Artículo

Pérez, G.; Vittori, D.; Garbossa, G.; Nesse, A. "Aluminum toxicity in Erythropoiesis. Related mechanisms " (2002) Acta Bioquimica Clinica Latinoamericana. 36(1):41-50
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Abstract:

The mechanisms that could account for the aluminum-induced damage on erythropoiesis are thoroughly discussed. Similar affinity for transferrin binding to its specific receptor when carrying its physiological ligand iron or aluminum was found in assays employing erythroid cells. A competitive mechanism of cellular uptake between both metals seems to account for a compensatory response in order to take enough iron to fulfill the cellular normal metabolism. Nevertheless, hemoglobin synthesis is inhibited in the presence of aluminum. Based on these results, two main hypothesis are proposed: the interference of aluminum in the uptake and/or utilization of iron as well as the interaction of aluminum with cellular membrane components. The latter action could not only affect membrane protein structures but also their functions, such us the ligand binding to specific surface receptors. The reported mechanisms support the idea that both the disturbance of erythroid progenitor functions and/or the alterations of mature erythrocyte morphology might appear as a consequence of the presence of Al within the organism.

Registro:

Documento: Artículo
Título:Aluminum toxicity in Erythropoiesis. Related mechanisms
Autor:Pérez, G.; Vittori, D.; Garbossa, G.; Nesse, A.
Filiación:Departamento de Quimica Biologica, Fac. de Ciencias Exact. y Naturales, UBA Pabellón II, Piso 4, Ciudad Universitaria, (1428) Ciudad de Buenos Aires, Argentina
Palabras clave:Aluminum toxicity; Anemia; Band 3 protein; Erythrocyte morphology; Erythroid progenitor cells; Hemoglobin synthesis; Iron metabolism; K562 cells; Membrane proteins; Transferrin receptor; aluminum; cell surface receptor; hemoglobin; iron; ligand; membrane protein; transferrin; transferrin receptor; binding affinity; cell function; cell maturation; cell membrane; cell metabolism; cell transport; cell type; erythrocyte structure; erythroid cell; erythroid precursor cell; erythropoiesis; hemoglobin synthesis; human; iron metabolism; iron transport; ligand binding; molecular interaction; nonhuman; protein binding; protein function; protein structure; review
Año:2002
Volumen:36
Número:1
Página de inicio:41
Página de fin:50
Título revista:Acta Bioquimica Clinica Latinoamericana
Título revista abreviado:Acta Bioquim. Clin. Latinoam.
ISSN:03252957
CODEN:ABCLD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v36_n1_p41_Perez

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Citas:

---------- APA ----------
Pérez, G., Vittori, D., Garbossa, G. & Nesse, A. (2002) . Aluminum toxicity in Erythropoiesis. Related mechanisms . Acta Bioquimica Clinica Latinoamericana, 36(1), 41-50.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v36_n1_p41_Perez [ ]
---------- CHICAGO ----------
Pérez, G., Vittori, D., Garbossa, G., Nesse, A. "Aluminum toxicity in Erythropoiesis. Related mechanisms " . Acta Bioquimica Clinica Latinoamericana 36, no. 1 (2002) : 41-50.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v36_n1_p41_Perez [ ]
---------- MLA ----------
Pérez, G., Vittori, D., Garbossa, G., Nesse, A. "Aluminum toxicity in Erythropoiesis. Related mechanisms " . Acta Bioquimica Clinica Latinoamericana, vol. 36, no. 1, 2002, pp. 41-50.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v36_n1_p41_Perez [ ]
---------- VANCOUVER ----------
Pérez, G., Vittori, D., Garbossa, G., Nesse, A. Aluminum toxicity in Erythropoiesis. Related mechanisms . Acta Bioquim. Clin. Latinoam. 2002;36(1):41-50.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v36_n1_p41_Perez [ ]