses proliferation of vascular smooth muscle cells. An inducible form of the nitric oxide synthase may generate large quantities of nitric oxide, and may be induced by the action of cytokines and lipopolysaccharides. Nitric oxide can be released from the hepatic vascular endothelium, platelets and Kupffer cells as a response to ischemia-reperfusion injury and circulatory shock. Levels of nitric oxide and some enzymes obtain-ed in serum samples before liver transplantation and every 48 h till day 15 were analysed in 20 patients in order to evaluate the evolution and the possible correlation between these parameters. Following a characteristic profile, aspartate aminotransferase and alanine aminotransferase levels changed from high at the beginning, to almost normal at the end of the study while, in most cases, nitric oxide kept a high level, which could be due to ischemic episodes that contributed to the expression of inducible nitric oxide synthase, as well as its activation by cytokines.


Documento: Artículo
Título:Nitric oxide and enzymes in liver transplantation: Evolutive profiles
Autor:Zanaro, N.L.; Cristina Romero, M.; Imventarza, O.; Sassetti, B.
Filiación:Depto. de Quím. Biol., Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Palabras clave:Liver transplantation; Nitric oxide; Nitric oxide synthase; alanine aminotransferase; aspartate aminotransferase; cytokine; enzyme; lipopolysaccharide; nitric acid; article; cell proliferation; enzyme blood level; evolution; human; ischemia; Kupffer cell; liver transplantation; muscle cell; nonhuman; protein expression; sampling; shock; smooth muscle fiber; thrombocyte; vascular endothelium; vasodilatation
Página de inicio:575
Página de fin:581
Título revista:Acta Bioquimica Clinica Latinoamericana
Título revista abreviado:Acta Bioquim. Clin. Latinoam.
CAS:alanine aminotransferase, 9000-86-6, 9014-30-6; aspartate aminotransferase, 9000-97-9; nitric acid, 7697-37-2


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---------- APA ----------
Zanaro, N.L., Cristina Romero, M., Imventarza, O. & Sassetti, B. (2002) . Nitric oxide and enzymes in liver transplantation: Evolutive profiles . Acta Bioquimica Clinica Latinoamericana, 36(4), 575-581.
Recuperado de [ ]
---------- CHICAGO ----------
Zanaro, N.L., Cristina Romero, M., Imventarza, O., Sassetti, B. "Nitric oxide and enzymes in liver transplantation: Evolutive profiles " . Acta Bioquimica Clinica Latinoamericana 36, no. 4 (2002) : 575-581.
Recuperado de [ ]
---------- MLA ----------
Zanaro, N.L., Cristina Romero, M., Imventarza, O., Sassetti, B. "Nitric oxide and enzymes in liver transplantation: Evolutive profiles " . Acta Bioquimica Clinica Latinoamericana, vol. 36, no. 4, 2002, pp. 575-581.
Recuperado de [ ]
---------- VANCOUVER ----------
Zanaro, N.L., Cristina Romero, M., Imventarza, O., Sassetti, B. Nitric oxide and enzymes in liver transplantation: Evolutive profiles . Acta Bioquim. Clin. Latinoam. 2002;36(4):575-581.
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