Artículo
Guolo, M.; Stella, A.M.; Ferraris, J.; Ramirez, J.; De Enriquez Salamanca, R.; Batlle, A. "Urodecarboxilasa en sangre de pacientes hemodializados" (1996) Revista Argentina de Dermatologia. 77(3):155-162
Estamos trabajando para incorporar este artículo al repositorio
Consulte la política de Acceso Abierto del editor
Abstract:
in porphyria cutanea tarda (PCT), there is a fault in the activity of hepatic uroporphyrinogen decarboxylase (URO-D), and as a consequence, the concentration of highly carboxylated porphyrins is increased. However, the activity of blood URO-D is diminished only in hereditary PCT and is normal in the acquired form, The appearance of cutaneous blistering eruptions in hemodialysed patients has often been reported. Cutaneuous lesions are histoiogically and morphologically similar to those exhibited in PCT. The activity of URO-D was determined in red blood cells (RBC) from 12 hemodialysed patients, without cutaneous symptoms, one of them being carrier of hereditary PCT. Plasma porphyrins were also measured. The levels of plasma porphyrins were increased (0.084 ±1.0 ug/ml; uroporphyrins = 80%, coproporphyrins = 20%) in 30% of the non porphyric patients pior to hemodialysis (p < 0.001) compared with controls (normal value: 0.048 ±ug/ml; coproporphyrins 100%). Plasma porphyrins of the PCT patient at the begining of the treatment with S-adenosyl-L-methionine was: 1.71 ug/ml, uroporphyrins = 48%, heptaporphyrins = 41 %, hexaporphyrins = 7%, pentaporphyrins = 3% and coproporphyrins = 1 %. Six years after the end of treatment, lasma porphyrin vale was: 0.089 ug/ml; uroporphyrins = 80%, heptaporphyrins = 20%. Clinical remission was correlated with biochemical recovery. The activity of RBC URO-D was within the normal value (12.45 ±1.0 U/ml RBC) in all patients, except the true PCT case in whom the activity was reduced 50%. These results show that hemodialysis treatmentperse would not modify blood URO-D activity. Since plasma porphyrins levels were rised in a third of these patients, it is suggested that the observed abnormalities in heme metabolism may be due to altered hepatic function.
Registro:
| Documento: | Artículo |
| Título: | Urodecarboxilasa en sangre de pacientes hemodializados |
| Autor: | Guolo, M.; Stella, A.M.; Ferraris, J.; Ramirez, J.; De Enriquez Salamanca, R.; Batlle, A. |
| Filiación: | Centra de Investigaciones Sobre Porfirinas y Porfirias (CIPYP), Facultad de Ciencias Exactas y Naturales, UBA -Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET), Argentina Servicio de Hemodialisis Infantil Del Hospital Italiano Hospital 12 de Octubre, Universidad Complutense, Madrid, United States Becario de Perfeccionamiento Del CONICET, Argentina |
| Palabras clave: | Decarboxilase; Hemodialysed patients; Porphyria cutanea tarda; Pseudoporphyria; Uroporphyrinogen; carbocisteine; coproporphyrin; heme; porphyrin; uroporphyrin; uroporphyrinogen decarboxylase; adult; article; clinical article; controlled study; enzyme activity; female; hemodialysis; human; liver function; male; metabolism; porphyria cutanea tarda |
| Año: | 1996 |
| Volumen: | 77 |
| Número: | 3 |
| Página de inicio: | 155 |
| Página de fin: | 162 |
| Título revista: | Revista Argentina de Dermatologia |
| Título revista abreviado: | Rev. Argent. Dermatol. |
| ISSN: | 03252787 |
| CODEN: | RADEB |
| CAS: | carbocisteine, 638-23-3; coproporphyrin, 27121-71-7; heme, 14875-96-8; porphyrin, 24869-67-8; uroporphyrin, 18273-06-8, 26316-36-9, 553-18-4, 607-14-7; uroporphyrinogen decarboxylase, 9024-70-8 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252787_v77_n3_p155_Guolo |
Referencias:
- Baille, A., M. Del C. y Magnin, P. H.: Porfirias Humanas, en Porfirias y Porfirinas. Aspectos Cli'nicos y Bioquîmicos, Éd. Por Acta Bioquîmica Clînica Latinoamericana. Federacion Bioquîmica CKnica de la Provincia de Buenos Aires, Bs. As., Arg. Supl. N°2,1988, , pp 39-52
- Mascarö, J., M.; Lecha, M.; Herrera, C.; Muniesa S. y Smith, S.: Common and Uncommon Dermatological Manifestations of Porphyrias. A Study Based on Our Personal Experience. XVI International Congress of Dermatology, Symposium of Porphyrias, Tokyo, Ed. Por Garsi S.A., Madrid, 1982, , pp. 13-28
- Rocchi, E., Cassanelli, M.; Borghi A.; Paolillo, F.; Pradelli, M.; Pellizardi, S.; Vezzosi, A.; Gallo, E.; Baccarani Contri, M. y Ventura, E.: Liver Iron Overload and Desferrioxamine Treatment of Porphyria Cutaneatarda., , Dermatologica, 18227-31,1991
- Ippen, H., Alegemeinsymptome der Spalten Hautporphyrie (Porphyria Cutanea Tarda). Als Hinweise für Deren Behandlung Deutsche. Medizinesche, , Wochenschrift, 86:127-129,1961
- Batlle, A., M. Del C.; Stella, A.M.; Kaminisky, A. R.; Kaminisky, C. y Mariano, H. G.: Two Cases of Infantil Porphyria Cutanea Tarda: Successful Treatment with Oral S-adenosyl-L-methionine and Low-dose of Oral Chloroquine. Br. J., , Dermatol. 116:407-415,1987
- Jeronimo, A., E.; Magnin, P.; Enriquez de Salamanca, R.; Batlle, A. M. Del C.; Stella. A. M.; Melito, V. y Parera, V: Porfiria Cutânea Tarda y Hepatitis. Rev. Arg. Derm. 76, , 139 -147,1995
- Afonso, S.G., Chinarro Familiar, S.; Stella, A. M.; Batlle, A. M. Del C.; Lenczner, M. y Magnin P. H.: Uroporfirinögeno Decarboxilasa Eritrocitaria y Hepâtica en Porfiria Cutânea Tardia. Rev. Arg., , Derm. 66,12-24,1985
- Korting, G., W.: Über Porphyria-cutanea-tardaartige Langzeithamodialyse Patienten., , Dermatologica 150,58-61,1975
- Gilchrest, B., Rowe, J. W. y Mihm, M. C.: Bullous Demmatosis of Hemodialysis. Ann. Intern. Med. 83, , 480-4837 1975
- Trick, P.-F., M.B.; Masullo,A. S. y Grossman, M. E.: Porphyria Cutanea Tarda Associated with Chronic Renal Disease and Hemodialysis. Arch., , Dermatol. 116,191-195,1980
- Topi, G., C.; D'Alessandro Gandolfo, L.; Costanza, F. y de Cancarini, G. C.: Porphyria and Pseudoporphyria in Hemodialyzed Patients. Int. J., , Biochem. 12,963-967,1980
- Seubert, S., Seubert, A.; Wolfgang Rumpf, K. y Kiffe, H.: A Porphyria Cutanea Tarda - Like Distribution Pattern of Porphyrins in Plasma, Hemodialysate, Hemofil Träte, and Urine of Patients on Chronic Hemodialysis. J. Invest. Dermatol., , 85, 107-109,1985
- Guolo, M., Stella, A. M.; Melito, V; Parera, V. y Batlle, A. M. Del C.: Altered D-aminolevulinic Acid Metabolism Leading to Pseudoporphyria in Hemodialysed Patients. Int J. Biochem. & Cell Biol., , 28;311-317, 1996
- Stellaa, M., Melito, V; Parera, V. Cohan, R.; Hoyo, G.; Garcia Dîaz, R.; Pierini, A.; Ferraris, J. y Batlle, A. M. Del C.: Acerca de Dos Nuevos Casos de Porfiria Cutânea Tardia Infantil en Una Nina Con Leucemia y en un Nino Hemodializado en Tratamiento Con Sadenosil-L-metionina, Aspectos Bioquîmicos. Rev. Arg. Dermatol., , 69; 118-124,1988
- Schoua, A., E. M. y Batlle, A. M. Del C.: Indice de Porfirinas Plasmâticas: IPP. un Método Râpido Para la Caracterizacion de Las Porfirinas. Rev. Arg. Derm., , 68, 79-85,1987
- Rimington, C., Spectral-absorption Coefficients of Some Porphyrins in the Soret-band Region. Biochem J 75,620, , - 624,1960
- Seubert, A., Y Seubert,S. High-performance Liquid Chromatographie Analysis of Porphyrins and Their Isomers with Radical Compression Columns. Anal Biochem 124,303, , - 307,1982
- Mamet, R., Gafter, U.; Korzets, A. y Schoenfeld, N.: Decreased Uroporphyrinogen Decarboxylase Activity in Patients with End-stage Renal Disease Undergoing Hemodialysis. Nephron 70, , 202-206, 1995
- Senger, E., Bernd, A.; Kachel, H. G.; Schoeppe, W. y Holzmann, H.: Porphyria Cutanea Uraemica: An Obligate Systemic Disease in Chronic Kidney Insufficiency?, , Hautarzt 42,764-769,1991
- Fried, W., Hématologie Aspects of Uremia, in Clinical Dialysis, Ed. Por Allen, R.; Nissensori, D. E.; Gentile, R. Fine, 2da Ed., Norwalk, Connecticut/San Mateo, California, 1990, Pp, , 391 -408
- Smith, A., G. y Francis J. E.: Investigation of Rat Liver Uroporphyrinogen Decarboxylase Comparisons of Uroporphyrinogens i and 111 As Substrates and the Inhibition by Porphyrins. Biochem J., , 241,50 -61,1981
- Mukerji, S., K.; Pimstone, N. R. y Burns, M.: Dual Mechanism of Inhibition of Rat Liver Uroporphyrinogen Decarboxylase Activity by Ferrous Iron: Its Potential Role in the Genesis of Porphyria Cutanea Tarda. Gastroenterology 87, , 1248-1254, 1984
- Siersema, P., D.; Rademakers, L. H. P.; Cleton, M. 1.; Tenkate, F. J. W.; Debruijn, W. C; Marx, J. J. M. y Wilson, J. H. P. the Difference in Liver Pathology between Sporadic and Familial Forms of Porphyria Cutanea Tarda: the Role of Iron. J. Hepatol., , 23,259 267,1995
- Stella, A., M.; Rocchi, E.; Varela, L.; Parera, V.; Casalgrandi, G.; Magnin, P. H. y Batlle A. M. Del C.: Vitaminas Liposolubles y Carotenoides Naturales en Pacientes Porfiricos. Rev. Arg. Derm., , 76, 164-170,1995
- Guolo, M., Biscoglio, M.; Machalinski, C.; Stella, A. M.; Franco, A.; Pataro, L. y Batlle, A. M. Del C.: Isolation of An Inhibitor of D-aminolevulinic Acid Dehydratase Activity from Plasma of Hemodialysed Patients. en Proceedings of the Laboratory Medicine Llth IFCC European Congress of Clinical Chemistry, Helsinki, Finlandia, , pp 149,1995
- Ramsay, C., A. y Obreshkova, E.: Photosensitivity from Nalidixic Acid. Br J, , Dermatol. 91,523-528,1974
- Cantarovich, F., Galli, C; Benedetti, L.; Chena, C.; Castro, L.; Correa, C.; Ferez Loredo, J.; Femandez, J. C.; Locatellin, A. y Tizado, J.: High Dose Furesemide in Established Acute Renal Failure. Br Med, , J 24,449-450,1973
- Fontanellas, A., Herrero, J. A.; Moran, M. J.; Coronel, F.; Sepülveda, P.; Barrientos, A. y Enrîquez de Salamanca, R.: Efficiency of Three Different Hemodiaysis Membranes for Plasma Porphyrin Removal. Am J. Kidney, , Dis 25,30-33,1945
- Morân, M., J.; Fontanellas, A.; Santos, J. L. y Enrîquez de Salamanca, R. E.: Correlation between Levels of Free and Protein-bound Plasma Porphyrin and Urinary Porphyrins in Porphyria Cutanea Tarda. Int. J. Biochem. Cell Biol, , 27; 585588,1995
Citas:
---------- APA ----------
Guolo, M., Stella, A.M., Ferraris, J., Ramirez, J., De Enriquez Salamanca, R. & Batlle, A. (1996) . Urodecarboxilasa en sangre de pacientes hemodializados. Revista Argentina de Dermatologia, 77(3), 155-162.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252787_v77_n3_p155_Guolo [ ]
---------- CHICAGO ----------
Guolo, M., Stella, A.M., Ferraris, J., Ramirez, J., De Enriquez Salamanca, R., Batlle, A. "Urodecarboxilasa en sangre de pacientes hemodializados" . Revista Argentina de Dermatologia 77, no. 3 (1996) : 155-162.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252787_v77_n3_p155_Guolo [ ]
---------- MLA ----------
Guolo, M., Stella, A.M., Ferraris, J., Ramirez, J., De Enriquez Salamanca, R., Batlle, A. "Urodecarboxilasa en sangre de pacientes hemodializados" . Revista Argentina de Dermatologia, vol. 77, no. 3, 1996, pp. 155-162.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252787_v77_n3_p155_Guolo [ ]
---------- VANCOUVER ----------
Guolo, M., Stella, A.M., Ferraris, J., Ramirez, J., De Enriquez Salamanca, R., Batlle, A. Urodecarboxilasa en sangre de pacientes hemodializados. Rev. Argent. Dermatol. 1996;77(3):155-162.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252787_v77_n3_p155_Guolo [ ]
