Artículo
Pauza, N.L.; Pérez Cotti, M.J.; Godar, M.L.; Sopena, Y.; Ferramola De Sancovich, A.M.; Sancovich, H.A. "Cutaneous signs as parameter in teratogenicity by heavy metal intoxication " (2007) Revista Argentina de Dermatologia. 88(1):28-37
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Abstract:
Teratogenic effects of heavy metals (Cd2+- and Pb 2+-acetates and Cu2+-sulphate) were studied on chick embryos, after the administration as a single dose. Test materials were injected into the yolk on day 12 of incubation. Tested concentrations were (nmole/g egg): Cd2+ Dose 1(D1): 0.16 and Dose 2 (D2): 0.32; Pb2+: D1: 8.0 and D2: 16.0 and Cu2+: D1: 1.7 and D2: 3.3. Evaluations were performed after in ovo incubation for 12 and 60 hours. Embryonic mortality did not increase at the two dose levels of Cu2+ and Pb2+, while Cd2+ caused 30 and 86% of mortality, showing dose and time responses. Eggs treated with D2 of Cd2+ for 60 hs, significantly decreased the average of body mass embryo, when compared to the control group. Cd2+ administration was resposible for the most severe teratogenic signs compared to Cu2+ and Pb2+ treatments. It can be concluded that heavy metals are embryotoxic and teratogenics. We suggest that cutaneous and liver hemorrhages are the best signs to evaluate teratogenicity induced by Cd2+, Cu2+ and Pb2+.
Registro:
| Documento: | Artículo |
| Título: | Cutaneous signs as parameter in teratogenicity by heavy metal intoxication |
| Autor: | Pauza, N.L.; Pérez Cotti, M.J.; Godar, M.L.; Sopena, Y.; Ferramola De Sancovich, A.M.; Sancovich, H.A. |
| Filiación: | Universidad de Buenos Aires Carrera de Ciencias Biológicas Cátedra de Química Biológica CONICET Laboratorio de Porfirinas, Departamento de Química Biológica, Pabellón II, Ciudad Autónoma de Buenos Aires, Argentina |
| Palabras clave: | Chick embryos; Heavy metals; Teratogenic effects; Toxic effects; Yolk sac membrane; cadmium acetate; copper sulfate; lead acetate; animal experiment; animal model; article; body mass; chick embryo; controlled study; embryo; embryo mortality; heavy metal poisoning; liver hemorrhage; nonhuman; skin bleeding; skin manifestation; teratogenicity |
| Año: | 2007 |
| Volumen: | 88 |
| Número: | 1 |
| Página de inicio: | 28 |
| Página de fin: | 37 |
| Título revista: | Revista Argentina de Dermatologia |
| Título revista abreviado: | Rev. Argent. Dermatol. |
| ISSN: | 03252787 |
| CODEN: | RADEB |
| CAS: | cadmium acetate, 543-90-8; copper sulfate, 7758-98-7, 7758-99-8; lead acetate, 15347-57-6, 301-04-2 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252787_v88_n1_p28_Pauza |
Referencias:
- Adams, R.M., (1999) Ocupational skin disease, p. 792. , Tercera Edición. W B Saunders Co Philapelphia, London, Montevideo, Sidney, Tokyo
- Savaje, J.E., Trace minerals and avian reproduction (1968) Fed Proc, 27, pp. 927-931
- Bowen, H.J.M., (1976) Environmental Chemistry of the Elements, pp. 80-83. , Academic Press, New York. EEUU
- Vogiatz, A.K., Loumbourdis, N.S., Exposure of Rana ribunda to lead I. Study of lead accumulation in various tissues and hepatic a-aminolevulinic acid dehydratase activity (1999) J Appl Toxicol, 19 (1), pp. 25-29
- Jaffe, E.K., Martins, J., Li, J., Kervinen, J., Dunbrack Jr., R.L., The molecular mechanism of lead inhibition of human porphobilinogen synthase (2001) J Biol Chem, 276 (2), pp. 1531-1537
- Pauza, N.L., Sopena de Kracoff, Y., Ferramola de Sancovich, A.M., Sancovich, H.A., Ontogeny of 5-aminolevulinic dehydratase and porphobilinogen deaminase activities in the yolk sac membrane and liver of chick embryos (2002) Br Poult Sci, 43 (2), pp. 196-203
- Pauza, N.L., Sopena de Kracoff, Y.E., Ferramola de Sancovich, A.M., Sancovich, H.A., Estudios in vivo de la toxicidad del Pb2+,Cd2+ y Cu2+ y sus consecuencias en la biosíntesis del hemo (2004) Rev Argent Dermatol, 85, pp. 154-163
- Waalkes, M.P., Coogan, T.P., Barter, R.A., Toxicological principles of metal carcinogenesis with special emphasis on cadmium (1992) Crit Rev Toxicol, 22 (3-4), pp. 175-201
- Topalián, M.L., Castañé, P.M., Rovedani, M.G., Salivián, A., Principal component analysis of dissolved heavy metals in water of the Reconquista river (Buenos Aires, Argentina) (1999) Bull Environ Contam Toxicol, 63, pp. 484-490
- Loewy M, Kirs V, Carvajal G, Venturino y Pechen de D'Angelo AM. Groundwater contamination by azinphos methyl in the Northern Patagonic Region (Argentina). Sci Total Environ 1999; 225: 211-218; Goering, P.L., Lead-protein interactions as a basis for lead toxicity (1993) Neuro Toxicology, 14, pp. 45-60
- Da Fonseca, A., Nogueira Prista, L., (1987) Manual de Terapéutica Dermatológica y Cosmetológica, pp. 44-89. , Editorial Jims. Barcelona. España
- Mas A y Arola L Cadmium and lead toxicity effects on zinc, copper, nickel and iron distribution in the developing chick embryo. Comp Biochem Physiol C 1985; 80 (1): 185-188; Beattie, J.H., Owen, H.L., Wallace, S.M., Arthur, J.R., Kwun, I.S., Hawksworth, G.M., Wallace, H.M., Metallothionein overexpression and resistance to toxic stress (2005) Toxicol Lett, 157 (1), pp. 69-78
- Cao, J., Henry, P.R., Guo, R.H., Toth, J.P., Littell, R.C., Miles, R.D., Ammerman, C.B., Chemical characteristics and relative bioavailability of supplemental organic zinc sources for poultry and ruminants (2000) J Anim Sci, 78 (8), pp. 2039-2054
- Long, A., Wang, W.X., Assimilation and bioconcentration of Ag and Cd by the marine black bream after waterborne and dietary metal exposure (2005) Environ Toxicol Chem, 24 (3), pp. 709-716
- Lead, D.B.E., (1990) Heavy Metals in Soils, pp. 177-196. , Editorial Alloway BJ Blackie Academic. Glasgow. Wiley. New York
- Richards, M.P., Trace mineral metabolism in the avian embryo (1997) Poultry Science, 76, pp. 152-164
- Goering, P.L., Lead-protein interactions as a basis for lead toxicity (1988) Neuro Toxicol, 14, pp. 45-60
- Squitti, R., Pasqualetti, P., Cassetta, E., Dal Forno, G., Cesaretti, S., Pedace, F., Finazzi-Agro, A., Rossini, P.M., Elevation of serum copper levels discriminates Alzheimer's disease from vascular dementia (2003) Neurology, 60 (12), pp. 2013-2014
- Schumann, K., Classen, H.G., Dieter, H.H., Koning, J., Multhaup, G., Rukgauer, M., Summer, K.H., Biesalski, H.K., Hohenheim consensus workshop: Copper (2002) Eur J Clin Nutr, 56 (6), pp. 469-483
- Tapiero, H., Tew, K.D., Trace elements in human physiology and pathology: Zinc and metallothioneins (2003) Biomed Pharmacother, 57 (9), pp. 399-411
- Richards, M.P., Stock, M.K., Metcalfe, J., Effects of brief hypoxia on tissue trace element levels in the developing chick embryo (1991) Magnesium Trace Elem, 10, pp. 305-320
- Vallee, B.L., Ulmer, D.D., Biochemical effects of mercury, cadmium, and lead (1972) Ann Rev Biochem, 41, pp. 91-128
Citas:
---------- APA ----------
Pauza, N.L., Pérez Cotti, M.J., Godar, M.L., Sopena, Y., Ferramola De Sancovich, A.M. & Sancovich, H.A. (2007) . Cutaneous signs as parameter in teratogenicity by heavy metal intoxication . Revista Argentina de Dermatologia, 88(1), 28-37.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252787_v88_n1_p28_Pauza [ ]
---------- CHICAGO ----------
Pauza, N.L., Pérez Cotti, M.J., Godar, M.L., Sopena, Y., Ferramola De Sancovich, A.M., Sancovich, H.A. "Cutaneous signs as parameter in teratogenicity by heavy metal intoxication " . Revista Argentina de Dermatologia 88, no. 1 (2007) : 28-37.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252787_v88_n1_p28_Pauza [ ]
---------- MLA ----------
Pauza, N.L., Pérez Cotti, M.J., Godar, M.L., Sopena, Y., Ferramola De Sancovich, A.M., Sancovich, H.A. "Cutaneous signs as parameter in teratogenicity by heavy metal intoxication " . Revista Argentina de Dermatologia, vol. 88, no. 1, 2007, pp. 28-37.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252787_v88_n1_p28_Pauza [ ]
---------- VANCOUVER ----------
Pauza, N.L., Pérez Cotti, M.J., Godar, M.L., Sopena, Y., Ferramola De Sancovich, A.M., Sancovich, H.A. Cutaneous signs as parameter in teratogenicity by heavy metal intoxication . Rev. Argent. Dermatol. 2007;88(1):28-37.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252787_v88_n1_p28_Pauza [ ]
